NLGN1 and DLG4

Number of citations of the paper that reports this interaction (PMID 9278515)
105

Data Source:
HPRD (in vitro, two hybrid)

		NLGN1	DLG4
Gene Name		neuroligin 1	discs, large homolog 4 (Drosophila)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Dendrite Filopodium Tip Synapse Postsynaptic Membrane Excitatory Synapse Neuronal Postsynaptic Density	Cytoplasm Endoplasmic Reticulum Plasma Membrane Synaptic Vesicle Voltage-gated Potassium Channel Complex Ionotropic Glutamate Receptor Complex Postsynaptic Density Basolateral Plasma Membrane Cell Junction Endocytic Vesicle Membrane Cortical Cytoskeleton Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Selective Glutamate Receptor Complex Dendrite Cytoplasm Dendritic Spine Juxtaparanode Region Of Axon Cerebellar Mossy Fiber Neuron Projection Terminus Neuron Spine Synapse Postsynaptic Membrane Excitatory Synapse Neuronal Postsynaptic Density
	Molecular Function	Receptor Activity PDZ Domain Binding Neurexin Family Protein Binding Protein Dimerization Activity Cell Adhesion Molecule Binding Carboxylic Ester Hydrolase Activity	Guanylate Kinase Activity Protein Binding Protein C-terminus Binding Protein Phosphatase Binding PDZ Domain Binding Beta-1 Adrenergic Receptor Binding D1 Dopamine Receptor Binding P2Y1 Nucleotide Receptor Binding Protein Complex Binding Acetylcholine Receptor Binding Ionotropic Glutamate Receptor Binding Scaffold Protein Binding
	Biological Process	Regulation Of Respiratory Gaseous Exchange By Neurological System Process Protein Targeting Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Neuron Cell-cell Adhesion Nervous System Development Synapse Assembly Metabolic Process Positive Regulation Of Circadian Sleep/wake Cycle, Wakefulness Synaptic Vesicle Targeting Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Neuronal Signal Transduction Positive Regulation Of Synaptic Transmission, GABAergic Protein Localization To Synapse Establishment Of Protein Localization Regulation Of Neuron Differentiation Cytoskeletal Matrix Organization At Active Zone Regulation Of Synaptic Transmission Protein Homooligomerization Protein Heterotetramerization Positive Regulation Of Filopodium Assembly Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Dendritic Spine Development Terminal Button Organization Synaptic Vesicle Clustering Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering N-methyl-D-aspartate Receptor Clustering Neurexin Clustering Postsynaptic Density Protein 95 Clustering Receptor Localization To Synapse Positive Regulation Of Ruffle Assembly Positive Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Synaptic Vesicle Exocytosis Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Positive Regulation Of Excitatory Postsynaptic Membrane Potential	Negative Regulation Of Receptor Internalization Protein Complex Assembly Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Synaptic Transmission Nervous System Development Axon Guidance Learning Synaptic Vesicle Maturation Social Behavior Protein Localization To Synapse Locomotory Exploration Behavior Establishment Of Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Nucleotide Phosphorylation Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Synaptic Transmission Neuromuscular Process Controlling Balance Dendritic Spine Morphogenesis Vocalization Behavior Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Receptor Localization To Synapse Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Grooming Behavior
Pathways			Axon guidance L1CAM interactions Activation of Kainate Receptors upon glutamate binding CREB phosphorylation through the activation of Ras Trafficking of AMPA receptors Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII NrCAM interactions Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Activation of Ca-permeable Kainate Receptor Unblocking of NMDA receptor, glutamate binding and activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ionotropic activity of Kainate Receptors Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Major depressive disorder ( 20516156)	Liver enzyme levels (alkaline phosphatase) ( 22001757)
