GNAI1 and RGS7

Number of citations of the paper that reports this interaction (PMID 9572280)
8

Data Source:
HPRD (in vitro)

		GNAI1	RGS7
Gene Name		guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	regulator of G-protein signaling 7
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Lysosomal Membrane Centrosome Heterotrimeric G-protein Complex Plasma Membrane Midbody Extracellular Vesicular Exosome	Nucleus Cytoplasm Cytosol Heterotrimeric G-protein Complex Plasma Membrane Dendrite Terminus
	Molecular Function	GTPase Activity Signal Transducer Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding G-protein Coupled Serotonin Receptor Binding Metal Ion Binding	Signal Transducer Activity GTPase Activator Activity G-protein Beta-subunit Binding
	Biological Process	Cell Cycle G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Blood Coagulation Platelet Activation Response To Peptide Hormone Cell Division	G-protein Coupled Receptor Signaling Pathway Intracellular Signal Transduction Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of GTPase Activity
Pathways		Signaling by GPCR Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Signal amplification G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 GABA B receptor activation Adenylate cyclase inhibitory pathway GABA receptor activation PLC beta mediated events Opioid Signalling Regulation of insulin secretion G-protein mediated events Adrenaline,noradrenaline inhibits insulin secretion Inhibition of adenylate cyclase pathway Adenylate cyclase inhibitory pathway GPCR downstream signaling G-protein activation Platelet activation, signaling and aggregation Transmission across Chemical Synapses	Signaling by GPCR GPCR downstream signaling G alpha (i) signalling events
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		57 interactors: ADCY5 ADRA2A CCR5 CD47 CNR1 CRHR1 CXCR4 DRD3 EPOR ESR1 FFAR1 GNAO1 GNB2 GNB4 GPR1 GPR143 GPSM1 GPSM2 GPSM3 HRH4 HTR2A IGF1R KLHL3 MTNR1A MTNR1B NGB NUCB1 NUMA1 OPRD1 OPRM1 PDE6D PTPRU RANGAP1 RASD1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS20 RGS4 RGS7 RIC8A S1PR1 S1PR2 S1PR3 S1PR4 S1PR5 SSTR2 SSTR3 STRN THAP7 TSHR VIPR1 WASF1	12 interactors: GNAI1 GNAI3 GNAO1 GNAQ GNAZ GNB5 MSX1 PKD1 PRKCA SNAPIN YWHAB YWHAQ
Entrez ID		2770	6000
HPRD ID		00756	03948
Ensembl ID		ENSG00000127955	ENSG00000182901
Uniprot IDs		P63096	P49802
PDB IDs		1KJY 1Y3A 2G83 2GTP 2IK8 2OM2 2PZ3 2XNS 3ONW 3QE0 3QI2 3UMR 3UMS 4G5Q	2A72 2D9J
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Surface Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Signal Transduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Signaling Cell Communication Regulation Of Catalytic Activity Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Cellular Response To Stimulus Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Response To Stimulus Regulation Of Signaling Positive Regulation Of Hydrolase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Sphingosine-1-phosphate Signaling Pathway Regulation Of Cellular Process Chemical Homeostasis Cell-cell Signaling Cytosolic Calcium Ion Homeostasis Positive Regulation Of GTPase Activity Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Synaptic Transmission Negative Regulation Of Signaling Behavior Cellular Metal Ion Homeostasis Neuropeptide Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Cellular Cation Homeostasis Ion Homeostasis Cellular Ion Homeostasis Homeostatic Process Metal Ion Homeostasis Negative Regulation Of Signal Transduction Cellular Chemical Homeostasis Locomotory Behavior Response To Ammonium Ion Negative Regulation Of Ion Transport Response To Cocaine Regulation Of Cell Proliferation Neurological System Process	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Signaling Cell Communication Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Signal Transduction Negative Regulation Of Transport Regulation Of Intracellular Transport Membrane Organization Platelet Activation Vesicle Fusion Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of Cellular Localization Organelle Fusion Cellular Response To Stimulus Regulation Of Establishment Of Protein Localization Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Protein Localization Membrane Fusion Positive Regulation Of Organelle Organization Nervous System Development Positive Regulation Of Blood Vessel Endothelial Cell Migration Blood Coagulation Hemostasis Negative Regulation Of Adenylate Cyclase Activity Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Negative Regulation Of Lyase Activity Response To Stimulus Cytoplasmic Sequestering Of Protein Central Nervous System Development Regulation Of Rhodopsin Mediated Signaling Pathway Detection Of Abiotic Stimulus Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of CAMP Biosynthetic Process Intrinsic Apoptotic Signaling Pathway Rhodopsin Mediated Signaling Pathway Negative Regulation Of CAMP Metabolic Process Cartilage Development Positive Regulation Of Apoptotic Signaling Pathway Skeletal System Development Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Dopamine Receptor Signaling Pathway Vesicle Organization Regulation Of Body Fluid Levels Synaptic Transmission Wound Healing Negative Regulation Of Nucleotide Metabolic Process Negative Regulation Of Calcium Ion Transport Regulation Of Protein Transport
Tagcloud ?		alkenes azotic constructions gnao1 heterocycle hm hms htr1b htr2a htr2b htr4 htr6 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkcd prkce prkcg prkd1 propertied pubchem rock2 rps6ka1 rps6ka3 tlr8 tradition	2a ag490 attenuated cortex corticosterone dependently desensitization frontal hormone hypothalamic increases jak mediating necessary nucleus olanzapine oxytocin paraventricular phospholipase prevented rat reductions regulator release reverse serotonin stat stimulated understand
Tagcloud (Difference) ?		alkenes azotic constructions gnao1 heterocycle hm hms htr1b htr2a htr2b htr4 htr6 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkcd prkce prkcg prkd1 propertied pubchem rock2 rps6ka1 rps6ka3 tlr8 tradition	2a ag490 attenuated cortex corticosterone dependently desensitization frontal hormone hypothalamic increases jak mediating necessary nucleus olanzapine oxytocin paraventricular phospholipase prevented rat reductions regulator release reverse serotonin stat stimulated understand
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