GNAI1 and S1PR1

Number of citations of the paper that reports this interaction (PMID 8626678)
27

Data Source:
BioGRID (affinity chromatography technology, pull down, two hybrid)
HPRD (in vitro, two hybrid, in vivo)

		GNAI1	S1PR1
Gene Name		guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	sphingosine-1-phosphate receptor 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Lysosomal Membrane Centrosome Heterotrimeric G-protein Complex Plasma Membrane Midbody Extracellular Vesicular Exosome	Endosome Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Intrinsic Component Of Plasma Membrane Membrane Raft
	Molecular Function	GTPase Activity Signal Transducer Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding G-protein Coupled Serotonin Receptor Binding Metal Ion Binding	G-protein Coupled Receptor Binding G-protein Coupled Receptor Activity Sphingosine-1-phosphate Receptor Activity Sphingolipid Binding
	Biological Process	Cell Cycle G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Blood Coagulation Platelet Activation Response To Peptide Hormone Cell Division	Angiogenesis Blood Vessel Maturation Cardiac Muscle Tissue Growth Involved In Heart Morphogenesis Sphingosine-1-phosphate Signaling Pathway Chemotaxis Cell Adhesion G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Brain Development Cell Migration Transmission Of Nerve Impulse Lamellipodium Assembly Regulation Of Cell Adhesion Neuron Differentiation Positive Regulation Of Cell Migration Regulation Of Bone Mineralization Actin Cytoskeleton Reorganization Positive Regulation Of Ras GTPase Activity Regulation Of Bone Resorption Endothelial Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Positive Chemotaxis Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Negative Regulation Of Stress Fiber Assembly Heart Trabecula Morphogenesis T Cell Migration
Pathways		Signaling by GPCR Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Signal amplification G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 GABA B receptor activation Adenylate cyclase inhibitory pathway GABA receptor activation PLC beta mediated events Opioid Signalling Regulation of insulin secretion G-protein mediated events Adrenaline,noradrenaline inhibits insulin secretion Inhibition of adenylate cyclase pathway Adenylate cyclase inhibitory pathway GPCR downstream signaling G-protein activation Platelet activation, signaling and aggregation Transmission across Chemical Synapses	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Lysosphingolipid and LPA receptors
Drugs
Diseases
GWAS
Protein-Protein Interactions		57 interactors: ADCY5 ADRA2A CCR5 CD47 CNR1 CRHR1 CXCR4 DRD3 EPOR ESR1 FFAR1 GNAO1 GNB2 GNB4 GPR1 GPR143 GPSM1 GPSM2 GPSM3 HRH4 HTR2A IGF1R KLHL3 MTNR1A MTNR1B NGB NUCB1 NUMA1 OPRD1 OPRM1 PDE6D PTPRU RANGAP1 RASD1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS20 RGS4 RGS7 RIC8A S1PR1 S1PR2 S1PR3 S1PR4 S1PR5 SSTR2 SSTR3 STRN THAP7 TSHR VIPR1 WASF1	8 interactors: AKT1 CAV1 CMSS1 GNAI1 GNAI3 HTR1A HTR1D PDGFRB
Entrez ID		2770	1901
HPRD ID		00756	03578
Ensembl ID		ENSG00000127955	ENSG00000170989
Uniprot IDs		P63096	P21453
PDB IDs		1KJY 1Y3A 2G83 2GTP 2IK8 2OM2 2PZ3 2XNS 3ONW 3QE0 3QI2 3UMR 3UMS 4G5Q	3V2W 3V2Y
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Surface Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Signal Transduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Signaling Cell Communication Regulation Of Catalytic Activity Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Cellular Response To Stimulus Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Response To Stimulus Regulation Of Signaling Positive Regulation Of Hydrolase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Sphingosine-1-phosphate Signaling Pathway Regulation Of Cellular Process Chemical Homeostasis Cell-cell Signaling Cytosolic Calcium Ion Homeostasis Positive Regulation Of GTPase Activity Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Synaptic Transmission Negative Regulation Of Signaling Behavior Cellular Metal Ion Homeostasis Neuropeptide Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Cellular Cation Homeostasis Ion Homeostasis Cellular Ion Homeostasis Homeostatic Process Metal Ion Homeostasis Negative Regulation Of Signal Transduction Cellular Chemical Homeostasis Locomotory Behavior Response To Ammonium Ion Negative Regulation Of Ion Transport Response To Cocaine Regulation Of Cell Proliferation Neurological System Process	Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Vasoconstriction G-protein Coupled Receptor Signaling Pathway Wound Healing Response To Wounding Cell Surface Receptor Signaling Pathway Regulation Of Blood Vessel Size Regulation Of Tube Size Blood Coagulation Hemostasis Serotonin Receptor Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Body Fluid Levels Regulation Of Ion Transport Regulation Of Behavior Platelet Activation Positive Regulation Of Ion Transport Vesicle Organization Signal Transduction Nitric Oxide Metabolic Process Positive Regulation Of Vasoconstriction Response To Hyperoxia Reactive Nitrogen Species Metabolic Process Response To Fluid Shear Stress Signaling Regulation Of Nitric-oxide Synthase Activity Cell Communication Membrane Organization Response To Stress Regulation Of Lipid Metabolic Process Blood Circulation Response To Hormone Negative Regulation Of Ion Transmembrane Transport Vesicle Fusion Negative Regulation Of Transmembrane Transport Regulation Of Vasoconstriction Regulation Of Nitric Oxide Biosynthetic Process Cellular Response To Stimulus Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Ion Transmembrane Transport T Cell Costimulation Regulation Of Oxidoreductase Activity Organelle Fusion Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Fatty Acid Metabolic Process Regulation Of Endothelial Cell Proliferation Positive Regulation Of Reactive Oxygen Species Metabolic Process
Tagcloud ?		alkenes azotic constructions gnao1 heterocycle hm hms htr1b htr2a htr2b htr4 htr6 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkcd prkce prkcg prkd1 propertied pubchem rock2 rps6ka1 rps6ka3 tlr8 tradition	148a accordingly adjacent carcinoma downregulated downregulation hepatocellular hepg2 inhibitory interfering invasion malignancies markedly microrna mimics mir negatively never notably numerous phosphate restoration reversed sipr1 sphingosine suppressor transfection upregulation whose
Tagcloud (Difference) ?		alkenes azotic constructions gnao1 heterocycle hm hms htr1b htr2a htr2b htr4 htr6 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkcd prkce prkcg prkd1 propertied pubchem rock2 rps6ka1 rps6ka3 tlr8 tradition	148a accordingly adjacent carcinoma downregulated downregulation hepatocellular hepg2 inhibitory interfering invasion malignancies markedly microrna mimics mir negatively never notably numerous phosphate restoration reversed sipr1 sphingosine suppressor transfection upregulation whose
Tagcloud (Intersection) ?