GRM7 and TUBA3C

Number of citations of the paper that reports this interaction (PMID 11953448)
7

Data Source:
HPRD (in vitro, in vivo)

		GRM7	TUBA3C
Gene Name		glutamate receptor, metabotropic 7	tubulin, alpha 3c
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Cortex Integral Component Of Membrane Axon Dendrite Asymmetric Synapse Presynaptic Membrane Dendritic Shaft Receptor Complex Postsynaptic Membrane Presynaptic Active Zone	Nucleus Cytoplasm Microtubule
	Molecular Function	Group III Metabotropic Glutamate Receptor Activity Voltage-gated Calcium Channel Activity Calcium Channel Regulator Activity Calcium Ion Binding Glutamate Receptor Activity Adenylate Cyclase Inhibitor Activity Glutamate Binding PDZ Domain Binding Serine Binding	GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding
	Biological Process	Conditioned Taste Aversion Behavioral Fear Response Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G-protein Coupled Glutamate Receptor Signaling Pathway Synaptic Transmission Sensory Perception Of Sound Sensory Perception Of Smell Short-term Memory Negative Regulation Of Glutamate Secretion Transmission Of Nerve Impulse Adult Behavior Negative Regulation Of CAMP Biosynthetic Process Regulation Of Cyclase Activity Regulation Of Synaptic Transmission, Glutamatergic Calcium Ion Transmembrane Transport	Protein Folding Microtubule-based Process Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Protein Polymerization
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class C/3 (Metabotropic glutamate/pheromone receptors)	Transport of connexons to the plasma membrane Mitotic Prometaphase Organelle biogenesis and maintenance Axon guidance Hedgehog 'off' state Separation of Sister Chromatids Translocation of GLUT4 to the plasma membrane G2/M Transition L1CAM interactions Mitotic Anaphase Recycling pathway of L1 Recruitment of NuMA to mitotic centrosomes Formation of tubulin folding intermediates by CCT/TriC Intraflagellar transport M Phase Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Post-chaperonin tubulin folding pathway Gap junction trafficking and regulation MHC class II antigen presentation Recruitment of mitotic centrosome proteins and complexes Protein folding Gap junction assembly Gap junction trafficking Kinesins Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Assembly of the primary cilium Factors involved in megakaryocyte development and platelet production Cell Cycle, Mitotic Resolution of Sister Chromatid Cohesion Chaperonin-mediated protein folding Signaling by Hedgehog Centrosome maturation Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs		L-Glutamic Acid	Epothilone D Epothilone B
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) ( 23648065) Major depressive disorder (broad) ( 20038947) Orofacial clefts ( 22419666) Panic disorder ( 19165232) Personality dimensions ( 21368711) Visceral adipose tissue adjusted for BMI ( 22589738)	Fasting insulin-related traits (interaction with BMI) ( 22581228)
Protein-Protein Interactions		12 interactors: CALM1 CALM2 CALM3 FLNA GNAQ GRIPAP1 PICK1 TUBA1A TUBA1B TUBA3C TUBA4A TUBA8	11 interactors: DYNLL1 DYNLT1 FYN GRM7 MYC NMI PFDN5 PXN SIAH1 TUBG1 YWHAQ
Entrez ID		2917	7278
HPRD ID		04979	03958
Ensembl ID		ENSG00000196277
Uniprot IDs		B2R693 B9EGG9 Q14831 Q59G95	Q13748 Q1ZYQ1
PDB IDs		3MQ4
Enriched GO Terms of Interacting Partners?		Platelet Degranulation Platelet Activation Protein Polymerization Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Activation Of Phospholipase C Activity 'de Novo' Posttranslational Protein Folding Positive Regulation Of Phospholipase C Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity 'de Novo' Protein Folding Blood Coagulation Hemostasis Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Phospholipase Activity Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation Regulation Of Phospholipase Activity Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Lipase Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Glycogen Catabolic Process Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Cation Channel Activity Regulation Of Body Fluid Levels Polysaccharide Catabolic Process Positive Regulation Of Monooxygenase Activity Wound Healing Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Activation Of Adenylate Cyclase Activity Nitric Oxide Metabolic Process Cellular Protein Complex Assembly Exocytosis Cell Activation Regulation Of Protein Autophosphorylation Reactive Nitrogen Species Metabolic Process Rhodopsin Mediated Signaling Pathway Cellular Carbohydrate Catabolic Process Response To Wounding Positive Regulation Of Phosphatase Activity	Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Metabolic Process Regulation Of Cellular Component Organization Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Substantia Nigra Development Positive Regulation Of Signal Transduction Cell Cycle Multicellular Organismal Development Regulation Of Apoptotic Process Neural Nucleus Development Anatomical Structure Development Anatomical Structure Morphogenesis Positive Regulation Of Mitochondrion Organization Regulation Of Cell Death Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Regulation Of Organelle Organization Developmental Process Regulation Of Intracellular Signal Transduction Midbrain Development Apoptotic Process Programmed Cell Death System Development Regulation Of Mitochondrion Organization Regulation Of Cellular Localization Intracellular Signal Transduction Feeding Behavior Cell Cycle Process Fibroblast Apoptotic Process Cell Death Cell Morphogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Death Cytoskeleton Organization Cell Projection Organization G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cellular Metabolic Process Viral Process Learning Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Shape Response To Growth Factor
Tagcloud ?		adhd asparate biased cdi chi2 cpt deficit disequilibrium ga genotype gg grin2a grin2b hyperactivity inventory ionotropic korean metabotropic mglur7 omission preferential probands rs2284411 rs3792452 rs37952452 rs8049651 staic tdt trios
Tagcloud (Difference) ?		adhd asparate biased cdi chi2 cpt deficit disequilibrium ga genotype gg grin2a grin2b hyperactivity inventory ionotropic korean metabotropic mglur7 omission preferential probands rs2284411 rs3792452 rs37952452 rs8049651 staic tdt trios
Tagcloud (Intersection) ?