ELN and BGN

Number of citations of the paper that reports this interaction (PMID 11723132)
25

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		ELN	BGN
Gene Name		elastin	biglycan
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Elastic Fiber	Extracellular Region Proteinaceous Extracellular Matrix Golgi Lumen Cell Surface Transport Vesicle Extracellular Matrix Sarcolemma Lysosomal Lumen Extracellular Vesicular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding	Extracellular Matrix Structural Constituent Glycosaminoglycan Binding Extracellular Matrix Binding
	Biological Process	Respiratory Gaseous Exchange Blood Circulation Cell Proliferation Organ Morphogenesis Extracellular Matrix Disassembly Extracellular Matrix Organization	Blood Vessel Remodeling Carbohydrate Metabolic Process Biological_process Pathogenesis Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Small Molecule Metabolic Process
Pathways		Molecules associated with elastic fibres Elastic fibre formation Degradation of the extracellular matrix	MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Heparan sulfate/heparin (HS-GAG) metabolism Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism CS/DS degradation Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora ECM proteoglycans Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A Dermatan sulfate biosynthesis Defective CHSY1 causes TPBS MPS IV - Morquio syndrome B MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome
Drugs		Rofecoxib
Diseases
GWAS
Protein-Protein Interactions		21 interactors: ASS1 BGN CKMT2 CLU DCN ELANE FBLN1 FBLN2 FBN1 FBN2 FCN1 FKBP10 LGALS3 LOX LOXL1 LYZ MAGEH1 MFAP2 NID2 PRTN3 SPINK1	16 interactors: APOB APP BMP4 COL1A1 COL1A2 COL2A1 COL4A2 DAG1 ELN HDL3 JPH3 MFAP2 PLA2G1B TGFB1 TNF WISP1
Entrez ID		2006	633
HPRD ID		00556	02359
Ensembl ID		ENSG00000049540	ENSG00000182492
Uniprot IDs		B3KRT8 B4E3S4 E7EN65 E7ENM0 G3V0G6 G5E950 P15502 Q59H17 Q6ZUN2 Q8NBI4	B4DNL4 P21810 Q8NAB7
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Sequestering Of TGFbeta In Extracellular Matrix Sequestering Of Extracellular Ligand From Receptor Response To Other Organism Response To Biotic Stimulus Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Dermatan Sulfate Biosynthetic Process Response To Bacterium Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Extracellular Negative Regulation Of Signal Transduction Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Chondroitin Sulfate Biosynthetic Process Regulation Of Calcium Ion Import Chondroitin Sulfate Proteoglycan Biosynthetic Process Positive Regulation Of Interleukin-8 Production Response To External Stimulus Positive Regulation Of Nitric Oxide Biosynthetic Process Response To Lipid Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Peptide Cross-linking Defense Response Negative Regulation Of Endocytosis Multicellular Organismal Development Argininosuccinate Metabolic Process Negative Regulation Of Immunological Synapse Formation Positive Regulation Of Tau-protein Kinase Activity Regulation Of Neuronal Signal Transduction Microglial Cell Proliferation Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Chondroitin Sulfate Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process System Development Response To Stress Chaperone-mediated Protein Folding Regulation Of Reactive Oxygen Species Biosynthetic Process Collagen Catabolic Process Wound Healing Immune System Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Neurofibrillary Tangle Assembly Protein Deamination Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Cellular Response To Amine Stimulus Neutrophil Mediated Killing Of Fungus	Extracellular Matrix Organization Extracellular Structure Organization Locomotion Anatomical Structure Morphogenesis Multicellular Organismal Metabolic Process Movement Of Cell Or Subcellular Component Extracellular Matrix Disassembly Response To External Stimulus Organ Morphogenesis Protein Localization To Nucleus Collagen Catabolic Process Cell Morphogenesis Involved In Differentiation Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Leukocyte Migration System Development Response To Organic Substance Cellular Response To Organic Substance Negative Regulation Of Myoblast Differentiation Response To Hormone Cellular Response To Growth Factor Stimulus Bone Morphogenesis Chemotaxis Multicellular Organismal Development Response To Growth Factor Immune System Process Anatomical Structure Development Cell Morphogenesis Organ Development Salivary Gland Morphogenesis Endochondral Ossification Gland Morphogenesis Regulation Of Myoblast Differentiation Salivary Gland Development Negative Regulation Of Muscle Cell Differentiation Cellular Response To Acid Chemical Cellular Response To Lipid Cellular Response To Transforming Growth Factor Beta Stimulus Blood Coagulation Hemostasis Developmental Process Exocrine System Development Response To Transforming Growth Factor Beta Platelet Activation Cartilage Development Common-partner SMAD Protein Phosphorylation Cell Migration Cellular Response To Amino Acid Stimulus Collagen Fibril Organization Cardiovascular System Development
Tagcloud ?		additive amounts bioactive compound cosmetics curcuma curcumin detroit elastic elastin enhance extract fbn1 fibers fibrillin fibroblast food foods generally herbal longa medicine mum polyphenol promoters rhizome spice tropoelastin yellow	bambara bean beverage bgnm bgns boiled cow cowpea crop crops drought eaten fermented groundnut irritable legume legumes neglected nutritious probiotic probiotics relish roasted salted snack subterraenea traced verdc vigna
Tagcloud (Difference) ?		additive amounts bioactive compound cosmetics curcuma curcumin detroit elastic elastin enhance extract fbn1 fibers fibrillin fibroblast food foods generally herbal longa medicine mum polyphenol promoters rhizome spice tropoelastin yellow	bambara bean beverage bgnm bgns boiled cow cowpea crop crops drought eaten fermented groundnut irritable legume legumes neglected nutritious probiotic probiotics relish roasted salted snack subterraenea traced verdc vigna
Tagcloud (Intersection) ?