FCN1 and ELN

Number of citations of the paper that reports this interaction (PMID 8947836)
6

Data Source:
HPRD (in vitro)

		FCN1	ELN
Gene Name		ficolin (collagen/fibrinogen domain containing) 1	elastin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Trimer Extrinsic Component Of External Side Of Plasma Membrane	Extracellular Region Proteinaceous Extracellular Matrix Elastic Fiber
	Molecular Function	G-protein Coupled Receptor Binding Protein Binding Signaling Pattern Recognition Receptor Activity Carbohydrate Binding Sialic Acid Binding Metal Ion Binding	Extracellular Matrix Structural Constituent Protein Binding
	Biological Process	Complement Activation, Lectin Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Complement Activation G-protein Coupled Receptor Signaling Pathway Protein Localization To Cell Surface Recognition Of Apoptotic Cell Innate Immune Response Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of Interleukin-8 Secretion	Respiratory Gaseous Exchange Blood Circulation Cell Proliferation Organ Morphogenesis Extracellular Matrix Disassembly Extracellular Matrix Organization
Pathways		Creation of C4 and C2 activators Complement cascade Ficolins bind to repetitive carbohydrate structures on the target cell surface Initial triggering of complement Lectin pathway of complement activation Innate Immune System	Molecules associated with elastic fibres Elastic fibre formation Degradation of the extracellular matrix
Drugs			Rofecoxib
Diseases
GWAS
Protein-Protein Interactions		2 interactors: ELN TGFB1	21 interactors: ASS1 BGN CKMT2 CLU DCN ELANE FBLN1 FBLN2 FBN1 FBN2 FCN1 FKBP10 LGALS3 LOX LOXL1 LYZ MAGEH1 MFAP2 NID2 PRTN3 SPINK1
Entrez ID		2219	2006
HPRD ID		03153	00556
Ensembl ID		ENSG00000085265	ENSG00000049540
Uniprot IDs		O00602	B3KRT8 B4E3S4 E7EN65 E7ENM0 G3V0G6 G5E950 P15502 Q59H17 Q6ZUN2 Q8NBI4
PDB IDs		2D39 2JHH 2JHI 2JHK 2JHL 2JHM 2WNP
Enriched GO Terms of Interacting Partners?		Tissue Remodeling Defense Response To Fungus, Incompatible Interaction Positive Regulation Of NAD+ ADP-ribosyltransferase Activity Active Induction Of Host Immune Response By Virus Regulation Of Protein Complex Assembly Negative Regulation Of Hyaluronan Biosynthetic Process Macrophage Derived Foam Cell Differentiation Evasion Or Tolerance Of Host Defenses By Virus Regulation Of Actin Cytoskeleton Organization Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Actin Filament-based Process Negative Regulation Of Macrophage Cytokine Production Ossification Involved In Bone Remodeling Tolerance Induction To Self Antigen Positive Regulation Of Extracellular Matrix Assembly Negative Regulation Of Extracellular Matrix Organization Negative Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Exit From Mitosis Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Regulation Of Extracellular Matrix Assembly Positive Regulation Of Smooth Muscle Cell Differentiation Frontal Suture Morphogenesis Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Mammary Gland Branching Involved In Thelarche Regulatory T Cell Differentiation Regulation Of Blood Vessel Remodeling Regulation Of Cytoskeleton Organization Common-partner SMAD Protein Phosphorylation Response To Host Immune Response Wound Healing Involved In Inflammatory Response Branch Elongation Involved In Mammary Gland Duct Branching Positive Regulation Of Isotype Switching To IgA Isotypes Tolerance Induction Positive Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Calcium Ion Transport Into Cytosol SMAD Protein Import Into Nucleus Positive Regulation Of Superoxide Anion Generation Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Interleukin-17 Production Positive Regulation Of Fibroblast Migration Regulation Of MiRNA Metabolic Process Positive Regulation Of Odontogenesis Development Of Secondary Female Sexual Characteristics Regulation Of Exit From Mitosis Negative Regulation Of Phagocytosis SMAD Protein Complex Assembly Cell Proliferation Cranial Suture Morphogenesis Hyaluronan Catabolic Process	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Sequestering Of TGFbeta In Extracellular Matrix Sequestering Of Extracellular Ligand From Receptor Response To Other Organism Response To Biotic Stimulus Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Dermatan Sulfate Biosynthetic Process Response To Bacterium Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Extracellular Negative Regulation Of Signal Transduction Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Chondroitin Sulfate Biosynthetic Process Regulation Of Calcium Ion Import Chondroitin Sulfate Proteoglycan Biosynthetic Process Positive Regulation Of Interleukin-8 Production Response To External Stimulus Positive Regulation Of Nitric Oxide Biosynthetic Process Response To Lipid Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Peptide Cross-linking Defense Response Negative Regulation Of Endocytosis Multicellular Organismal Development Argininosuccinate Metabolic Process Negative Regulation Of Immunological Synapse Formation Positive Regulation Of Tau-protein Kinase Activity Regulation Of Neuronal Signal Transduction Microglial Cell Proliferation Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Chondroitin Sulfate Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process System Development Response To Stress Chaperone-mediated Protein Folding Regulation Of Reactive Oxygen Species Biosynthetic Process Collagen Catabolic Process Wound Healing Immune System Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Neurofibrillary Tangle Assembly Protein Deamination Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Cellular Response To Amine Stimulus Neutrophil Mediated Killing Of Fungus
Tagcloud ?			additive amounts bioactive compound cosmetics curcuma curcumin detroit elastic elastin enhance extract fbn1 fibers fibrillin fibroblast food foods generally herbal longa medicine mum polyphenol promoters rhizome spice tropoelastin yellow
Tagcloud (Difference) ?			additive amounts bioactive compound cosmetics curcuma curcumin detroit elastic elastin enhance extract fbn1 fibers fibrillin fibroblast food foods generally herbal longa medicine mum polyphenol promoters rhizome spice tropoelastin yellow
Tagcloud (Intersection) ?