GNAI1 and ADCY5

Number of citations of the paper that reports this interaction (PMID 9748257)
17

Data Source:
BioGRID (biochemical)
HPRD (in vitro)

		GNAI1	ADCY5
Gene Name		guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	adenylate cyclase 5
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Lysosomal Membrane Centrosome Heterotrimeric G-protein Complex Plasma Membrane Midbody Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Membrane Primary Cilium
	Molecular Function	GTPase Activity Signal Transducer Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding G-protein Coupled Serotonin Receptor Binding Metal Ion Binding	Adenylate Cyclase Activity ATP Binding Adenylate Cyclase Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Cell Cycle G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Blood Coagulation Platelet Activation Response To Peptide Hormone Cell Division	Adenosine Receptor Signaling Pathway Renal Water Homeostasis Energy Reserve Metabolic Process CAMP Biosynthetic Process Water Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Activation Of Phospholipase C Activity Synaptic Transmission Locomotory Behavior Fibroblast Growth Factor Receptor Signaling Pathway Activation Of Protein Kinase A Activity Intracellular Signal Transduction Small Molecule Metabolic Process Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Neuromuscular Process Controlling Balance Transmembrane Transport Cellular Response To Glucagon Stimulus
Pathways		Signaling by GPCR Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Signal amplification G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 GABA B receptor activation Adenylate cyclase inhibitory pathway GABA receptor activation PLC beta mediated events Opioid Signalling Regulation of insulin secretion G-protein mediated events Adrenaline,noradrenaline inhibits insulin secretion Inhibition of adenylate cyclase pathway Adenylate cyclase inhibitory pathway GPCR downstream signaling G-protein activation Platelet activation, signaling and aggregation Transmission across Chemical Synapses	Signaling by GPCR Ca-dependent events CaM pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Hedgehog 'off' state Phospholipase C-mediated cascade Integration of energy metabolism Signaling by FGFR in disease Activation of GABAB receptors G alpha (s) signalling events Signaling by EGFRvIII in Cancer Adenylate cyclase activating pathway PLCG1 events in ERBB2 signaling DAP12 signaling G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Glucagon signaling in metabolic regulation Signaling by PDGF Calmodulin induced events DAP12 interactions PKA-mediated phosphorylation of CREB Opioid Signalling PKA activation Aquaporin-mediated transport EGFR interacts with phospholipase C-gamma Adrenaline,noradrenaline inhibits insulin secretion Signaling by ERBB2 Signaling by EGFR PKA-mediated phosphorylation of CREB GPCR downstream signaling Calmodulin induced events Downstream signal transduction Signaling by EGFR in Cancer PKA activation Transmission across Chemical Synapses DAG and IP3 signaling CaM pathway Downstream signaling of activated FGFR Innate Immune System GABA B receptor activation GABA receptor activation Adenylate cyclase inhibitory pathway PKA activation in glucagon signalling Signalling by NGF PLC beta mediated events Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion Signaling by Ligand-Responsive EGFR Variants in Cancer G-protein mediated events NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR Inhibition of adenylate cyclase pathway Adenylate cyclase inhibitory pathway Signaling by Hedgehog PLC-gamma1 signalling
Drugs
Diseases
GWAS			Birth weight ( 23202124 20372150) Fasting glucose-related traits ( 20081858) Fasting glucose-related traits (interaction with BMI) ( 22581228) Obesity-related traits ( 23251661) Two-hour glucose challenge ( 20081857) Type 2 diabetes ( 22693455)
Protein-Protein Interactions		57 interactors: ADCY5 ADRA2A CCR5 CD47 CNR1 CRHR1 CXCR4 DRD3 EPOR ESR1 FFAR1 GNAO1 GNB2 GNB4 GPR1 GPR143 GPSM1 GPSM2 GPSM3 HRH4 HTR2A IGF1R KLHL3 MTNR1A MTNR1B NGB NUCB1 NUMA1 OPRD1 OPRM1 PDE6D PTPRU RANGAP1 RASD1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS20 RGS4 RGS7 RIC8A S1PR1 S1PR2 S1PR3 S1PR4 S1PR5 SSTR2 SSTR3 STRN THAP7 TSHR VIPR1 WASF1	7 interactors: ADCY2 GNAI1 GNAS PRKACA PRKCA PRKCZ RGS2
