GK and OPLAH

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		GK	OPLAH
Gene Name		glycerol kinase	5-oxoprolinase (ATP-hydrolysing)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrial Outer Membrane Cytosol Extracellular Vesicular Exosome	Cytosol
	Molecular Function	Glycerol Kinase Activity Protein Binding ATP Binding	ATP Binding 5-oxoprolinase (ATP-hydrolyzing) Activity
	Biological Process	Glycerol Metabolic Process Triglyceride Metabolic Process Phosphorylation Triglyceride Biosynthetic Process Glycerol Catabolic Process Glucose Homeostasis Cellular Lipid Metabolic Process Small Molecule Metabolic Process Glycerol-3-phosphate Biosynthetic Process	Glutathione Biosynthetic Process Xenobiotic Metabolic Process Small Molecule Metabolic Process Glutathione Derivative Biosynthetic Process
Pathways		Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Triglyceride Biosynthesis	Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Glutathione synthesis and recycling Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Glutathione conjugation Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GGT1 causes Glutathionuria (GLUTH) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs
Diseases
GWAS			Metabolic traits ( 21886157)
Protein-Protein Interactions		11 interactors: AOX1 APCS CLPTM1L CYP3A4 EIF4G1 FBXO28 GPD1 IPO13 NR4A1 OPLAH RXRA	1 interactors: GK
Entrez ID		2710	26873
HPRD ID		08363	14880
Ensembl ID		ENSG00000198814	ENSG00000178814
Uniprot IDs		B4DH54 P32189	O14841
PDB IDs
Enriched GO Terms of Interacting Partners?		Vitamin Metabolic Process Regulation Of Translational Initiation Glycerophosphate Shuttle Cellular Response To Organic Cyclic Compound Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Positive Regulation Of Translational Initiation By Iron Negative Regulation Of Exo-alpha-sialidase Activity Steroid Hormone Mediated Signaling Pathway Cellular Nitrogen Compound Metabolic Process Alkaloid Catabolic Process Hormone-mediated Signaling Pathway Xenobiotic Metabolic Process Small Molecule Metabolic Process Cellular Response To Xenobiotic Stimulus Cellular Response To Hormone Stimulus Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Response To Xenobiotic Stimulus Vitamin B6 Metabolic Process Glycerol-3-phosphate Catabolic Process Nitrogen Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Monoterpenoid Metabolic Process NADH Oxidation Peroxisome Proliferator Activated Receptor Signaling Pathway Calcitriol Biosynthetic Process From Calciol Cellular Response To Steroid Hormone Stimulus Negative Regulation Of Monocyte Differentiation Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Response To Stimulus Regulation Of Branching Involved In Prostate Gland Morphogenesis Alkaloid Metabolic Process Steroid Metabolic Process Glycerol-3-phosphate Metabolic Process Response To Organic Cyclic Compound Cellular Response To Organic Substance Positive Regulation Of Glycolytic Process Negative Regulation Of Glycoprotein Metabolic Process Regulation Of Translation Oxidative Demethylation Chaperone-mediated Protein Complex Assembly Vitamin D Metabolic Process Muscle Organ Development Response To Hormone Regulation Of Monocyte Differentiation Positive Regulation Of Translational Initiation Endothelial Cell Chemotaxis Negative Regulation Of Acute Inflammatory Response Cellular Lipid Metabolic Process	Glycerol-3-phosphate Biosynthetic Process Glycerol Catabolic Process Glycerol-3-phosphate Metabolic Process Cellular Carbohydrate Catabolic Process Glycerol Metabolic Process Triglyceride Biosynthetic Process Alcohol Catabolic Process Triglyceride Metabolic Process Neutral Lipid Metabolic Process Carbohydrate Catabolic Process Glucose Homeostasis Cellular Carbohydrate Metabolic Process Alcohol Metabolic Process Glycerolipid Metabolic Process Lipid Biosynthetic Process
Tagcloud ?		cask channels clustering coclusters coimmunoprecipitates colocalizes constituent cooh enzymatic fact gkap guanylate heterologous homology isolation junction lin maguk nh2 obscure organization pdz postsynaptic psd sap90 sh3 synaptic termed zo
Tagcloud (Difference) ?		cask channels clustering coclusters coimmunoprecipitates colocalizes constituent cooh enzymatic fact gkap guanylate heterologous homology isolation junction lin maguk nh2 obscure organization pdz postsynaptic psd sap90 sh3 synaptic termed zo
Tagcloud (Intersection) ?