NLGN1 and NRXN2

Number of citations of the paper that reports this interaction (PMID 8576240)
94

Data Source:
BioGRID (pull down)

		NLGN1	NRXN2
Gene Name		neuroligin 1	neurexin 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Dendrite Filopodium Tip Synapse Postsynaptic Membrane Excitatory Synapse Neuronal Postsynaptic Density	Integral Component Of Membrane
	Molecular Function	Receptor Activity PDZ Domain Binding Neurexin Family Protein Binding Protein Dimerization Activity Cell Adhesion Molecule Binding Carboxylic Ester Hydrolase Activity	Calcium Channel Regulator Activity Metal Ion Binding Cell Adhesion Molecule Binding Neuroligin Family Protein Binding
	Biological Process	Regulation Of Respiratory Gaseous Exchange By Neurological System Process Protein Targeting Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Neuron Cell-cell Adhesion Nervous System Development Synapse Assembly Metabolic Process Positive Regulation Of Circadian Sleep/wake Cycle, Wakefulness Synaptic Vesicle Targeting Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Neuronal Signal Transduction Positive Regulation Of Synaptic Transmission, GABAergic Protein Localization To Synapse Establishment Of Protein Localization Regulation Of Neuron Differentiation Cytoskeletal Matrix Organization At Active Zone Regulation Of Synaptic Transmission Protein Homooligomerization Protein Heterotetramerization Positive Regulation Of Filopodium Assembly Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Dendritic Spine Development Terminal Button Organization Synaptic Vesicle Clustering Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering N-methyl-D-aspartate Receptor Clustering Neurexin Clustering Postsynaptic Density Protein 95 Clustering Receptor Localization To Synapse Positive Regulation Of Ruffle Assembly Positive Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Synaptic Vesicle Exocytosis Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Positive Regulation Of Excitatory Postsynaptic Membrane Potential	Neuron Cell-cell Adhesion Synaptic Transmission Neurotransmitter Secretion Synapse Assembly Adult Behavior Social Behavior Vocal Learning Vocalization Behavior Postsynaptic Membrane Assembly Gephyrin Clustering Neuroligin Clustering Postsynaptic Density Protein 95 Clustering
Pathways
Drugs
Diseases
GWAS		Major depressive disorder ( 20516156)	Urate levels ( 21768215 23263486)
Protein-Protein Interactions		6 interactors: DLG2 DLG3 DLG4 NRXN1 NRXN2 NRXN3	9 interactors: CASK DDX24 INADL MACF1 MAPK6 MLLT4 NLGN1 NLGN2 NLGN3
Entrez ID		22871	9379
HPRD ID		07195	11859
Ensembl ID		ENSG00000169760	ENSG00000110076
Uniprot IDs		D2X2H5 Q8N2Q7	G5E9G7 P58401 Q9P2S2
PDB IDs
Enriched GO Terms of Interacting Partners?		Receptor Localization To Synapse Vocalization Behavior Protein Localization To Synapse Social Behavior Synaptic Transmission Receptor Clustering Synapse Assembly Neuron Cell-cell Adhesion Cell-cell Signaling Protein Localization To Membrane Learning Postsynaptic Membrane Organization Synapse Organization Neuroligin Clustering Gephyrin Clustering Learning Or Memory Nucleotide Phosphorylation Cognition Membrane Organization Vocal Learning Regulation Of Grooming Behavior Postsynaptic Membrane Assembly Nervous System Development Axon Guidance Cellular Localization Postsynaptic Density Protein 95 Clustering Neurological System Process Neurotransmitter Secretion Single-organism Behavior Auditory Behavior Secretion By Cell Cellular Protein Localization Axonogenesis Positive Regulation Of Synapse Maturation Regulation Of Neurotransmitter Levels Axon Development Cell Morphogenesis Involved In Neuron Differentiation Behavior Chemotaxis Regulation Of Synapse Maturation Neurotransmitter Transport Adult Behavior Secretion Mechanosensory Behavior Neuron Projection Morphogenesis Response To Auditory Stimulus Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Membrane Assembly Cell Morphogenesis Involved In Differentiation Membrane Biogenesis	Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Presynaptic Membrane Organization Regulation Of Respiratory Gaseous Exchange By Neurological System Process Neuron Cell-cell Adhesion Regulation Of Respiratory System Process Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Membrane Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Respiratory Gaseous Exchange Membrane Biogenesis Postsynaptic Membrane Organization Positive Regulation Of Synapse Assembly Positive Regulation Of Excitatory Postsynaptic Membrane Potential Terminal Button Organization Positive Regulation Of Membrane Potential Regulation Of Synapse Assembly Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Synapse Assembly Regulation Of Synapse Organization Regulation Of Synapse Structure Or Activity Postsynaptic Density Protein 95 Clustering Positive Regulation Of Synaptic Transmission Membrane Depolarization Regulation Of Receptor Activity Regulation Of Inhibitory Postsynaptic Membrane Potential Regulation Of Ion Transmembrane Transport Positive Regulation Of Synaptic Transmission, GABAergic Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Protein Localization To Synapse Synapse Organization Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Cell Adhesion Regulation Of Ion Transport Cell-cell Junction Organization Regulation Of Synaptic Transmission, GABAergic Membrane Hyperpolarization Regulation Of Membrane Potential Regulation Of Dendritic Spine Development Regulation Of Synaptic Transmission Positive Regulation Of Cellular Component Biogenesis Membrane Organization Cell-cell Signaling Protein Localization To Membrane Cellular Component Assembly Regulation Of Neuron Projection Development Positive Regulation Of Ion Transmembrane Transport
Tagcloud ?		agt ass1 beadchip benjamini crym differentiates egr2 folr3 gja1 hochberg hrasls humanref illumina leiomyosarcoma lms lmss masp1 nlgn4x ostn rorb shmt1 slitrk4 tdo2 thbs1 tnnt1 tspan10 tspan7 uterine xrn2	a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn1 nrxn3 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Difference) ?		agt ass1 beadchip benjamini crym differentiates egr2 folr3 gja1 hochberg hrasls humanref illumina leiomyosarcoma lms lmss masp1 nlgn4x ostn rorb shmt1 slitrk4 tdo2 thbs1 tnnt1 tspan10 tspan7 uterine xrn2	a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn1 nrxn3 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Intersection) ?