BMPR1A and GDF6

Number of citations of the paper that reports this interaction (PMID 9525338)
18

Data Source:
HPRD (in vitro)

		BMPR1A	GDF6
Gene Name		bone morphogenetic protein receptor, type IA	growth differentiation factor 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Caveola Integral Component Of Membrane Dendrite Neuronal Cell Body	Extracellular Space
	Molecular Function	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Protein Binding ATP Binding Protein Homodimerization Activity SMAD Binding Metal Ion Binding	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Growth Factor Activity Protein Homodimerization Activity
	Biological Process	In Utero Embryonic Development Mesoderm Formation Somitogenesis Mullerian Duct Regression Positive Regulation Of Mesenchymal Cell Proliferation Endocardial Cushion Formation Transcription From RNA Polymerase II Promoter Protein Phosphorylation Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Ectoderm Development Dorsal/ventral Axis Specification Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Neural Crest Cell Development Stem Cell Maintenance Pituitary Gland Development Neural Plate Mediolateral Regionalization Signal Transduction By Phosphorylation Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Hindlimb Morphogenesis Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Paraxial Mesoderm Structural Organization Lateral Mesoderm Development Regulation Of Lateral Mesodermal Cell Fate Specification Mesendoderm Development Embryonic Organ Development Developmental Growth Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Neurogenesis Cartilage Development Palate Development Positive Regulation Of SMAD Protein Import Into Nucleus Heart Formation Regulation Of Cellular Senescence	Apoptotic Process Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway Activin Receptor Signaling Pathway Growth Regulation Of Apoptotic Process Regulation Of MAPK Cascade Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Cell Development Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Retinal Cell Apoptotic Process
Pathways		Signaling by BMP
Drugs
Diseases
GWAS
Protein-Protein Interactions		23 interactors: ACVR1 BAMBI BMP2 BMP4 BMP5 BMP6 BMP7 BMPR1B BMPR2 FKBP1A FKBP1B GDF5 GDF6 GDF9 HOXC8 NEDD4 NEDD4L SF3B4 SMAD1 TAB1 TGFBRAP1 USP15 ZMYND11	5 interactors: BMPR1A BMPR1B BMPR2 SMAD1 SMAD5
Entrez ID		657	392255
HPRD ID		03192	11002
Ensembl ID			ENSG00000156466
Uniprot IDs		P36894	Q6KF10
PDB IDs		1ES7 1REW 2GOO 2H62 2H64 2K3G 2QJ9 2QJA 2QJB 3NH7 3QB4
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Signal Transduction Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Cartilage Development Positive Regulation Of Bone Mineralization Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Positive Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signaling Cartilage Development Cell Surface Receptor Signaling Pathway Regulation Of RNA Metabolic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Neuron Differentiation Regulation Of Osteoblast Differentiation Regulation Of Signal Transduction Positive Regulation Of Cell Development Regulation Of Bone Mineralization Positive Regulation Of Protein Metabolic Process Connective Tissue Development Regulation Of Gene Expression Regulation Of Neuron Differentiation Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cartilage Development Regulation Of Transcription, DNA-templated Positive Regulation Of Neurogenesis Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Regulation Of Cell Development Regulation Of Phosphorus Metabolic Process Regulation Of Ossification Positive Regulation Of Protein Modification Process Growth Regulation Of Neurogenesis Regulation Of Cell Differentiation Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Response To Organic Substance Skeletal System Development	Positive Regulation Of Osteoblast Differentiation BMP Signaling Pathway Positive Regulation Of Ossification Regulation Of Osteoblast Differentiation Cartilage Development Regulation Of Ossification Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Connective Tissue Development Pattern Specification Process Skeletal System Development Negative Regulation Of Chondrocyte Proliferation Bone Development Positive Regulation Of Cartilage Development Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Cell Differentiation Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction By Phosphorylation Regulation Of Bone Mineralization Osteoblast Fate Commitment Mullerian Duct Regression Mesoderm Formation Regulation Of Cartilage Development Mesoderm Morphogenesis Protein Phosphorylation Regulation Of Cell Differentiation Formation Of Primary Germ Layer Transforming Growth Factor Beta Receptor Signaling Pathway Mesoderm Development Tissue Development Regulation Of Transcription From RNA Polymerase II Promoter Phosphorylation Intracellular Signal Transduction Tube Development Anatomical Structure Regression Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Gastrulation Cellular Response To BMP Stimulus Limb Development Anatomical Structure Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Sex Differentiation Chondrocyte Development Epithelium Development Embryo Development Phosphate-containing Compound Metabolic Process Single Organism Reproductive Process Organ Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Tagcloud ?		abundant adenomatosis apcdd1 bmp5 closure destinies dictated dkk2 e15 edge eyelid eyelids fetuses fgfr2 gli2 identities ie jag1 lcm le microdissection morphogenetic notch1 opening polyposis ptch1 shh smo tip	amongst argue bigenic bmp broadened broader degenerative disrupt disrupted effecting endurance gdf6a harboring junctions larval modifier morphogenetic neuromuscular nmj noting progressively siblings sod1 suite synergize vertebrate vertebrates worsened
Tagcloud (Difference) ?		abundant adenomatosis apcdd1 bmp5 closure destinies dictated dkk2 e15 edge eyelid eyelids fetuses fgfr2 gli2 identities ie jag1 lcm le microdissection notch1 opening polyposis ptch1 shh smo tip	amongst argue bigenic bmp broadened broader degenerative disrupt disrupted effecting endurance gdf6a harboring junctions larval modifier neuromuscular nmj noting progressively siblings sod1 suite synergize vertebrate vertebrates worsened
Tagcloud (Intersection) ?		morphogenetic