GK and CYP3A4

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		GK	CYP3A4
Gene Name		glycerol kinase	cytochrome P450, family 3, subfamily A, polypeptide 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrial Outer Membrane Cytosol Extracellular Vesicular Exosome	Cytoplasm Endoplasmic Reticulum Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Glycerol Kinase Activity Protein Binding ATP Binding	Monooxygenase Activity Steroid Binding Iron Ion Binding Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxygen Binding Enzyme Binding Heme Binding Vitamin D3 25-hydroxylase Activity Taurochenodeoxycholate 6alpha-hydroxylase Activity Caffeine Oxidase Activity Albendazole Monooxygenase Activity Quinine 3-monooxygenase Activity Testosterone 6-beta-hydroxylase Activity Vitamin D 24-hydroxylase Activity
	Biological Process	Glycerol Metabolic Process Triglyceride Metabolic Process Phosphorylation Triglyceride Biosynthetic Process Glycerol Catabolic Process Glucose Homeostasis Cellular Lipid Metabolic Process Small Molecule Metabolic Process Glycerol-3-phosphate Biosynthetic Process	Lipid Metabolic Process Steroid Catabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Androgen Metabolic Process Alkaloid Catabolic Process Monoterpenoid Metabolic Process Drug Metabolic Process Calcitriol Biosynthetic Process From Calciol Vitamin D Metabolic Process Drug Catabolic Process Exogenous Drug Catabolic Process Small Molecule Metabolic Process Heterocycle Metabolic Process Oxidation-reduction Process Oxidative Demethylation
Pathways		Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Triglyceride Biosynthesis	Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Aflatoxin activation and detoxification Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Metabolic disorders of biological oxidation enzymes Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Phase 1 - Functionalization of compounds Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Xenobiotics Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3) Biological oxidations Defective ACY1 causes encephalopathy
Drugs
Diseases
GWAS			Metabolic traits ( 21886157)
Protein-Protein Interactions		11 interactors: AOX1 APCS CLPTM1L CYP3A4 EIF4G1 FBXO28 GPD1 IPO13 NR4A1 OPLAH RXRA	9 interactors: AMFR CYB5A GK POR PRKACA PRKCA STUB1 UBC UGT2B7
Entrez ID		2710	1576
HPRD ID		08363	00484
Ensembl ID		ENSG00000198814
Uniprot IDs		B4DH54 P32189	P08684 Q6GRK0
PDB IDs			1TQN 1W0E 1W0F 1W0G 2J0D 2V0M 3NXU 3TJS 3UA1 4I3Q 4I4G 4I4H 4K9T 4K9U 4K9V 4K9W 4K9X
Enriched GO Terms of Interacting Partners?		Vitamin Metabolic Process Regulation Of Translational Initiation Glycerophosphate Shuttle Cellular Response To Organic Cyclic Compound Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Positive Regulation Of Translational Initiation By Iron Negative Regulation Of Exo-alpha-sialidase Activity Steroid Hormone Mediated Signaling Pathway Cellular Nitrogen Compound Metabolic Process Alkaloid Catabolic Process Hormone-mediated Signaling Pathway Xenobiotic Metabolic Process Small Molecule Metabolic Process Cellular Response To Xenobiotic Stimulus Cellular Response To Hormone Stimulus Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Response To Xenobiotic Stimulus Vitamin B6 Metabolic Process Glycerol-3-phosphate Catabolic Process Nitrogen Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Monoterpenoid Metabolic Process NADH Oxidation Peroxisome Proliferator Activated Receptor Signaling Pathway Calcitriol Biosynthetic Process From Calciol Cellular Response To Steroid Hormone Stimulus Negative Regulation Of Monocyte Differentiation Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Response To Stimulus Regulation Of Branching Involved In Prostate Gland Morphogenesis Alkaloid Metabolic Process Steroid Metabolic Process Glycerol-3-phosphate Metabolic Process Response To Organic Cyclic Compound Cellular Response To Organic Substance Positive Regulation Of Glycolytic Process Negative Regulation Of Glycoprotein Metabolic Process Regulation Of Translation Oxidative Demethylation Chaperone-mediated Protein Complex Assembly Vitamin D Metabolic Process Muscle Organ Development Response To Hormone Regulation Of Monocyte Differentiation Positive Regulation Of Translational Initiation Endothelial Cell Chemotaxis Negative Regulation Of Acute Inflammatory Response Cellular Lipid Metabolic Process	Positive Regulation Of Dense Core Granule Biogenesis Histone H3-T6 Phosphorylation Cellular Response To Organic Substance Monosaccharide Metabolic Process Small Molecule Metabolic Process Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Response To Organic Substance Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Negative Regulation Of Glucose Import Positive Regulation Of Macrophage Differentiation Desmosome Organization Catabolic Process Energy Reserve Metabolic Process Carbohydrate Metabolic Process Negative Regulation Of Glucose Transport Regulation Of Platelet Aggregation Induction Of Positive Chemotaxis Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Blood Vessel Endothelial Cell Migration Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Lipopolysaccharide-mediated Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Protein Polyubiquitination Negative Regulation Of Adenylate Cyclase Activity Flavonoid Metabolic Process Negative Regulation Of Lyase Activity Cellular Response To Growth Factor Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Rhodopsin Mediated Signaling Pathway Response To Growth Factor Negative Regulation Of CAMP Biosynthetic Process Activation Of Adenylate Cyclase Activity Regulation Of Cardiac Muscle Hypertrophy Neurotrophin TRK Receptor Signaling Pathway Regulation Of Platelet Activation Rhodopsin Mediated Signaling Pathway Positive Regulation Of Positive Chemotaxis Negative Regulation Of CAMP Metabolic Process Regulation Of The Force Of Heart Contraction Neurotrophin Signaling Pathway Inactivation Of MAPK Activity Regulation Of Hormone Metabolic Process Regulation Of Proteolysis Mitotic Nuclear Envelope Disassembly Positive Regulation Of Adenylate Cyclase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?		cask channels clustering coclusters coimmunoprecipitates colocalizes constituent cooh enzymatic fact gkap guanylate heterologous homology isolation junction lin maguk nh2 obscure organization pdz postsynaptic psd sap90 sh3 synaptic termed zo	amiodarone azapropazone carbamazepine cbz clarithromycin cotrimoxazole cyp2c19 cyp2c9 cytochromes disulfiram epoxide felbamate flurythromycin hpph imipramine immunoinhibition josamycin macrolide mephenytoin miconazole omeprazole phenylbutazone pht ponsinomycin propoxyphene secondarily stiripentol sulfaphenazole tolbutamide troleandomycin
Tagcloud (Difference) ?		cask channels clustering coclusters coimmunoprecipitates colocalizes constituent cooh enzymatic fact gkap guanylate heterologous homology isolation junction lin maguk nh2 obscure organization pdz postsynaptic psd sap90 sh3 synaptic termed zo	amiodarone azapropazone carbamazepine cbz clarithromycin cotrimoxazole cyp2c19 cyp2c9 cytochromes disulfiram epoxide felbamate flurythromycin hpph imipramine immunoinhibition josamycin macrolide mephenytoin miconazole omeprazole phenylbutazone pht ponsinomycin propoxyphene secondarily stiripentol sulfaphenazole tolbutamide troleandomycin
Tagcloud (Intersection) ?