NLGN1 and NRXN3

Number of citations of the paper that reports this interaction (PMID 8576240)
94

Data Source:
BioGRID (pull down)

		NLGN1	NRXN3
Gene Name		neuroligin 1	neurexin 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Dendrite Filopodium Tip Synapse Postsynaptic Membrane Excitatory Synapse Neuronal Postsynaptic Density	Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Receptor Activity PDZ Domain Binding Neurexin Family Protein Binding Protein Dimerization Activity Cell Adhesion Molecule Binding Carboxylic Ester Hydrolase Activity	Receptor Activity Calcium Channel Regulator Activity Metal Ion Binding Cell Adhesion Molecule Binding Neuroligin Family Protein Binding
	Biological Process	Regulation Of Respiratory Gaseous Exchange By Neurological System Process Protein Targeting Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Neuron Cell-cell Adhesion Nervous System Development Synapse Assembly Metabolic Process Positive Regulation Of Circadian Sleep/wake Cycle, Wakefulness Synaptic Vesicle Targeting Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Neuronal Signal Transduction Positive Regulation Of Synaptic Transmission, GABAergic Protein Localization To Synapse Establishment Of Protein Localization Regulation Of Neuron Differentiation Cytoskeletal Matrix Organization At Active Zone Regulation Of Synaptic Transmission Protein Homooligomerization Protein Heterotetramerization Positive Regulation Of Filopodium Assembly Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Dendritic Spine Development Terminal Button Organization Synaptic Vesicle Clustering Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering N-methyl-D-aspartate Receptor Clustering Neurexin Clustering Postsynaptic Density Protein 95 Clustering Receptor Localization To Synapse Positive Regulation Of Ruffle Assembly Positive Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Synaptic Vesicle Exocytosis Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Positive Regulation Of Excitatory Postsynaptic Membrane Potential	Angiogenesis Neuron Cell-cell Adhesion Synaptic Transmission Neurotransmitter Secretion Axon Guidance Synapse Assembly Learning Adult Behavior Social Behavior Positive Regulation Of Synapse Assembly Vocalization Behavior Positive Regulation Of Synapse Maturation
Pathways
Drugs
Diseases
GWAS		Major depressive disorder ( 20516156)	Amyotrophic lateral sclerosis (age of onset) ( 22959728) Body mass index ( 20935630) Obesity ( 23563607 21552555) Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573) Waist circumference ( 19557197)
Protein-Protein Interactions		6 interactors: DLG2 DLG3 DLG4 NRXN1 NRXN2 NRXN3	5 interactors: CASK MLLT4 NLGN1 NLGN2 NLGN3
Entrez ID		22871	9369
HPRD ID		07195	08989
Ensembl ID		ENSG00000169760
Uniprot IDs		D2X2H5 Q8N2Q7	Q9HDB5 Q9Y4C0
PDB IDs
Enriched GO Terms of Interacting Partners?		Receptor Localization To Synapse Vocalization Behavior Protein Localization To Synapse Social Behavior Synaptic Transmission Receptor Clustering Synapse Assembly Neuron Cell-cell Adhesion Cell-cell Signaling Protein Localization To Membrane Learning Postsynaptic Membrane Organization Synapse Organization Neuroligin Clustering Gephyrin Clustering Learning Or Memory Nucleotide Phosphorylation Cognition Membrane Organization Vocal Learning Regulation Of Grooming Behavior Postsynaptic Membrane Assembly Nervous System Development Axon Guidance Cellular Localization Postsynaptic Density Protein 95 Clustering Neurological System Process Neurotransmitter Secretion Single-organism Behavior Auditory Behavior Secretion By Cell Cellular Protein Localization Axonogenesis Positive Regulation Of Synapse Maturation Regulation Of Neurotransmitter Levels Axon Development Cell Morphogenesis Involved In Neuron Differentiation Behavior Chemotaxis Regulation Of Synapse Maturation Neurotransmitter Transport Adult Behavior Secretion Mechanosensory Behavior Neuron Projection Morphogenesis Response To Auditory Stimulus Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Membrane Assembly Cell Morphogenesis Involved In Differentiation Membrane Biogenesis	Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Presynaptic Membrane Organization Regulation Of Respiratory Gaseous Exchange By Neurological System Process Neuron Cell-cell Adhesion Regulation Of Respiratory System Process Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Membrane Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Respiratory Gaseous Exchange Membrane Biogenesis Postsynaptic Membrane Organization Positive Regulation Of Synapse Assembly Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Membrane Potential Terminal Button Organization Regulation Of Synapse Assembly Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Cell Adhesion Synapse Assembly Regulation Of Ion Transmembrane Transport Regulation Of Synapse Organization Regulation Of Synapse Structure Or Activity Positive Regulation Of Synaptic Transmission Membrane Depolarization Regulation Of Receptor Activity Postsynaptic Density Protein 95 Clustering Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Ion Transport Regulation Of Inhibitory Postsynaptic Membrane Potential Synapse Organization Positive Regulation Of Synaptic Transmission, GABAergic Protein Localization To Synapse Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Cell-cell Signaling Regulation Of Membrane Potential Regulation Of Synaptic Transmission Regulation Of Synaptic Transmission, GABAergic Membrane Hyperpolarization Positive Regulation Of Cellular Component Biogenesis Regulation Of Dendritic Spine Development Positive Regulation Of Ion Transmembrane Transport Single Organismal Cell-cell Adhesion Synaptic Transmission Regulation Of Dendrite Development Cellular Component Assembly Cytoskeletal Matrix Organization At Active Zone
Tagcloud ?		agt ass1 beadchip benjamini crym differentiates egr2 folr3 gja1 hochberg hrasls humanref illumina leiomyosarcoma lms lmss masp1 nlgn4x ostn rorb shmt1 slitrk4 tdo2 thbs1 tnnt1 tspan10 tspan7 uterine xrn2	a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn1 nrxn2 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Difference) ?		agt ass1 beadchip benjamini crym differentiates egr2 folr3 gja1 hochberg hrasls humanref illumina leiomyosarcoma lms lmss masp1 nlgn4x ostn rorb shmt1 slitrk4 tdo2 thbs1 tnnt1 tspan10 tspan7 uterine xrn2	a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn1 nrxn2 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Intersection) ?