NLGN1

Gene Name		neuroligin 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Dendrite Filopodium Tip Synapse Postsynaptic Membrane Excitatory Synapse Neuronal Postsynaptic Density
	Molecular Function	Receptor Activity PDZ Domain Binding Neurexin Family Protein Binding Protein Dimerization Activity Cell Adhesion Molecule Binding Carboxylic Ester Hydrolase Activity
	Biological Process	Regulation Of Respiratory Gaseous Exchange By Neurological System Process Protein Targeting Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Neuron Cell-cell Adhesion Nervous System Development Synapse Assembly Metabolic Process Positive Regulation Of Circadian Sleep/wake Cycle, Wakefulness Synaptic Vesicle Targeting Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Neuronal Signal Transduction Positive Regulation Of Synaptic Transmission, GABAergic Protein Localization To Synapse Establishment Of Protein Localization Regulation Of Neuron Differentiation Cytoskeletal Matrix Organization At Active Zone Regulation Of Synaptic Transmission Protein Homooligomerization Protein Heterotetramerization Positive Regulation Of Filopodium Assembly Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Dendritic Spine Development Terminal Button Organization Synaptic Vesicle Clustering Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering N-methyl-D-aspartate Receptor Clustering Neurexin Clustering Postsynaptic Density Protein 95 Clustering Receptor Localization To Synapse Positive Regulation Of Ruffle Assembly Positive Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Synaptic Vesicle Exocytosis Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Positive Regulation Of Excitatory Postsynaptic Membrane Potential
Pathways
Drugs
Diseases
GWAS		Major depressive disorder ( 20516156)
Protein-protein Interactions		6 interactors: DLG2 DLG3 DLG4 NRXN1 NRXN2 NRXN3
Entrez ID		22871
HPRD ID		07195
Ensembl ID		ENSG00000169760
Uniprot IDs		D2X2H5 Q8N2Q7
PDB IDs
Enriched GO Terms of Interacting Partners?		Receptor Localization To Synapse Vocalization Behavior Protein Localization To Synapse Social Behavior Synaptic Transmission Receptor Clustering Synapse Assembly Neuron Cell-cell Adhesion Cell-cell Signaling Protein Localization To Membrane Learning Postsynaptic Membrane Organization Synapse Organization Neuroligin Clustering Gephyrin Clustering Learning Or Memory Nucleotide Phosphorylation Cognition Membrane Organization Vocal Learning Regulation Of Grooming Behavior Postsynaptic Membrane Assembly Nervous System Development Axon Guidance Cellular Localization Postsynaptic Density Protein 95 Clustering Neurological System Process Neurotransmitter Secretion Single-organism Behavior Auditory Behavior Secretion By Cell Cellular Protein Localization Axonogenesis Positive Regulation Of Synapse Maturation Regulation Of Neurotransmitter Levels Axon Development Cell Morphogenesis Involved In Neuron Differentiation Behavior Chemotaxis Regulation Of Synapse Maturation Neurotransmitter Transport Adult Behavior Secretion Mechanosensory Behavior Neuron Projection Morphogenesis Response To Auditory Stimulus Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Membrane Assembly Cell Morphogenesis Involved In Differentiation Membrane Biogenesis
Tagcloud ?		agt ass1 beadchip benjamini crym differentiates egr2 folr3 gja1 hochberg hrasls humanref illumina leiomyosarcoma lms lmss masp1 nlgn4x ostn rorb shmt1 slitrk4 tdo2 thbs1 tnnt1 tspan10 tspan7 uterine xrn2