GRM7 and GNAQ

Number of citations of the paper that reports this interaction (PMID 10550060)
33

Data Source:
HPRD (in vitro)

		GRM7	GNAQ
Gene Name		glutamate receptor, metabotropic 7	guanine nucleotide binding protein (G protein), q polypeptide
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Cortex Integral Component Of Membrane Axon Dendrite Asymmetric Synapse Presynaptic Membrane Dendritic Shaft Receptor Complex Postsynaptic Membrane Presynaptic Active Zone	Cytoplasm Lysosomal Membrane Heterotrimeric G-protein Complex Plasma Membrane Nuclear Membrane Extracellular Vesicular Exosome
	Molecular Function	Group III Metabotropic Glutamate Receptor Activity Voltage-gated Calcium Channel Activity Calcium Channel Regulator Activity Calcium Ion Binding Glutamate Receptor Activity Adenylate Cyclase Inhibitor Activity Glutamate Binding PDZ Domain Binding Serine Binding	GTPase Activity Signal Transducer Activity GTPase Activator Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Type 2A Serotonin Receptor Binding Metal Ion Binding
	Biological Process	Conditioned Taste Aversion Behavioral Fear Response Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G-protein Coupled Glutamate Receptor Signaling Pathway Synaptic Transmission Sensory Perception Of Sound Sensory Perception Of Smell Short-term Memory Negative Regulation Of Glutamate Secretion Transmission Of Nerve Impulse Adult Behavior Negative Regulation Of CAMP Biosynthetic Process Regulation Of Cyclase Activity Regulation Of Synaptic Transmission, Glutamatergic Calcium Ion Transmembrane Transport	Skeletal System Development Action Potential Negative Regulation Of Protein Kinase Activity Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Glutamate Receptor Signaling Pathway Heart Development Blood Coagulation Post-embryonic Development Neuron Remodeling Forebrain Neuron Development Platelet Activation Regulation Of Catenin Import Into Nucleus Maternal Behavior Embryonic Digit Morphogenesis Positive Regulation Of GTPase Activity Regulation Of Melanocyte Differentiation Developmental Pigmentation Protein Stabilization Phospholipase C-activating Dopamine Receptor Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class C/3 (Metabotropic glutamate/pheromone receptors)	G alpha (q) signalling events Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Signaling by GPCR ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism Regulation of insulin secretion Signal amplification Thrombin signalling through proteinase activated receptors (PARs) G alpha (q) signalling events GPCR downstream signaling Acetylcholine regulates insulin secretion Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor Platelet activation, signaling and aggregation Free fatty acids regulate insulin secretion
Drugs		L-Glutamic Acid
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) ( 23648065) Major depressive disorder (broad) ( 20038947) Orofacial clefts ( 22419666) Panic disorder ( 19165232) Personality dimensions ( 21368711) Visceral adipose tissue adjusted for BMI ( 22589738)
Protein-Protein Interactions		12 interactors: CALM1 CALM2 CALM3 FLNA GNAQ GRIPAP1 PICK1 TUBA1A TUBA1B TUBA3C TUBA4A TUBA8	48 interactors: ADHFE1 ADRA1B ADRBK1 AIP AKAP13 BDKRB1 BTK CCR5 CHRM3 CRHR1 CYTH1 CYTH2 FFAR1 FFAR2 GALR2 GRM2 GRM4 GRM7 HTR2A HTR2B HTR2C HTR6 KDR LUM MRGPRX1 NT5C3A PIK3CA PLCB1 PLCB2 PPT1 PTGIR RGS13 RGS16 RGS18 RGS2 RGS4 RGS5 RGS7 RIC8A RIC8B S1PR2 S1PR3 SLC9A3R1 TBXA2R TSHR TTC1 TUB VIPR1
Entrez ID		2917	2776
HPRD ID		04979	02998
Ensembl ID		ENSG00000196277
Uniprot IDs		B2R693 B9EGG9 Q14831 Q59G95	P50148
PDB IDs		3MQ4
Enriched GO Terms of Interacting Partners?		Platelet Degranulation Platelet Activation Protein Polymerization Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Activation Of Phospholipase C Activity 'de Novo' Posttranslational Protein Folding Positive Regulation Of Phospholipase C Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity 'de Novo' Protein Folding Blood Coagulation Hemostasis Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Phospholipase Activity Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation Regulation Of Phospholipase Activity Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Lipase Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Glycogen Catabolic Process Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Cation Channel Activity Regulation Of Body Fluid Levels Polysaccharide Catabolic Process Positive Regulation Of Monooxygenase Activity Wound Healing Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Activation Of Adenylate Cyclase Activity Nitric Oxide Metabolic Process Cellular Protein Complex Assembly Exocytosis Cell Activation Regulation Of Protein Autophosphorylation Reactive Nitrogen Species Metabolic Process Rhodopsin Mediated Signaling Pathway Cellular Carbohydrate Catabolic Process Response To Wounding Positive Regulation Of Phosphatase Activity	G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Catalytic Activity Cell-cell Signaling Signal Transduction Signaling Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Signaling Cell Communication Positive Regulation Of Hydrolase Activity Positive Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of GTPase Activity Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Stimulus Regulation Of Signal Transduction Single-organism Behavior Regulation Of Cellular Process Chemical Homeostasis Behavior Learning Or Memory Cytosolic Calcium Ion Homeostasis Cognition Calcium Ion Homeostasis Regulation Of Metabolic Process Ion Homeostasis Cellular Ion Homeostasis Synaptic Transmission Regulation Of Secretion Neurological System Process Cellular Chemical Homeostasis Cellular Calcium Ion Homeostasis Learning Cellular Cation Homeostasis Serotonin Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Phospholipase Activity Metal Ion Homeostasis Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol Biosynthetic Process Homeostatic Process Negative Regulation Of Signaling
Tagcloud ?		adhd asparate biased cdi chi2 cpt deficit disequilibrium ga genotype gg grin2a grin2b hyperactivity inventory ionotropic korean metabotropic mglur7 omission preferential probands rs2284411 rs3792452 rs37952452 rs8049651 staic tdt trios	adaptor contributing driving extensively flies gna11 gpcrs gq guan hippo lats1 malignancy mammals melanoma mob1 mst1 ocular oncogenes oncotarget opportunity persistently phosphorylates represents sav1 taz team uveal ww45 yap
Tagcloud (Difference) ?		adhd asparate biased cdi chi2 cpt deficit disequilibrium ga genotype gg grin2a grin2b hyperactivity inventory ionotropic korean metabotropic mglur7 omission preferential probands rs2284411 rs3792452 rs37952452 rs8049651 staic tdt trios	adaptor contributing driving extensively flies gna11 gpcrs gq guan hippo lats1 malignancy mammals melanoma mob1 mst1 ocular oncogenes oncotarget opportunity persistently phosphorylates represents sav1 taz team uveal ww45 yap
Tagcloud (Intersection) ?