GRM7 and GRIPAP1

Number of citations of the paper that reports this interaction (PMID 11891216)
25

Data Source:
HPRD (two hybrid, in vitro)

		GRM7	GRIPAP1
Gene Name		glutamate receptor, metabotropic 7	GRIP1 associated protein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Cortex Integral Component Of Membrane Axon Dendrite Asymmetric Synapse Presynaptic Membrane Dendritic Shaft Receptor Complex Postsynaptic Membrane Presynaptic Active Zone	Early Endosome Blood Microparticle
	Molecular Function	Group III Metabotropic Glutamate Receptor Activity Voltage-gated Calcium Channel Activity Calcium Channel Regulator Activity Calcium Ion Binding Glutamate Receptor Activity Adenylate Cyclase Inhibitor Activity Glutamate Binding PDZ Domain Binding Serine Binding	Molecular_function
	Biological Process	Conditioned Taste Aversion Behavioral Fear Response Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G-protein Coupled Glutamate Receptor Signaling Pathway Synaptic Transmission Sensory Perception Of Sound Sensory Perception Of Smell Short-term Memory Negative Regulation Of Glutamate Secretion Transmission Of Nerve Impulse Adult Behavior Negative Regulation Of CAMP Biosynthetic Process Regulation Of Cyclase Activity Regulation Of Synaptic Transmission, Glutamatergic Calcium Ion Transmembrane Transport	Biological_process
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs		L-Glutamic Acid
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) ( 23648065) Major depressive disorder (broad) ( 20038947) Orofacial clefts ( 22419666) Panic disorder ( 19165232) Personality dimensions ( 21368711) Visceral adipose tissue adjusted for BMI ( 22589738)
Protein-Protein Interactions		12 interactors: CALM1 CALM2 CALM3 FLNA GNAQ GRIPAP1 PICK1 TUBA1A TUBA1B TUBA3C TUBA4A TUBA8	12 interactors: ARL15 CASP3 CCNT1 GRIA1 GRIP1 GRM7 RAB4A SMAD2 SMURF1 SPP1 TCEA2 TES
Entrez ID		2917	56850
HPRD ID		04979	02325
Ensembl ID		ENSG00000196277	ENSG00000068400
Uniprot IDs		B2R693 B9EGG9 Q14831 Q59G95	Q4V328
PDB IDs		3MQ4
Enriched GO Terms of Interacting Partners?		Platelet Degranulation Platelet Activation Protein Polymerization Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Activation Of Phospholipase C Activity 'de Novo' Posttranslational Protein Folding Positive Regulation Of Phospholipase C Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity 'de Novo' Protein Folding Blood Coagulation Hemostasis Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Phospholipase Activity Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation Regulation Of Phospholipase Activity Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Lipase Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Glycogen Catabolic Process Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Cation Channel Activity Regulation Of Body Fluid Levels Polysaccharide Catabolic Process Positive Regulation Of Monooxygenase Activity Wound Healing Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Activation Of Adenylate Cyclase Activity Nitric Oxide Metabolic Process Cellular Protein Complex Assembly Exocytosis Cell Activation Regulation Of Protein Autophosphorylation Reactive Nitrogen Species Metabolic Process Rhodopsin Mediated Signaling Pathway Cellular Carbohydrate Catabolic Process Response To Wounding Positive Regulation Of Phosphatase Activity	Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To Stimulus Response To Transforming Growth Factor Beta Signal Transduction Cellular Response To Growth Factor Stimulus Response To Growth Factor Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Signaling Regulation Of Cellular Process Cell Communication Glutamate Receptor Signaling Pathway Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Stimulus Enzyme Linked Receptor Protein Signaling Pathway Receptor Metabolic Process Regulation Of BMP Signaling Pathway Cell-cell Signaling DNA-templated Transcription, Elongation Extracellular Matrix Disassembly Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Intracellular Signal Transduction Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Zygotic Specification Of Dorsal/ventral Axis Protein Localization Memory Cell Surface Receptor Signaling Pathway Sensory Perception Of Sound Synaptic Transmission Positive Regulation Of Mesoderm Development Conditioned Taste Aversion Primary MiRNA Processing Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Ubiquitin-dependent SMAD Protein Catabolic Process Regulation Of Nodal Signaling Pathway Negative Regulation Of Collateral Sprouting Negative Regulation Of Glutamate Secretion Common-partner SMAD Protein Phosphorylation Glial Cell Apoptotic Process Sensory Perception Of Mechanical Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Activin Receptor Signaling Pathway Regulation Of Apoptotic DNA Fragmentation
Tagcloud ?		adhd asparate biased cdi chi2 cpt deficit disequilibrium ga genotype gg grin2a grin2b hyperactivity inventory ionotropic korean metabotropic mglur7 omission preferential probands rs2284411 rs3792452 rs37952452 rs8049651 staic tdt trios
Tagcloud (Difference) ?		adhd asparate biased cdi chi2 cpt deficit disequilibrium ga genotype gg grin2a grin2b hyperactivity inventory ionotropic korean metabotropic mglur7 omission preferential probands rs2284411 rs3792452 rs37952452 rs8049651 staic tdt trios
Tagcloud (Intersection) ?