CCL7 and AES

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		CCL7	AES
Gene Name		chemokine (C-C motif) ligand 7	amino-terminal enhancer of split
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Nucleus
	Molecular Function	Chemokine Activity Heparin Binding CCR1 Chemokine Receptor Binding CCR2 Chemokine Receptor Binding	Transcription Corepressor Activity Protein Binding
	Biological Process	Monocyte Chemotaxis Cellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Immune Response Cytoskeleton Organization Signal Transduction Cell-cell Signaling Regulation Of Cell Shape Response To Gamma Radiation Positive Regulation Of Cell Migration Eosinophil Chemotaxis Cellular Response To Ethanol Positive Regulation Of Natural Killer Cell Chemotaxis	Negative Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Development Transcription, DNA-templated Multicellular Organismal Development Organ Morphogenesis Negative Regulation Of Gene Expression Wnt Signaling Pathway Cellular Response To Extracellular Stimulus Negative Regulation Of Protein Binding Regulation Of Growth Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Response To Cytokine Stimulus Response To Interleukin-1 Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Anoikis
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Signaling by Wnt repression of WNT target genes APC truncation mutants are not K63 polyubiquitinated S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer truncations of AMER1 destabilize the destruction complex
Drugs
Diseases
GWAS		Crohn's disease ( 22412388 21102463)
Protein-Protein Interactions		15 interactors: ACKR1 ACKR2 ACKR4 AES CCR1 CCR10 CCR3 CCR5 FEZ1 MMP1 MMP13 MMP14 MMP2 MMP3 UBQLN1	138 interactors: ABI2 AEN AR ARHGAP32 ATN1 BAHD1 BCL6 BHLHE40 BIRC7 BYSL C1orf109 C1orf216 C1orf94 C6orf165 CALCOCO2 CAPN1 CARD9 CCDC57 CCL7 CCNJL CCNK CIB3 CPSF7 CRACR2A CRX CTAGE5 DDX6 DGCR6 DIP2A EAF1 EIF4E2 FAM124A FAM124B FBF1 FOXP2 FRS3 FSD2 GABARAP GFAP GFI1B GOLGA2 GORASP2 GRB2 GTF2E1 HMGB1 HNF1A HNRNPF HOMEZ IKZF3 KANK2 KIFC3 KRT13 KRT15 KRT31 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 L3MBTL2 LDOC1 LINC00526 LMO1 LMO2 LMO4 LSM2 MAGOHB MAPK14 MBNL1 MED31 MED4 MFAP1 MLX MORF4L2 MSX1 MTUS2 MVP MYO15B NAB2 NCDN NEK6 NOTCH2NL NUDT22 OLIG3 OSGIN1 PARVG POU2F1 PPP1R16A PRDM1 PRKAA1 PRKAA2 PRPF31 PRR3 PTRH2 QARS RBM10 RBPMS REL RELA RFX6 RHOXF2 RIMBP3 RNF31 RPL18A RUNX1 SCNM1 SDCBP SH3GL3 SIX1 SIX2 SIX3 SIX6 SKIL SMAD3 SNCAIP SNRPC SOX5 SRPK2 STK16 STX11 TBX3 TCF4 TMCC2 TRAF1 TRAF2 TRIM26 TRIM27 TRIM41 TSC22D4 TSGA10 TSSK3 U2AF2 UBXN11 VPS37B VPS37C ZBTB24 ZGPAT ZNF576
Entrez ID		6354	166
HPRD ID		01150	02556
Ensembl ID		ENSG00000108688	ENSG00000104964
Uniprot IDs		P80098	Q08117 Q8WY48
PDB IDs		1BO0 1NCV
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Collagen Catabolic Process Locomotion Response To Organic Substance Chemotaxis Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Response To Cytokine Cytokine-mediated Signaling Pathway Response To External Stimulus Cellular Response To Organic Substance Cellular Response To Cytokine Stimulus Inflammatory Response Response To Stress Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Cytosolic Calcium Ion Concentration G-protein Coupled Receptor Signaling Pathway Response To Stimulus Cytosolic Calcium Ion Homeostasis Cell Surface Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Dendritic Cell Chemotaxis Cellular Response To Stimulus Positive Regulation Of Protein Oligomerization Neutrophil Activation Cellular Metal Ion Homeostasis Defense Response Dendritic Cell Migration Cellular Cation Homeostasis Regulation Of Protein Oligomerization Cellular Ion Homeostasis Metal Ion Homeostasis Movement Of Cell Or Subcellular Component Endodermal Cell Differentiation Cellular Chemical Homeostasis Skeletal System Development Endochondral Ossification Ion Homeostasis Leukocyte Migration Regulation Of Cellular Response To Oxidative Stress Regulation Of Cellular Process Cellular Defense Response Endoderm Formation Skeletal System Morphogenesis Cellular Response To Amino Acid Stimulus Ossification	RNA Metabolic Process Gene Expression Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Heterocycle Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Cellular Process Multicellular Organismal Development Cellular Metabolic Process Developmental Process Anatomical Structure Development Positive Regulation Of Cellular Biosynthetic Process Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Organ Morphogenesis Embryo Development Tissue Development RNA Processing RNA Splicing In Utero Embryonic Development Regulation Of Cell Death Organ Development
Tagcloud ?		backgroundmonocyte ccl3 ccl4 cd45 chemokines conclusionsour contrasted contributors cxcl1 cxcl10 degenerating degenerations deoxynucleotidyl dutp euthanized facs govern ld lux markdawley methodssprague muller nick photoreceptor pigment resultsexposure retinal retinas rpe	auger bonefit branemark depths differently friatec germany goteborg implants imz mannheim nobelpharma osseointegrated osseointegration outermost peaks photoelectron pure shifted spectroscopy speculated spray straumann sweden switzerland tio2 titanium waldenburg xps
Tagcloud (Difference) ?		backgroundmonocyte ccl3 ccl4 cd45 chemokines conclusionsour contrasted contributors cxcl1 cxcl10 degenerating degenerations deoxynucleotidyl dutp euthanized facs govern ld lux markdawley methodssprague muller nick photoreceptor pigment resultsexposure retinal retinas rpe	auger bonefit branemark depths differently friatec germany goteborg implants imz mannheim nobelpharma osseointegrated osseointegration outermost peaks photoelectron pure shifted spectroscopy speculated spray straumann sweden switzerland tio2 titanium waldenburg xps
Tagcloud (Intersection) ?