GRP and MEP1A

Number of citations of the paper that reports this interaction (PMID 11278902)
30

Data Source:
HPRD (in vitro)

		GRP	MEP1A
Gene Name		gastrin-releasing peptide	meprin A, alpha (PABA peptide hydrolase)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Space Integral Component Of Plasma Membrane Meprin A Complex Extracellular Vesicular Exosome
	Molecular Function	Receptor Binding Neuropeptide Hormone Activity	Metalloendopeptidase Activity Protein Binding Zinc Ion Binding
	Biological Process	Signal Transduction Neuropeptide Signaling Pathway	Proteolysis Digestion
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding G alpha (q) signalling events Peptide hormone metabolism GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Incretin synthesis, secretion, and inactivation
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: DPP4 GRPR MEP1A MEP1B	19 interactors: AGT BDKRB1 CCK FN1 GCG GNRH1 GRP KNG1 LAMA1 LAMA5 MEP1B NPY NTS PLG POMC PTH SCT TAC1 VIP
Entrez ID		2922	4224
HPRD ID		08845	02666
Ensembl ID		ENSG00000134443	ENSG00000112818
Uniprot IDs		P07492	B7ZL91 Q16819
PDB IDs
Enriched GO Terms of Interacting Partners?		Digestion Bombesin Receptor Signaling Pathway Negative Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Extracellular Matrix Organization Proteolysis Regulation Of Cell-cell Adhesion Mediated By Integrin	Response To Stimulus Blood Circulation G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Renal Sodium Excretion Regulation Of Ion Homeostasis Behavior Regulation Of Blood Pressure Cell Surface Receptor Signaling Pathway Regulation Of Renal Sodium Excretion Regulation Of Appetite Neuropeptide Signaling Pathway Regulation Of Excretion Feeding Behavior Signal Transduction Regulation Of Corticosterone Secretion Cell-cell Signaling Response To External Stimulus Regulation Of Cell Migration Signaling Regulation Of Cell Motility Secretion Cell Communication Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Locomotion Regulation Of Cellular Component Movement Cellular Homeostasis Regulation Of Neurological System Process Cellular Metal Ion Homeostasis Positive Regulation Of Transport Inflammatory Response Positive Regulation Of CAMP Biosynthetic Process Response To Nutrient Levels Cellular Cation Homeostasis Positive Regulation Of CAMP Metabolic Process Cellular Ion Homeostasis Single-organism Behavior Platelet Degranulation Response To Extracellular Stimulus Metal Ion Homeostasis Regulation Of Blood Vessel Size Regulation Of Tube Size Secretion By Cell Chemical Homeostasis Cellular Response To Stimulus Blood Vessel Development Regulation Of Cellular Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process
Tagcloud ?		activators arsenite cations chaperones chemicals coordinate coupling cycling describing emphasized grp78 grps homeostatic hsp hsps integrative loading misfolding mobilizing modeled oxidants pertaining processing relates relating relationships thiol translation trigger	accumulating anthropometric borderline carriers disturbances exonuclease fertility fluorogenic genbank gg gt hirsutism homa homeostatic hormonal hyperandrogenemia id obese ovary overweight pcos polycystic prominent rs17468190 taqman triglyceride tt utr variants
Tagcloud (Difference) ?		activators arsenite cations chaperones chemicals coordinate coupling cycling describing emphasized grp78 grps hsp hsps integrative loading misfolding mobilizing modeled oxidants pertaining processing relates relating relationships thiol translation trigger	accumulating anthropometric borderline carriers disturbances exonuclease fertility fluorogenic genbank gg gt hirsutism homa hormonal hyperandrogenemia id obese ovary overweight pcos polycystic prominent rs17468190 taqman triglyceride tt utr variants
Tagcloud (Intersection) ?		homeostatic