ACKR1 and CCL5

Number of citations of the paper that reports this interaction (PMID 17416748)
21

Data Source:
HPRD (in vivo, in vitro)

		ACKR1	CCL5
Gene Name		atypical chemokine receptor 1 (Duffy blood group)	chemokine (C-C motif) ligand 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Early Endosome Plasma Membrane Integral Component Of Membrane Recycling Endosome	Extracellular Region Extracellular Space Cytoplasm
	Molecular Function	Receptor Activity Transmembrane Signaling Receptor Activity G-protein Coupled Receptor Activity C-C Chemokine Binding	Phosphatidylinositol Phospholipase C Activity Protein Kinase Activity Protein Binding Chemokine Activity Phospholipase Activator Activity Receptor Signaling Protein Tyrosine Kinase Activator Activity CCR1 Chemokine Receptor Binding CCR4 Chemokine Receptor Binding CCR5 Chemokine Receptor Binding Chemoattractant Activity Chemokine Receptor Binding Protein Homodimerization Activity Protein Self-association Chemokine Receptor Antagonist Activity
	Biological Process	Defense Response Inflammatory Response G-protein Coupled Receptor Signaling Pathway Regulation Of Chemokine Production Chemokine-mediated Signaling Pathway	MAPK Cascade Dendritic Cell Chemotaxis Monocyte Chemotaxis Regulation Of Chronic Inflammatory Response Protein Phosphorylation Calcium Ion Transport Cellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Leukocyte Cell-cell Adhesion G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Response To Virus Response To Toxic Substance Positive Regulation Of Activation Of JAK2 Kinase Activity Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of T Cell Chemotaxis Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Cellular Biosynthetic Process Activation Of Phospholipase D Activity Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of T Cell Proliferation Neutrophil Activation Positive Regulation Of Phosphorylation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Protein Kinase B Signaling Cellular Protein Complex Assembly Negative Regulation By Host Of Viral Transcription Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Positive Regulation Of Innate Immune Response Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Cell Adhesion Positive Regulation Of Translational Initiation Positive Regulation Of JAK-STAT Cascade Eosinophil Chemotaxis Macrophage Chemotaxis Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Regulation Of Insulin Secretion Regulation Of T Cell Activation Positive Chemotaxis Protein Tetramerization Positive Regulation Of Calcium Ion Transport Positive Regulation Of Protein Tyrosine Kinase Activity Chemokine-mediated Signaling Pathway Negative Regulation Of Chemokine-mediated Signaling Pathway Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of T Cell Apoptotic Process Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Organic Cyclic Compound Positive Regulation Of Monocyte Chemotaxis Regulation Of Neuron Death Negative Regulation Of Macrophage Apoptotic Process Positive Regulation Of T Cell Migration Positive Regulation Of Natural Killer Cell Chemotaxis
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Heparin Disaccharide I-S Heparin Disaccharide Iii-S
Diseases
GWAS
Protein-Protein Interactions		8 interactors: CCL17 CCL2 CCL5 CCL7 CCL8 CXCL1 CXCL5 CXCL8	21 interactors: ACKR1 ACKR2 ACKR4 CCR1 CCR3 CCR4 CCR5 CXCL8 DPP4 EDC4 GRB2 IGFBP7 PF4 PIGR RANGAP1 RELA SDC1 SDC4 SLC2A5 TRIP6 VCAN
Entrez ID		2532	6352
HPRD ID		00192	01751
Ensembl ID		ENSG00000213088	ENSG00000161570
Uniprot IDs		Q16570 Q5Y7A1 Q5Y7A2	D0EI67 P13501
PDB IDs			1B3A 1EQT 1HRJ 1RTN 1RTO 1U4L 1U4M 1U4P 1U4R 2L9H 2VXW
Enriched GO Terms of Interacting Partners?		Cell Chemotaxis Inflammatory Response Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Leukocyte Migration Chemotaxis Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Positive Regulation Of Behavior Regulation Of Chemotaxis Cell Migration Chemokine-mediated Signaling Pathway Cell Motility Regulation Of Behavior Locomotion Immune Response Defense Response Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Movement Of Cell Or Subcellular Component Positive Regulation Of Locomotion Response To External Stimulus Granulocyte Chemotaxis Immune System Process Regulation Of Cell Migration Regulation Of Cell Motility Monocyte Chemotaxis Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Other Organism Response To Lipopolysaccharide Leukocyte Chemotaxis Response To Biotic Stimulus Response To Molecule Of Bacterial Origin Positive Regulation Of Immune System Process Regulation Of Lymphocyte Migration Cytokine-mediated Signaling Pathway Response To Bacterium Regulation Of Granulocyte Chemotaxis Response To Stress G-protein Coupled Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Leukocyte Migration Regulation Of Immune System Process Cellular Response To Interleukin-1 Positive Regulation Of Natural Killer Cell Chemotaxis Response To Cytokine Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Positive Regulation Of Macrophage Chemotaxis	Chemokine-mediated Signaling Pathway Inflammatory Response Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Response To Cytokine Cellular Response To Organic Substance Chemotaxis Response To Organic Substance Locomotion Defense Response Response To External Stimulus Immune Response Cellular Response To Stimulus Response To Stimulus Signal Transduction G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Cell Migration Immune System Process Cell Motility Signaling Cell Communication Response To Stress Leukocyte Migration Positive Regulation Of Organelle Assembly Leukocyte Chemotaxis Positive Regulation Of Chemotaxis Positive Regulation Of Extracellular Vesicular Exosome Assembly Positive Regulation Of Behavior Response To Lipid Regulation Of Chemotaxis Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Regulation Of Extracellular Vesicular Exosome Assembly Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Locomotion Cell Chemotaxis Cellular Defense Response Glycosaminoglycan Catabolic Process Cytosolic Calcium Ion Homeostasis Chondroitin Sulfate Metabolic Process Regulation Of Behavior Movement Of Cell Or Subcellular Component Response To Abiotic Stimulus Positive Regulation Of Leukocyte Chemotaxis Pathogenesis Response To Radiation Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Response To Bacterium
Tagcloud ?			adaptor amplifies antagonism bdl bile binder broad chemokine conditional contributor duct elucidate exacerbated fibrogenesis fibrosis fibrotic gab1 gab1cko grb2 hepatocyte hepatocytes injections knockout ligation lipopolysaccharide liver livers myofibroblasts tetrachloride
Tagcloud (Difference) ?			adaptor amplifies antagonism bdl bile binder broad chemokine conditional contributor duct elucidate exacerbated fibrogenesis fibrosis fibrotic gab1 gab1cko grb2 hepatocyte hepatocytes injections knockout ligation lipopolysaccharide liver livers myofibroblasts tetrachloride
Tagcloud (Intersection) ?