CCL5 and SDC1

Number of citations of the paper that reports this interaction (PMID 14637022)
10

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		CCL5	SDC1
Gene Name		chemokine (C-C motif) ligand 5	syndecan 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Cytoplasm Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Lysosomal Lumen Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Protein Kinase Activity Protein Binding Chemokine Activity Phospholipase Activator Activity Receptor Signaling Protein Tyrosine Kinase Activator Activity CCR1 Chemokine Receptor Binding CCR4 Chemokine Receptor Binding CCR5 Chemokine Receptor Binding Chemoattractant Activity Chemokine Receptor Binding Protein Homodimerization Activity Protein Self-association Chemokine Receptor Antagonist Activity	Glycoprotein Binding Protein Binding Protein C-terminus Binding
	Biological Process	MAPK Cascade Dendritic Cell Chemotaxis Monocyte Chemotaxis Regulation Of Chronic Inflammatory Response Protein Phosphorylation Calcium Ion Transport Cellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Leukocyte Cell-cell Adhesion G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Response To Virus Response To Toxic Substance Positive Regulation Of Activation Of JAK2 Kinase Activity Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of T Cell Chemotaxis Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Cellular Biosynthetic Process Activation Of Phospholipase D Activity Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of T Cell Proliferation Neutrophil Activation Positive Regulation Of Phosphorylation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Protein Kinase B Signaling Cellular Protein Complex Assembly Negative Regulation By Host Of Viral Transcription Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Positive Regulation Of Innate Immune Response Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Cell Adhesion Positive Regulation Of Translational Initiation Positive Regulation Of JAK-STAT Cascade Eosinophil Chemotaxis Macrophage Chemotaxis Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Regulation Of Insulin Secretion Regulation Of T Cell Activation Positive Chemotaxis Protein Tetramerization Positive Regulation Of Calcium Ion Transport Positive Regulation Of Protein Tyrosine Kinase Activity Chemokine-mediated Signaling Pathway Negative Regulation Of Chemokine-mediated Signaling Pathway Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of T Cell Apoptotic Process Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Organic Cyclic Compound Positive Regulation Of Monocyte Chemotaxis Regulation Of Neuron Death Negative Regulation Of Macrophage Apoptotic Process Positive Regulation Of T Cell Migration Positive Regulation Of Natural Killer Cell Chemotaxis	Retinoid Metabolic Process Ureteric Bud Development Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Inflammatory Response Phototransduction, Visible Light Pathogenesis Response To Toxic Substance Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Wound Healing Lipoprotein Metabolic Process Odontogenesis Response To Hydrogen Peroxide Small Molecule Metabolic Process Myoblast Development Response To Glucocorticoid Response To CAMP Response To Calcium Ion Striated Muscle Cell Development Sertoli Cell Development Canonical Wnt Signaling Pathway Positive Regulation Of Exosomal Secretion Positive Regulation Of Extracellular Vesicular Exosome Assembly
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Lipoprotein metabolism MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type Metabolism of lipids and lipoproteins Heparan sulfate/heparin (HS-GAG) metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chylomicron-mediated lipid transport Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis MPS IIIC - Sanfilippo syndrome C Retinoid metabolism and transport Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Non-integrin membrane-ECM interactions Lipid digestion, mobilization, and transport Defective EXT1 causes exostoses 1, TRPS2 and CHDS Diseases associated with visual transduction MPS IV - Morquio syndrome A Syndecan interactions Visual phototransduction MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates HS-GAG biosynthesis HS-GAG degradation MPS VI - Maroteaux-Lamy syndrome
