FCN1

Gene Name		ficolin (collagen/fibrinogen domain containing) 1
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Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Trimer Extrinsic Component Of External Side Of Plasma Membrane
	Molecular Function	G-protein Coupled Receptor Binding Protein Binding Signaling Pattern Recognition Receptor Activity Carbohydrate Binding Sialic Acid Binding Metal Ion Binding
	Biological Process	Complement Activation, Lectin Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Complement Activation G-protein Coupled Receptor Signaling Pathway Protein Localization To Cell Surface Recognition Of Apoptotic Cell Innate Immune Response Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of Interleukin-8 Secretion
Pathways		Creation of C4 and C2 activators Complement cascade Ficolins bind to repetitive carbohydrate structures on the target cell surface Initial triggering of complement Lectin pathway of complement activation Innate Immune System
Drugs
Diseases
GWAS
Protein-protein Interactions		2 interactors: ELN TGFB1
Entrez ID		2219
HPRD ID		03153
Ensembl ID		ENSG00000085265
Uniprot IDs		O00602
PDB IDs		2D39 2JHH 2JHI 2JHK 2JHL 2JHM 2WNP
Enriched GO Terms of Interacting Partners?		Tissue Remodeling Defense Response To Fungus, Incompatible Interaction Positive Regulation Of NAD+ ADP-ribosyltransferase Activity Active Induction Of Host Immune Response By Virus Regulation Of Protein Complex Assembly Negative Regulation Of Hyaluronan Biosynthetic Process Macrophage Derived Foam Cell Differentiation Evasion Or Tolerance Of Host Defenses By Virus Regulation Of Actin Cytoskeleton Organization Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Actin Filament-based Process Negative Regulation Of Macrophage Cytokine Production Ossification Involved In Bone Remodeling Tolerance Induction To Self Antigen Positive Regulation Of Extracellular Matrix Assembly Negative Regulation Of Extracellular Matrix Organization Negative Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Exit From Mitosis Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Regulation Of Extracellular Matrix Assembly Positive Regulation Of Smooth Muscle Cell Differentiation Frontal Suture Morphogenesis Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Mammary Gland Branching Involved In Thelarche Regulatory T Cell Differentiation Regulation Of Blood Vessel Remodeling Regulation Of Cytoskeleton Organization Common-partner SMAD Protein Phosphorylation Response To Host Immune Response Wound Healing Involved In Inflammatory Response Branch Elongation Involved In Mammary Gland Duct Branching Positive Regulation Of Isotype Switching To IgA Isotypes Tolerance Induction Positive Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Calcium Ion Transport Into Cytosol SMAD Protein Import Into Nucleus Positive Regulation Of Superoxide Anion Generation Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Interleukin-17 Production Positive Regulation Of Fibroblast Migration Regulation Of MiRNA Metabolic Process Positive Regulation Of Odontogenesis Development Of Secondary Female Sexual Characteristics Regulation Of Exit From Mitosis Negative Regulation Of Phagocytosis SMAD Protein Complex Assembly Cell Proliferation Cranial Suture Morphogenesis Hyaluronan Catabolic Process
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