BMPR1A and NEDD4L

Number of citations of the paper that reports this interaction (PMID 19953087)
25

Data Source:
BioGRID (pull down)

		BMPR1A	NEDD4L
Gene Name		bone morphogenetic protein receptor, type IA	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
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Gene Ontology Annotations	Cellular Component	Plasma Membrane Caveola Integral Component Of Membrane Dendrite Neuronal Cell Body	Intracellular Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Protein Binding ATP Binding Protein Homodimerization Activity SMAD Binding Metal Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding Potassium Channel Regulator Activity Ligase Activity Sodium Channel Regulator Activity Potassium Channel Inhibitor Activity Sodium Channel Inhibitor Activity Ion Channel Binding
	Biological Process	In Utero Embryonic Development Mesoderm Formation Somitogenesis Mullerian Duct Regression Positive Regulation Of Mesenchymal Cell Proliferation Endocardial Cushion Formation Transcription From RNA Polymerase II Promoter Protein Phosphorylation Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Ectoderm Development Dorsal/ventral Axis Specification Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Neural Crest Cell Development Stem Cell Maintenance Pituitary Gland Development Neural Plate Mediolateral Regionalization Signal Transduction By Phosphorylation Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Hindlimb Morphogenesis Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Paraxial Mesoderm Structural Organization Lateral Mesoderm Development Regulation Of Lateral Mesodermal Cell Fate Specification Mesendoderm Development Embryonic Organ Development Developmental Growth Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Neurogenesis Cartilage Development Palate Development Positive Regulation Of SMAD Protein Import Into Nucleus Heart Formation Regulation Of Cellular Senescence	Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Systemic Arterial Blood Pressure Regulation Of Membrane Depolarization Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Protein Monoubiquitination Sodium Ion Transport Cellular Sodium Ion Homeostasis Transforming Growth Factor Beta Receptor Signaling Pathway Excretion Response To Salt Stress Response To Metal Ion Gene Expression Positive Regulation Of Sodium Ion Transport Viral Process Protein Ubiquitination Viral Life Cycle Water Homeostasis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Regulation Of Protein Catabolic Process Regulation Of Membrane Potential Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Protein Catabolic Process Positive Regulation Of Endocytosis Transmembrane Transport Regulation Of Membrane Repolarization Protein K48-linked Ubiquitination Ventricular Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Protein Localization To Cell Surface Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Tight Junction Assembly Positive Regulation Of Cation Channel Activity Positive Regulation Of Caveolin-mediated Endocytosis
Pathways		Signaling by BMP	Loss of Function of TGFBR2 in Cancer Antigen processing: Ubiquitination & Proteasome degradation HIV Infection SMAD2/3 MH2 Domain Mutants in Cancer Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer HIV Life Cycle Budding and maturation of HIV virion Ion channel transport Generic Transcription Pathway Stimuli-sensing channels Class I MHC mediated antigen processing & presentation TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Late Phase of HIV Life Cycle Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer Adaptive Immune System
Drugs
Diseases
GWAS			Insomnia (caffeine-induced) ( 22754043) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Response to amphetamines ( 22952603)
Protein-Protein Interactions		23 interactors: ACVR1 BAMBI BMP2 BMP4 BMP5 BMP6 BMP7 BMPR1B BMPR2 FKBP1A FKBP1B GDF5 GDF6 GDF9 HOXC8 NEDD4 NEDD4L SF3B4 SMAD1 TAB1 TGFBRAP1 USP15 ZMYND11	126 interactors: AATF ABL1 ABL2 ACVR1B ACY3 ADAP2 AICDA AKT3 APEX2 ARHGDIA AURKC BBX BMPR1A BRAF C7orf50 CACNB1 CAMK1D CDC34 CDK3 CDK5 CLIC2 CUEDC1 CYBRD1 CYP26B1 DAPK3 DAZAP2 DDX54 DECR2 DMTN DYRK3 EFEMP2 FGF12 FKBP3 GORAB H1F0 HAX1 HGS IFRD2 IKBKB KCNAB1 KCNAB2 KCNAB3 KCNB1 KIF3B KIFC3 LAPTM5 MAGEB1 MAP2 MAP3K2 MAP3K3 MAP3K5 MAPKAPK3 MARK2 MERTK MINK1 MOB3A MRPL19 NDFIP2 NHP2 NR3C1 NSRP1 NTRK1 NUDT16L1 PBX1 PRKX PRR16 PRRG1 PSMD4 RANBP10 RASL10B RASL11B RNF11 RNF7 ROBO3 RPL30 RPS6KB2 SCAMP3 SCD SCN5A SCNN1A SCNN1B SCNN1G SENP2 SERPINF1 SGK1 SGK2 SIVA1 SLC7A7 SMAD2 SMAD3 SMAD7 SNCA SPAG8 SRMS STAC STK40 TAF1B TARBP2 TBC1D7 TCEAL2 TGFB1I1 TMA16 TMEM55A TRIM41 UBAC1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E3 UBE2J2 UBE2K UBE2L3 UBE2N VDAC2 WIBG WNK1 WNK4 YWHAG YWHAZ YY1 ZADH2 ZAK ZC3HAV1L ZDHHC3
