ACKR1 and CCL7

Number of citations of the paper that reports this interaction (PMID 13679391)
13

Data Source:
HPRD (in vivo)

		ACKR1	CCL7
Gene Name		atypical chemokine receptor 1 (Duffy blood group)	chemokine (C-C motif) ligand 7
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Early Endosome Plasma Membrane Integral Component Of Membrane Recycling Endosome	Extracellular Region Extracellular Space
	Molecular Function	Receptor Activity Transmembrane Signaling Receptor Activity G-protein Coupled Receptor Activity C-C Chemokine Binding	Chemokine Activity Heparin Binding CCR1 Chemokine Receptor Binding CCR2 Chemokine Receptor Binding
	Biological Process	Defense Response Inflammatory Response G-protein Coupled Receptor Signaling Pathway Regulation Of Chemokine Production Chemokine-mediated Signaling Pathway	Monocyte Chemotaxis Cellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Immune Response Cytoskeleton Organization Signal Transduction Cell-cell Signaling Regulation Of Cell Shape Response To Gamma Radiation Positive Regulation Of Cell Migration Eosinophil Chemotaxis Cellular Response To Ethanol Positive Regulation Of Natural Killer Cell Chemotaxis
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS			Crohn's disease ( 22412388 21102463)
Protein-Protein Interactions		8 interactors: CCL17 CCL2 CCL5 CCL7 CCL8 CXCL1 CXCL5 CXCL8	15 interactors: ACKR1 ACKR2 ACKR4 AES CCR1 CCR10 CCR3 CCR5 FEZ1 MMP1 MMP13 MMP14 MMP2 MMP3 UBQLN1
Entrez ID		2532	6354
HPRD ID		00192	01150
Ensembl ID		ENSG00000213088	ENSG00000108688
Uniprot IDs		Q16570 Q5Y7A1 Q5Y7A2	P80098
PDB IDs			1BO0 1NCV
Enriched GO Terms of Interacting Partners?		Cell Chemotaxis Inflammatory Response Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Leukocyte Migration Chemotaxis Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Positive Regulation Of Behavior Regulation Of Chemotaxis Cell Migration Chemokine-mediated Signaling Pathway Cell Motility Regulation Of Behavior Locomotion Immune Response Defense Response Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Movement Of Cell Or Subcellular Component Positive Regulation Of Locomotion Response To External Stimulus Granulocyte Chemotaxis Immune System Process Regulation Of Cell Migration Regulation Of Cell Motility Monocyte Chemotaxis Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Other Organism Response To Lipopolysaccharide Leukocyte Chemotaxis Response To Biotic Stimulus Response To Molecule Of Bacterial Origin Positive Regulation Of Immune System Process Regulation Of Lymphocyte Migration Cytokine-mediated Signaling Pathway Response To Bacterium Regulation Of Granulocyte Chemotaxis Response To Stress G-protein Coupled Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Leukocyte Migration Regulation Of Immune System Process Cellular Response To Interleukin-1 Positive Regulation Of Natural Killer Cell Chemotaxis Response To Cytokine Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Positive Regulation Of Macrophage Chemotaxis	Chemokine-mediated Signaling Pathway Collagen Catabolic Process Locomotion Response To Organic Substance Chemotaxis Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Response To Cytokine Cytokine-mediated Signaling Pathway Response To External Stimulus Cellular Response To Organic Substance Cellular Response To Cytokine Stimulus Inflammatory Response Response To Stress Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Cytosolic Calcium Ion Concentration G-protein Coupled Receptor Signaling Pathway Response To Stimulus Cytosolic Calcium Ion Homeostasis Cell Surface Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Dendritic Cell Chemotaxis Cellular Response To Stimulus Positive Regulation Of Protein Oligomerization Neutrophil Activation Cellular Metal Ion Homeostasis Defense Response Dendritic Cell Migration Cellular Cation Homeostasis Regulation Of Protein Oligomerization Cellular Ion Homeostasis Metal Ion Homeostasis Movement Of Cell Or Subcellular Component Endodermal Cell Differentiation Cellular Chemical Homeostasis Skeletal System Development Endochondral Ossification Ion Homeostasis Leukocyte Migration Regulation Of Cellular Response To Oxidative Stress Regulation Of Cellular Process Cellular Defense Response Endoderm Formation Skeletal System Morphogenesis Cellular Response To Amino Acid Stimulus Ossification
Tagcloud ?			backgroundmonocyte ccl3 ccl4 cd45 chemokines conclusionsour contrasted contributors cxcl1 cxcl10 degenerating degenerations deoxynucleotidyl dutp euthanized facs govern ld lux markdawley methodssprague muller nick photoreceptor pigment resultsexposure retinal retinas rpe
Tagcloud (Difference) ?			backgroundmonocyte ccl3 ccl4 cd45 chemokines conclusionsour contrasted contributors cxcl1 cxcl10 degenerating degenerations deoxynucleotidyl dutp euthanized facs govern ld lux markdawley methodssprague muller nick photoreceptor pigment resultsexposure retinal retinas rpe
Tagcloud (Intersection) ?