Protein-Protein Interactions		6 interactors: DLG2 DLG3 DLG4 NRXN1 NRXN2 NRXN3	104 interactors: ACTN2 ADRB1 AKAP5 ARHGAP32 ASIC3 ATP2B2 ATP2B4 BAI1 BEGAIN CACNG2 CASK CD46 CIT CNKSR2 CRIPT DLG2 DLG3 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DYNLL1 EFNB2 ERBB2 ERBB2IP ERBB4 EXOC4 FYN FZD1 FZD2 FZD4 FZD7 GDA GLS2 GNG13 GRASP GRIK1 GRIK2 GRIK5 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GRIN3A GRIN3B GUCY1A2 HGS HTR2A HTR2C HTT IL13RA1 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCND2 KCNJ10 KCNJ12 KCNJ2 KCNJ4 KHDRBS1 KIF13B KIF1B LIN7A LIN7B LPHN1 LRFN1 LRP1 LRP2 LRP8 LRRC1 LYN MAP1A MAP3K10 MAPK12 MDM2 NCKIPSD NDOR1 NLGN1 NLGN2 NLGN3 NLGN4X NOS1 PCDH10 PRKCA PTK2B PTPRG SCN5A SEMA4B SEMA4C SEMA4F SEMA4G SHANK1 SHANK2 SIPA1L1 SPRR2A SRC SYNGAP1 TANC1 WNT3A YES1 ZDHHC17
Entrez ID		22871	1742
HPRD ID		07195	04199
Ensembl ID		ENSG00000169760	ENSG00000132535
Uniprot IDs		D2X2H5 Q8N2Q7	B7Z647 B9EGL1 P78352
PDB IDs			1KEF 3I4W 3K82 3ZRT
Enriched GO Terms of Interacting Partners?		Receptor Localization To Synapse Vocalization Behavior Protein Localization To Synapse Social Behavior Synaptic Transmission Receptor Clustering Synapse Assembly Neuron Cell-cell Adhesion Cell-cell Signaling Protein Localization To Membrane Learning Postsynaptic Membrane Organization Synapse Organization Neuroligin Clustering Gephyrin Clustering Learning Or Memory Nucleotide Phosphorylation Cognition Membrane Organization Vocal Learning Regulation Of Grooming Behavior Postsynaptic Membrane Assembly Nervous System Development Axon Guidance Cellular Localization Postsynaptic Density Protein 95 Clustering Neurological System Process Neurotransmitter Secretion Single-organism Behavior Auditory Behavior Secretion By Cell Cellular Protein Localization Axonogenesis Positive Regulation Of Synapse Maturation Regulation Of Neurotransmitter Levels Axon Development Cell Morphogenesis Involved In Neuron Differentiation Behavior Chemotaxis Regulation Of Synapse Maturation Neurotransmitter Transport Adult Behavior Secretion Mechanosensory Behavior Neuron Projection Morphogenesis Response To Auditory Stimulus Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Membrane Assembly Cell Morphogenesis Involved In Differentiation Membrane Biogenesis	Cell-cell Signaling Synaptic Transmission Signaling Cell Communication Regulation Of Membrane Potential Regulation Of Ion Transport Regulation Of Ion Transmembrane Transport Membrane Depolarization Nervous System Development Regulation Of Postsynaptic Membrane Potential Regulation Of Signaling Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Synaptic Transmission Regulation Of Excitatory Postsynaptic Membrane Potential Neurological System Process Neuron-neuron Synaptic Transmission Glutamate Receptor Signaling Pathway Signal Transduction Metal Ion Transport Synaptic Transmission, Glutamatergic Neurogenesis Response To Stimulus Ion Transport Generation Of Neurons Cellular Response To Stimulus Transport System Development Cation Transport Cell Surface Receptor Signaling Pathway Single-organism Behavior Sensory Perception Of Pain Behavior Neuron Differentiation Regulation Of Signal Transduction Response To Abiotic Stimulus Ion Transmembrane Transport Regulation Of Cellular Localization Anatomical Structure Development Regulation Of Cellular Process Membrane Hyperpolarization Cell Differentiation Cation Transmembrane Transport Multicellular Organismal Development Developmental Process Regulation Of Phosphorus Metabolic Process Learning Response To External Stimulus Cellular Process Neuron Development Positive Regulation Of Signal Transduction
Tagcloud ?		agt ass1 beadchip benjamini crym differentiates egr2 folr3 gja1 hochberg hrasls humanref illumina leiomyosarcoma lms lmss masp1 nlgn4x ostn rorb shmt1 slitrk4 tdo2 thbs1 tnnt1 tspan10 tspan7 uterine xrn2	6g1 alleviated amyloid ca1 counteract densities distant fibrillar immunohistochemically immunotherapy oligomer oligomeric oligomers plaque plaques presynapses psd95 quantified reservoirs sequestering suffices synapse synapses synapsin synaptotoxic tg2576 unchanged unspecific vicinity
Tagcloud (Difference) ?		agt ass1 beadchip benjamini crym differentiates egr2 folr3 gja1 hochberg hrasls humanref illumina leiomyosarcoma lms lmss masp1 nlgn4x ostn rorb shmt1 slitrk4 tdo2 thbs1 tnnt1 tspan10 tspan7 uterine xrn2	6g1 alleviated amyloid ca1 counteract densities distant fibrillar immunohistochemically immunotherapy oligomer oligomeric oligomers plaque plaques presynapses psd95 quantified reservoirs sequestering suffices synapse synapses synapsin synaptotoxic tg2576 unchanged unspecific vicinity
Tagcloud (Intersection) ?