Entrez ID		657	23327
HPRD ID		03192	05903
Ensembl ID			ENSG00000049759
Uniprot IDs		P36894	B7Z2P9 B7Z6K0 F5H602 Q96PU5
PDB IDs		1ES7 1REW 2GOO 2H62 2H64 2K3G 2QJ9 2QJA 2QJB 3NH7 3QB4	2LAJ 2LB2 2LTY 2NSQ 2ONI 3JVZ 3JW0
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Signal Transduction Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Cartilage Development Positive Regulation Of Bone Mineralization Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Positive Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signaling Cartilage Development Cell Surface Receptor Signaling Pathway Regulation Of RNA Metabolic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Neuron Differentiation Regulation Of Osteoblast Differentiation Regulation Of Signal Transduction Positive Regulation Of Cell Development Regulation Of Bone Mineralization Positive Regulation Of Protein Metabolic Process Connective Tissue Development Regulation Of Gene Expression Regulation Of Neuron Differentiation Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cartilage Development Regulation Of Transcription, DNA-templated Positive Regulation Of Neurogenesis Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Regulation Of Cell Development Regulation Of Phosphorus Metabolic Process Regulation Of Ossification Positive Regulation Of Protein Modification Process Growth Regulation Of Neurogenesis Regulation Of Cell Differentiation Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Response To Organic Substance Skeletal System Development	Cellular Protein Modification Process Protein Phosphorylation Intracellular Signal Transduction Response To Stimulus Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Signaling Regulation Of Signal Transduction Cell Communication Regulation Of Signaling Positive Regulation Of Metabolic Process Protein Polyubiquitination Response To Organic Substance Cellular Response To Stimulus Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Signal Transduction Response To Growth Factor Cellular Response To Organic Substance Protein K48-linked Ubiquitination Regulation Of Cellular Component Organization Enzyme Linked Receptor Protein Signaling Pathway Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Cell Death Regulation Of Apoptotic Process Regulation Of Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Protein Phosphorylation Protein Autophosphorylation Phosphate-containing Compound Metabolic Process Signal Transduction Positive Regulation Of Transferase Activity Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Transport Cellular Response To Growth Factor Stimulus Cellular Metabolic Process Immune System Process Protein Ubiquitination Regulation Of Cellular Process Positive Regulation Of Protein Ubiquitination Cell Death Positive Regulation Of Programmed Cell Death Regulation Of Phosphorus Metabolic Process Death Regulation Of Cellular Component Movement
Tagcloud ?		abundant adenomatosis apcdd1 bmp5 closure destinies dictated dkk2 e15 edge eyelid eyelids fetuses fgfr2 gli2 identities ie jag1 lcm le microdissection morphogenetic notch1 opening polyposis ptch1 shh smo tip	2cl antihypertensive cotransporter defective demonstrating emerging enac exchanger highlight hypertension interactor interesting liddle ligase makes na ncc nephron nhe3 nkcc2 originally progress salt sensitive thiazide transporters ubiquitin ubiquitylates
Tagcloud (Difference) ?		abundant adenomatosis apcdd1 bmp5 closure destinies dictated dkk2 e15 edge eyelid eyelids fetuses fgfr2 gli2 identities ie jag1 lcm le microdissection morphogenetic notch1 opening polyposis ptch1 shh smo tip	2cl antihypertensive cotransporter defective demonstrating emerging enac exchanger highlight hypertension interactor interesting liddle ligase makes na ncc nephron nhe3 nkcc2 originally progress salt sensitive thiazide transporters ubiquitin ubiquitylates
Tagcloud (Intersection) ?