BAMBI and BMPR1A

Number of citations of the paper that reports this interaction (PMID 19758997)
21

Data Source:
BioGRID (pull down)

		BAMBI	BMPR1A
Gene Name		BMP and activin membrane-bound inhibitor	bone morphogenetic protein receptor, type IA
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Membrane	Plasma Membrane Caveola Integral Component Of Membrane Dendrite Neuronal Cell Body
	Molecular Function	Frizzled Binding Type II Transforming Growth Factor Beta Receptor Binding	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Protein Binding ATP Binding Protein Homodimerization Activity SMAD Binding Metal Ion Binding
	Biological Process	Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Positive Regulation Of Epithelial To Mesenchymal Transition Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Protein Binding Positive Regulation Of Catenin Import Into Nucleus Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Canonical Wnt Signaling Pathway	In Utero Embryonic Development Mesoderm Formation Somitogenesis Mullerian Duct Regression Positive Regulation Of Mesenchymal Cell Proliferation Endocardial Cushion Formation Transcription From RNA Polymerase II Promoter Protein Phosphorylation Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Ectoderm Development Dorsal/ventral Axis Specification Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Neural Crest Cell Development Stem Cell Maintenance Pituitary Gland Development Neural Plate Mediolateral Regionalization Signal Transduction By Phosphorylation Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Hindlimb Morphogenesis Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Paraxial Mesoderm Structural Organization Lateral Mesoderm Development Regulation Of Lateral Mesodermal Cell Fate Specification Mesendoderm Development Embryonic Organ Development Developmental Growth Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Neurogenesis Cartilage Development Palate Development Positive Regulation Of SMAD Protein Import Into Nucleus Heart Formation Regulation Of Cellular Senescence
Pathways		Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer	Signaling by BMP
Drugs
Diseases
GWAS		Preeclampsia ( 23551011)
Protein-Protein Interactions		8 interactors: ACVR1 ACVR1B ACVRL1 BMPR1A BMPR1B SEP15 SOX30 TGFBR1	23 interactors: ACVR1 BAMBI BMP2 BMP4 BMP5 BMP6 BMP7 BMPR1B BMPR2 FKBP1A FKBP1B GDF5 GDF6 GDF9 HOXC8 NEDD4 NEDD4L SF3B4 SMAD1 TAB1 TGFBRAP1 USP15 ZMYND11
Entrez ID		25805	657
HPRD ID		05117	03192
Ensembl ID		ENSG00000095739
Uniprot IDs		Q13145	P36894
PDB IDs			1ES7 1REW 2GOO 2H62 2H64 2K3G 2QJ9 2QJA 2QJB 3NH7 3QB4
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Signal Transduction By Phosphorylation Activin Receptor Signaling Pathway BMP Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus In Utero Embryonic Development Response To Transforming Growth Factor Beta Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Peptidyl-threonine Phosphorylation Positive Regulation Of Signal Transduction Protein Phosphorylation Reproductive Process Developmental Process Involved In Reproduction Positive Regulation Of Protein Phosphorylation Sex Differentiation Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Regulation Of Cell Differentiation Regulation Of Cartilage Development Positive Regulation Of Cell Differentiation Positive Regulation Of Phosphorylation Tissue Development Positive Regulation Of Ossification Positive Regulation Of Protein Modification Process Regulation Of Transcription From RNA Polymerase II Promoter Phosphorylation Intracellular Signal Transduction Mesenchymal Cell Development Pathway-restricted SMAD Protein Phosphorylation Regulation Of Osteoblast Differentiation Positive Regulation Of SMAD Protein Import Into Nucleus Regulation Of Protein Phosphorylation Mesenchymal Cell Differentiation Pattern Specification Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of SMAD Protein Import Into Nucleus Pharyngeal System Development Embryo Development Positive Regulation Of Epithelial Cell Proliferation Single Organism Reproductive Process Positive Regulation Of Protein Metabolic Process Cellular Response To Growth Factor Stimulus Regulation Of Activin Receptor Signaling Pathway	Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Signal Transduction Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Cartilage Development Positive Regulation Of Bone Mineralization Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Positive Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signaling Cartilage Development Cell Surface Receptor Signaling Pathway Regulation Of RNA Metabolic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Neuron Differentiation Regulation Of Osteoblast Differentiation Regulation Of Signal Transduction Positive Regulation Of Cell Development Regulation Of Bone Mineralization Positive Regulation Of Protein Metabolic Process Connective Tissue Development Regulation Of Gene Expression Regulation Of Neuron Differentiation Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cartilage Development Regulation Of Transcription, DNA-templated Positive Regulation Of Neurogenesis Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Regulation Of Cell Development Regulation Of Phosphorus Metabolic Process Regulation Of Ossification Positive Regulation Of Protein Modification Process Growth Regulation Of Neurogenesis Regulation Of Cell Differentiation Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Response To Organic Substance Skeletal System Development
Tagcloud ?		95th bavaria bavarian breastfed chlorophenyl dde dibenzofurans dichloro hexachlorobenzene hrms mugl musks ngg ngkg ops organochlorine pcbs pcdds pcdfs perfluorinated perfluorooctane pfcs polychlorinated sulfonate tdi teq1998 teq1998g tolerable who1998	abundant adenomatosis apcdd1 bmp5 closure destinies dictated dkk2 e15 edge eyelid eyelids fetuses fgfr2 gli2 identities ie jag1 lcm le microdissection morphogenetic notch1 opening polyposis ptch1 shh smo tip
Tagcloud (Difference) ?		95th bavaria bavarian breastfed chlorophenyl dde dibenzofurans dichloro hexachlorobenzene hrms mugl musks ngg ngkg ops organochlorine pcbs pcdds pcdfs perfluorinated perfluorooctane pfcs polychlorinated sulfonate tdi teq1998 teq1998g tolerable who1998	abundant adenomatosis apcdd1 bmp5 closure destinies dictated dkk2 e15 edge eyelid eyelids fetuses fgfr2 gli2 identities ie jag1 lcm le microdissection morphogenetic notch1 opening polyposis ptch1 shh smo tip
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