CCL7 and ACKR4

Number of citations of the paper that reports this interaction (PMID 10734104)
12

Data Source:
HPRD (in vitro)

		CCL7	ACKR4
Gene Name		chemokine (C-C motif) ligand 7	atypical chemokine receptor 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Early Endosome Plasma Membrane Integral Component Of Plasma Membrane Recycling Endosome
	Molecular Function	Chemokine Activity Heparin Binding CCR1 Chemokine Receptor Binding CCR2 Chemokine Receptor Binding	Chemokine Receptor Activity Scavenger Receptor Activity Protein Binding Chemokine Binding
	Biological Process	Monocyte Chemotaxis Cellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Immune Response Cytoskeleton Organization Signal Transduction Cell-cell Signaling Regulation Of Cell Shape Response To Gamma Radiation Positive Regulation Of Cell Migration Eosinophil Chemotaxis Cellular Response To Ethanol Positive Regulation Of Natural Killer Cell Chemotaxis	Receptor-mediated Endocytosis Chemotaxis Immune Response G-protein Coupled Receptor Signaling Pathway Chemokine-mediated Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Crohn's disease ( 22412388 21102463)
Protein-Protein Interactions		15 interactors: ACKR1 ACKR2 ACKR4 AES CCR1 CCR10 CCR3 CCR5 FEZ1 MMP1 MMP13 MMP14 MMP2 MMP3 UBQLN1	11 interactors: CCL11 CCL13 CCL19 CCL2 CCL21 CCL25 CCL5 CCL7 CCL8 CDK2 CXCL13
Entrez ID		6354	51554
HPRD ID		01150	07298
Ensembl ID		ENSG00000108688	ENSG00000129048
Uniprot IDs		P80098	Q9NPB9
PDB IDs		1BO0 1NCV
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Collagen Catabolic Process Locomotion Response To Organic Substance Chemotaxis Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Response To Cytokine Cytokine-mediated Signaling Pathway Response To External Stimulus Cellular Response To Organic Substance Cellular Response To Cytokine Stimulus Inflammatory Response Response To Stress Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Cytosolic Calcium Ion Concentration G-protein Coupled Receptor Signaling Pathway Response To Stimulus Cytosolic Calcium Ion Homeostasis Cell Surface Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Dendritic Cell Chemotaxis Cellular Response To Stimulus Positive Regulation Of Protein Oligomerization Neutrophil Activation Cellular Metal Ion Homeostasis Defense Response Dendritic Cell Migration Cellular Cation Homeostasis Regulation Of Protein Oligomerization Cellular Ion Homeostasis Metal Ion Homeostasis Movement Of Cell Or Subcellular Component Endodermal Cell Differentiation Cellular Chemical Homeostasis Skeletal System Development Endochondral Ossification Ion Homeostasis Leukocyte Migration Regulation Of Cellular Response To Oxidative Stress Regulation Of Cellular Process Cellular Defense Response Endoderm Formation Skeletal System Morphogenesis Cellular Response To Amino Acid Stimulus Ossification	Cell Chemotaxis Leukocyte Chemotaxis Leukocyte Migration Inflammatory Response Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Chemotaxis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Regulation Of Leukocyte Migration Cellular Ion Homeostasis Metal Ion Homeostasis Cell Migration Cell Motility Cellular Chemical Homeostasis Ion Homeostasis Positive Regulation Of Leukocyte Chemotaxis Cellular Homeostasis Positive Regulation Of Leukocyte Migration Regulation Of Lymphocyte Migration Locomotion Eosinophil Chemotaxis Immune Response Eosinophil Migration Defense Response Positive Regulation Of Chemotaxis Chemical Homeostasis Positive Regulation Of Behavior Movement Of Cell Or Subcellular Component Regulation Of Chemotaxis Regulation Of Cell Migration Positive Regulation Of Cell Migration Granulocyte Chemotaxis Positive Regulation Of Cell Motility Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of Locomotion Response To External Stimulus Regulation Of Cellular Component Movement Regulation Of Behavior Homeostatic Process Immune System Process Response To Stress Regulation Of Granulocyte Chemotaxis Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Dendritic Cell Chemotaxis Monocyte Chemotaxis Positive Regulation Of Cell-cell Adhesion
Tagcloud ?		backgroundmonocyte ccl3 ccl4 cd45 chemokines conclusionsour contrasted contributors cxcl1 cxcl10 degenerating degenerations deoxynucleotidyl dutp euthanized facs govern ld lux markdawley methodssprague muller nick photoreceptor pigment resultsexposure retinal retinas rpe
Tagcloud (Difference) ?		backgroundmonocyte ccl3 ccl4 cd45 chemokines conclusionsour contrasted contributors cxcl1 cxcl10 degenerating degenerations deoxynucleotidyl dutp euthanized facs govern ld lux markdawley methodssprague muller nick photoreceptor pigment resultsexposure retinal retinas rpe
Tagcloud (Intersection) ?