OPLAH

Gene Name		5-oxoprolinase (ATP-hydrolysing)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol
	Molecular Function	ATP Binding 5-oxoprolinase (ATP-hydrolyzing) Activity
	Biological Process	Glutathione Biosynthetic Process Xenobiotic Metabolic Process Small Molecule Metabolic Process Glutathione Derivative Biosynthetic Process
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Glutathione synthesis and recycling Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Glutathione conjugation Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GGT1 causes Glutathionuria (GLUTH) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs
Diseases
GWAS		Metabolic traits ( 21886157)
Protein-protein Interactions		1 interactors: GK
Entrez ID		26873
HPRD ID		14880
Ensembl ID		ENSG00000178814
Uniprot IDs		O14841
PDB IDs
Enriched GO Terms of Interacting Partners?		Glycerol-3-phosphate Biosynthetic Process Glycerol Catabolic Process Glycerol-3-phosphate Metabolic Process Cellular Carbohydrate Catabolic Process Glycerol Metabolic Process Triglyceride Biosynthetic Process Alcohol Catabolic Process Triglyceride Metabolic Process Neutral Lipid Metabolic Process Carbohydrate Catabolic Process Glucose Homeostasis Cellular Carbohydrate Metabolic Process Alcohol Metabolic Process Glycerolipid Metabolic Process Lipid Biosynthetic Process
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