CCL5 and PIGR

Number of citations of the paper that reports this interaction (PMID 11509627)
3

Data Source:
HPRD (in vivo)

		CCL5	PIGR
Gene Name		chemokine (C-C motif) ligand 5	polymeric immunoglobulin receptor
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex Extracellular Vesicular Exosome
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Protein Kinase Activity Protein Binding Chemokine Activity Phospholipase Activator Activity Receptor Signaling Protein Tyrosine Kinase Activator Activity CCR1 Chemokine Receptor Binding CCR4 Chemokine Receptor Binding CCR5 Chemokine Receptor Binding Chemoattractant Activity Chemokine Receptor Binding Protein Homodimerization Activity Protein Self-association Chemokine Receptor Antagonist Activity	Polymeric Immunoglobulin Receptor Activity
	Biological Process	MAPK Cascade Dendritic Cell Chemotaxis Monocyte Chemotaxis Regulation Of Chronic Inflammatory Response Protein Phosphorylation Calcium Ion Transport Cellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Leukocyte Cell-cell Adhesion G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Response To Virus Response To Toxic Substance Positive Regulation Of Activation Of JAK2 Kinase Activity Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of T Cell Chemotaxis Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Cellular Biosynthetic Process Activation Of Phospholipase D Activity Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of T Cell Proliferation Neutrophil Activation Positive Regulation Of Phosphorylation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Protein Kinase B Signaling Cellular Protein Complex Assembly Negative Regulation By Host Of Viral Transcription Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Positive Regulation Of Innate Immune Response Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Cell Adhesion Positive Regulation Of Translational Initiation Positive Regulation Of JAK-STAT Cascade Eosinophil Chemotaxis Macrophage Chemotaxis Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Regulation Of Insulin Secretion Regulation Of T Cell Activation Positive Chemotaxis Protein Tetramerization Positive Regulation Of Calcium Ion Transport Positive Regulation Of Protein Tyrosine Kinase Activity Chemokine-mediated Signaling Pathway Negative Regulation Of Chemokine-mediated Signaling Pathway Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of T Cell Apoptotic Process Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Organic Cyclic Compound Positive Regulation Of Monocyte Chemotaxis Regulation Of Neuron Death Negative Regulation Of Macrophage Apoptotic Process Positive Regulation Of T Cell Migration Positive Regulation Of Natural Killer Cell Chemotaxis	Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste Retina Homeostasis Immunoglobulin Transcytosis In Epithelial Cells Mediated By Polymeric Immunoglobulin Receptor Epidermal Growth Factor Receptor Signaling Pathway Fc Receptor Signaling Pathway Receptor Clustering
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Heparin Disaccharide I-S Heparin Disaccharide Iii-S
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		21 interactors: ACKR1 ACKR2 ACKR4 CCR1 CCR3 CCR4 CCR5 CXCL8 DPP4 EDC4 GRB2 IGFBP7 PF4 PIGR RANGAP1 RELA SDC1 SDC4 SLC2A5 TRIP6 VCAN	4 interactors: AP1M1 CCL5 CD79A RAB3B
Entrez ID		6352	5284
HPRD ID		01751	01436
Ensembl ID		ENSG00000161570	ENSG00000162896
Uniprot IDs		D0EI67 P13501	P01833
PDB IDs		1B3A 1EQT 1HRJ 1RTN 1RTO 1U4L 1U4M 1U4P 1U4R 2L9H 2VXW	1XED 2OCW 3CHN 3CM9
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Inflammatory Response Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Response To Cytokine Cellular Response To Organic Substance Chemotaxis Response To Organic Substance Locomotion Defense Response Response To External Stimulus Immune Response Cellular Response To Stimulus Response To Stimulus Signal Transduction G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Cell Migration Immune System Process Cell Motility Signaling Cell Communication Response To Stress Leukocyte Migration Positive Regulation Of Organelle Assembly Leukocyte Chemotaxis Positive Regulation Of Chemotaxis Positive Regulation Of Extracellular Vesicular Exosome Assembly Positive Regulation Of Behavior Response To Lipid Regulation Of Chemotaxis Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Regulation Of Extracellular Vesicular Exosome Assembly Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Locomotion Cell Chemotaxis Cellular Defense Response Glycosaminoglycan Catabolic Process Cytosolic Calcium Ion Homeostasis Chondroitin Sulfate Metabolic Process Regulation Of Behavior Movement Of Cell Or Subcellular Component Response To Abiotic Stimulus Positive Regulation Of Leukocyte Chemotaxis Pathogenesis Response To Radiation Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Response To Bacterium	Immune System Process Regulation Of Vesicle Size Positive Regulation Of Ion Transport Peptidyl-cysteine Methylation Negative Regulation Of Macrophage Apoptotic Process Regulation Of Immune System Process Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Natural Killer Cell Chemotaxis Negative Regulation Of Chemokine-mediated Signaling Pathway Antigen Processing And Presentation Vesicle-mediated Transport Positive Regulation Of Activation Of JAK2 Kinase Activity Positive Regulation Of Activation Of Janus Kinase Activity Exocytosis Positive Regulation Of Macrophage Chemotaxis Pigment Granule Maturation Endosome To Melanosome Transport Eosinophil Chemotaxis Eosinophil Migration Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of T Cell Chemotaxis Regulation Of Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Synaptic Transmission, Dopaminergic Cellular Pigment Accumulation Negative Regulation By Host Of Viral Transcription Positive Regulation Of Monocyte Chemotaxis Regulation Of Chronic Inflammatory Response Establishment Of Localization In Cell Regulation Of Macrophage Chemotaxis Regulation Of Monocyte Chemotaxis Positive Regulation Of Translational Initiation Dendritic Cell Chemotaxis Leukocyte Activation Activation Of Phospholipase D Activity Regulation Of Neurotransmitter Uptake Positive Regulation Of T Cell Apoptotic Process Monocyte Chemotaxis Regulation Of Macrophage Apoptotic Process Secretion By Cell Positive Regulation Of Cell Adhesion Mediated By Integrin Macrophage Chemotaxis Extracellular Negative Regulation Of Signal Transduction Positive Regulation Of T Cell Migration Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Myeloid Cell Apoptotic Process Positive Regulation Of Lymphocyte Apoptotic Process Regulation Of T Cell Migration Negative Regulation Of Viral Transcription Melanosome Organization
Tagcloud ?		adaptor amplifies antagonism bdl bile binder broad chemokine conditional contributor duct elucidate exacerbated fibrogenesis fibrosis fibrotic gab1 gab1cko grb2 hepatocyte hepatocytes injections knockout ligation lipopolysaccharide liver livers myofibroblasts tetrachloride	adenoids belonging defense degranulation destructive dimers eosinophils extravasation glandular helper iga ige immunopathology leukocytes migrate mucosa penetrating perhaps piga polymers priming reaches secretions secretory th2 tonsils transported unsuccessful
Tagcloud (Difference) ?		adaptor amplifies antagonism bdl bile binder broad chemokine conditional contributor duct elucidate exacerbated fibrogenesis fibrosis fibrotic gab1 gab1cko grb2 hepatocyte hepatocytes injections knockout ligation lipopolysaccharide liver livers myofibroblasts tetrachloride	adenoids belonging defense degranulation destructive dimers eosinophils extravasation glandular helper iga ige immunopathology leukocytes migrate mucosa penetrating perhaps piga polymers priming reaches secretions secretory th2 tonsils transported unsuccessful
Tagcloud (Intersection) ?