Drugs		Heparin Disaccharide I-S Heparin Disaccharide Iii-S
Diseases
GWAS
Protein-Protein Interactions		21 interactors: ACKR1 ACKR2 ACKR4 CCR1 CCR3 CCR4 CCR5 CXCL8 DPP4 EDC4 GRB2 IGFBP7 PF4 PIGR RANGAP1 RELA SDC1 SDC4 SLC2A5 TRIP6 VCAN	15 interactors: APP CASK CCL5 CD63 CTSG CXCL8 ELANE FGF2 HGF IGFBP7 LACRT MDK MMP14 PTN SDCBP
Entrez ID		6352	6382
HPRD ID		01751	01718
Ensembl ID		ENSG00000161570	ENSG00000115884
Uniprot IDs		D0EI67 P13501	P18827
PDB IDs		1B3A 1EQT 1HRJ 1RTN 1RTO 1U4L 1U4M 1U4P 1U4R 2L9H 2VXW	4GVC 4GVD
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Inflammatory Response Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Response To Cytokine Cellular Response To Organic Substance Chemotaxis Response To Organic Substance Locomotion Defense Response Response To External Stimulus Immune Response Cellular Response To Stimulus Response To Stimulus Signal Transduction G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Cell Migration Immune System Process Cell Motility Signaling Cell Communication Response To Stress Leukocyte Migration Positive Regulation Of Organelle Assembly Leukocyte Chemotaxis Positive Regulation Of Chemotaxis Positive Regulation Of Extracellular Vesicular Exosome Assembly Positive Regulation Of Behavior Response To Lipid Regulation Of Chemotaxis Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Regulation Of Extracellular Vesicular Exosome Assembly Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Locomotion Cell Chemotaxis Cellular Defense Response Glycosaminoglycan Catabolic Process Cytosolic Calcium Ion Homeostasis Chondroitin Sulfate Metabolic Process Regulation Of Behavior Movement Of Cell Or Subcellular Component Response To Abiotic Stimulus Positive Regulation Of Leukocyte Chemotaxis Pathogenesis Response To Radiation Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Response To Bacterium	Cell Migration Locomotion Cell Motility Positive Regulation Of Cellular Metabolic Process Movement Of Cell Or Subcellular Component Response To External Stimulus Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Behavior Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Response To Lipid Regulation Of Phosphorylation Positive Regulation Of Phosphorylation Response To Stress Positive Chemotaxis Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Chemotaxis Interaction With Symbiont Regulation Of Growth Positive Regulation Of Cell Migration Regulation Of Protein Metabolic Process Regulation Of Chemotaxis Positive Regulation Of Cell Motility Secretion Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of Locomotion Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Response To Stimulus Response To Organic Substance Regulation Of Kinase Activity Positive Regulation Of Protein Kinase Activity Defense Response Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Protein Metabolic Process Killing By Host Of Symbiont Cells Positive Regulation Of Kinase Activity Positive Regulation Of Protein Modification Process Platelet Degranulation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transferase Activity Positive Regulation Of Catalytic Activity Organ Development Regulation Of Body Fluid Levels
Tagcloud ?		adaptor amplifies antagonism bdl bile binder broad chemokine conditional contributor duct elucidate exacerbated fibrogenesis fibrosis fibrotic gab1 gab1cko grb2 hepatocyte hepatocytes injections knockout ligation lipopolysaccharide liver livers myofibroblasts tetrachloride	alpha3beta1 alpha6beta4 beta4 block c2 competes coupling depends egf engagement engaging extreme her1 integrin laminin ln332 matrix migration penetrating platform qeexyx recognize sdc4 shares spreading syndecan syndecans utilized
Tagcloud (Difference) ?		adaptor amplifies antagonism bdl bile binder broad chemokine conditional contributor duct elucidate exacerbated fibrogenesis fibrosis fibrotic gab1 gab1cko grb2 hepatocyte hepatocytes injections knockout ligation lipopolysaccharide liver livers myofibroblasts tetrachloride	alpha3beta1 alpha6beta4 beta4 block c2 competes coupling depends egf engagement engaging extreme her1 integrin laminin ln332 matrix migration penetrating platform qeexyx recognize sdc4 shares spreading syndecan syndecans utilized
Tagcloud (Intersection) ?