GRM7 and TUBA8

Number of citations of the paper that reports this interaction (PMID 11953448)
7

Data Source:
HPRD (in vitro, in vivo)

		GRM7	TUBA8
Gene Name		glutamate receptor, metabotropic 7	tubulin, alpha 8
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Cortex Integral Component Of Membrane Axon Dendrite Asymmetric Synapse Presynaptic Membrane Dendritic Shaft Receptor Complex Postsynaptic Membrane Presynaptic Active Zone	Cytoplasm Microtubule
	Molecular Function	Group III Metabotropic Glutamate Receptor Activity Voltage-gated Calcium Channel Activity Calcium Channel Regulator Activity Calcium Ion Binding Glutamate Receptor Activity Adenylate Cyclase Inhibitor Activity Glutamate Binding PDZ Domain Binding Serine Binding	GTPase Activity Structural Constituent Of Cytoskeleton GTP Binding
	Biological Process	Conditioned Taste Aversion Behavioral Fear Response Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G-protein Coupled Glutamate Receptor Signaling Pathway Synaptic Transmission Sensory Perception Of Sound Sensory Perception Of Smell Short-term Memory Negative Regulation Of Glutamate Secretion Transmission Of Nerve Impulse Adult Behavior Negative Regulation Of CAMP Biosynthetic Process Regulation Of Cyclase Activity Regulation Of Synaptic Transmission, Glutamatergic Calcium Ion Transmembrane Transport	Microtubule-based Process Protein Polymerization
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs		L-Glutamic Acid	Epothilone D Epothilone B
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) ( 23648065) Major depressive disorder (broad) ( 20038947) Orofacial clefts ( 22419666) Panic disorder ( 19165232) Personality dimensions ( 21368711) Visceral adipose tissue adjusted for BMI ( 22589738)
Protein-Protein Interactions		12 interactors: CALM1 CALM2 CALM3 FLNA GNAQ GRIPAP1 PICK1 TUBA1A TUBA1B TUBA3C TUBA4A TUBA8	5 interactors: GRM7 MYC PXN SIAH1 TCP1
Entrez ID		2917	51807
HPRD ID		04979	05763
Ensembl ID		ENSG00000196277	ENSG00000183785
Uniprot IDs		B2R693 B9EGG9 Q14831 Q59G95	Q9NY65
PDB IDs		3MQ4
Enriched GO Terms of Interacting Partners?		Platelet Degranulation Platelet Activation Protein Polymerization Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Activation Of Phospholipase C Activity 'de Novo' Posttranslational Protein Folding Positive Regulation Of Phospholipase C Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity 'de Novo' Protein Folding Blood Coagulation Hemostasis Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Phospholipase Activity Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation Regulation Of Phospholipase Activity Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Lipase Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Glycogen Catabolic Process Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Cation Channel Activity Regulation Of Body Fluid Levels Polysaccharide Catabolic Process Positive Regulation Of Monooxygenase Activity Wound Healing Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Activation Of Adenylate Cyclase Activity Nitric Oxide Metabolic Process Cellular Protein Complex Assembly Exocytosis Cell Activation Regulation Of Protein Autophosphorylation Reactive Nitrogen Species Metabolic Process Rhodopsin Mediated Signaling Pathway Cellular Carbohydrate Catabolic Process Response To Wounding Positive Regulation Of Phosphatase Activity	Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Translocation Of Peptides Or Proteins Into Host Cell Cytoplasm Transforming Growth Factor Beta Receptor Signaling Pathway Fibroblast Apoptotic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Branching Morphogenesis Of An Epithelial Tube Morphogenesis Of A Branching Epithelium Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Morphogenesis Of A Branching Structure Conditioned Taste Aversion Regulation Of Signaling Negative Regulation Of Monocyte Differentiation Negative Regulation Of Glutamate Secretion Positive Regulation Of Cell Proliferation Involved In Kidney Development Cellular Protein Complex Assembly Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Adenylate Cyclase-inhibiting G-protein Coupled Glutamate Receptor Signaling Pathway Regulation Of Macrophage Apoptotic Process Epithelial Tube Morphogenesis Regulation Of Cell Death Regulation Of Glutamate Secretion Tubulin Complex Assembly Regulation Of Monocyte Differentiation Signal Complex Assembly Short-term Memory Tube Morphogenesis Regulation Of Intracellular Signal Transduction G-protein Coupled Glutamate Receptor Signaling Pathway Regulation Of Telomere Maintenance Positive Regulation Of DNA Biosynthetic Process Morphogenesis Of An Epithelium Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Protein Destabilization Growth Hormone Receptor Signaling Pathway Oxygen Transport Cellular Response To Growth Hormone Stimulus Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Negative Regulation Of CAMP Biosynthetic Process Positive Regulation Of Programmed Cell Death Response To Growth Factor Focal Adhesion Assembly Regulation Of MAPK Cascade Positive Regulation Of Cell Death Negative Regulation Of CAMP Metabolic Process Cellular Macromolecular Complex Assembly Tissue Morphogenesis
Tagcloud ?		adhd asparate biased cdi chi2 cpt deficit disequilibrium ga genotype gg grin2a grin2b hyperactivity inventory ionotropic korean metabotropic mglur7 omission preferential probands rs2284411 rs3792452 rs37952452 rs8049651 staic tdt trios	abnormality acetyltransferase anatomical atypical autosomal autozygosity believed correct cytoskeletal doublecortin elongator generalized germline hypoplasia identities lis1 lissencephaly mapping microtubule neurodevelopmental neuron optic pmgoh polymicrogyria recessive recognizable tuba1a tubulin underscored
Tagcloud (Difference) ?		adhd asparate biased cdi chi2 cpt deficit disequilibrium ga genotype gg grin2a grin2b hyperactivity inventory ionotropic korean metabotropic mglur7 omission preferential probands rs2284411 rs3792452 rs37952452 rs8049651 staic tdt trios	abnormality acetyltransferase anatomical atypical autosomal autozygosity believed correct cytoskeletal doublecortin elongator generalized germline hypoplasia identities lis1 lissencephaly mapping microtubule neurodevelopmental neuron optic pmgoh polymicrogyria recessive recognizable tuba1a tubulin underscored
Tagcloud (Intersection) ?