Entrez ID		2770	111
HPRD ID		00756	08973
Ensembl ID		ENSG00000127955	ENSG00000173175
Uniprot IDs		P63096	B3KWA8 B7Z2C7 O95622
PDB IDs		1KJY 1Y3A 2G83 2GTP 2IK8 2OM2 2PZ3 2XNS 3ONW 3QE0 3QI2 3UMR 3UMS 4G5Q
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Surface Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Signal Transduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Signaling Cell Communication Regulation Of Catalytic Activity Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Cellular Response To Stimulus Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Response To Stimulus Regulation Of Signaling Positive Regulation Of Hydrolase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Sphingosine-1-phosphate Signaling Pathway Regulation Of Cellular Process Chemical Homeostasis Cell-cell Signaling Cytosolic Calcium Ion Homeostasis Positive Regulation Of GTPase Activity Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Synaptic Transmission Negative Regulation Of Signaling Behavior Cellular Metal Ion Homeostasis Neuropeptide Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Cellular Cation Homeostasis Ion Homeostasis Cellular Ion Homeostasis Homeostatic Process Metal Ion Homeostasis Negative Regulation Of Signal Transduction Cellular Chemical Homeostasis Locomotory Behavior Response To Ammonium Ion Negative Regulation Of Ion Transport Response To Cocaine Regulation Of Cell Proliferation Neurological System Process	Regulation Of Phospholipase Activity Platelet Activation Regulation Of Body Fluid Levels Positive Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Energy Reserve Metabolic Process Blood Coagulation Hemostasis Positive Regulation Of Hydrolase Activity Response To Peptide Hormone Renal Water Homeostasis Activation Of Adenylate Cyclase Activity Regulation Of Cardiac Muscle Hypertrophy Response To Peptide Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Adenylate Cyclase Activity Cellular Response To Glucagon Stimulus Negative Regulation Of Insulin Receptor Signaling Pathway Synaptic Transmission Water Transport Histone H3-T6 Phosphorylation Wound Healing Fluid Transport Positive Regulation Of Lyase Activity Positive Regulation Of Myeloid Leukocyte Differentiation Multicellular Organismal Water Homeostasis Activation Of Phospholipase C Activity Response To Glucagon Cell Activation Regulation Of Phosphorus Metabolic Process Regulation Of Insulin Receptor Signaling Pathway Response To Wounding Positive Regulation Of Phospholipase C Activity Regulation Of Glucose Import Regulation Of Adenylate Cyclase Activity Positive Regulation Of Catalytic Activity Regulation Of Protein Kinase Activity Water Homeostasis Positive Regulation Of CAMP Biosynthetic Process Regulation Of Cyclase Activity Regulation Of Kinase Activity Positive Regulation Of CAMP Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Peptide Hormone Stimulus Response To Organonitrogen Compound Regulation Of Cellular Response To Insulin Stimulus Cellular Response To Peptide Negative Regulation Of Protein Phosphorylation Positive Regulation Of Myeloid Cell Differentiation Negative Regulation Of MAP Kinase Activity
Tagcloud ?		alkenes azotic constructions gnao1 heterocycle hm hms htr1b htr2a htr2b htr4 htr6 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkcd prkce prkcg prkd1 propertied pubchem rock2 rps6ka1 rps6ka3 tlr8 tradition	acts dephosphorylating downregulating enhancing extend extends facilitated facilitating foxo3 fractions hif1alpha irs1 lc3b lifespan longevity mir mkp7 mtor pleiotropically pras40 promoted repressed repression rgs2 senescence ser2248 thr246 translocated upregulating
Tagcloud (Difference) ?		alkenes azotic constructions gnao1 heterocycle hm hms htr1b htr2a htr2b htr4 htr6 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkcd prkce prkcg prkd1 propertied pubchem rock2 rps6ka1 rps6ka3 tlr8 tradition	acts dephosphorylating downregulating enhancing extend extends facilitated facilitating foxo3 fractions hif1alpha irs1 lc3b lifespan longevity mir mkp7 mtor pleiotropically pras40 promoted repressed repression rgs2 senescence ser2248 thr246 translocated upregulating
Tagcloud (Intersection) ?