ELN and PRTN3

Number of citations of the paper that reports this interaction (PMID 11867344)
2

Data Source:
HPRD (in vitro)

		ELN	PRTN3
Gene Name		elastin	proteinase 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Elastic Fiber	Extracellular Space Cytosol Plasma Membrane Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding	Serine-type Endopeptidase Activity Serine-type Peptidase Activity Enzyme Binding
	Biological Process	Respiratory Gaseous Exchange Blood Circulation Cell Proliferation Organ Morphogenesis Extracellular Matrix Disassembly Extracellular Matrix Organization	Proteolysis Blood Coagulation Positive Regulation Of Cell Proliferation Collagen Catabolic Process Negative Regulation Of Phagocytosis Mature Conventional Dendritic Cell Differentiation
Pathways		Molecules associated with elastic fibres Elastic fibre formation Degradation of the extracellular matrix	Common Pathway Formation of Fibrin Clot (Clotting Cascade)
Drugs		Rofecoxib
Diseases
GWAS
Protein-Protein Interactions		21 interactors: ASS1 BGN CKMT2 CLU DCN ELANE FBLN1 FBLN2 FBN1 FBN2 FCN1 FKBP10 LGALS3 LOX LOXL1 LYZ MAGEH1 MFAP2 NID2 PRTN3 SPINK1	13 interactors: CAMP ELN F2R F2RL1 IL1B IL32 ITGB2 RELA SERPINA1 SERPINB1 SERPINB13 SMAD3 TNF
Entrez ID		2006	5657
HPRD ID		00556	01512
Ensembl ID		ENSG00000049540	ENSG00000196415
Uniprot IDs		B3KRT8 B4E3S4 E7EN65 E7ENM0 G3V0G6 G5E950 P15502 Q59H17 Q6ZUN2 Q8NBI4	P24158
PDB IDs			1FUJ
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Sequestering Of TGFbeta In Extracellular Matrix Sequestering Of Extracellular Ligand From Receptor Response To Other Organism Response To Biotic Stimulus Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Dermatan Sulfate Biosynthetic Process Response To Bacterium Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Extracellular Negative Regulation Of Signal Transduction Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Chondroitin Sulfate Biosynthetic Process Regulation Of Calcium Ion Import Chondroitin Sulfate Proteoglycan Biosynthetic Process Positive Regulation Of Interleukin-8 Production Response To External Stimulus Positive Regulation Of Nitric Oxide Biosynthetic Process Response To Lipid Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Peptide Cross-linking Defense Response Negative Regulation Of Endocytosis Multicellular Organismal Development Argininosuccinate Metabolic Process Negative Regulation Of Immunological Synapse Formation Positive Regulation Of Tau-protein Kinase Activity Regulation Of Neuronal Signal Transduction Microglial Cell Proliferation Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Chondroitin Sulfate Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process System Development Response To Stress Chaperone-mediated Protein Folding Regulation Of Reactive Oxygen Species Biosynthetic Process Collagen Catabolic Process Wound Healing Immune System Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Neurofibrillary Tangle Assembly Protein Deamination Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Cellular Response To Amine Stimulus Neutrophil Mediated Killing Of Fungus	Response To Other Organism Inflammatory Response Response To Biotic Stimulus Positive Regulation Of Interleukin-8 Production Defense Response Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Regulation Of Protein Metabolic Process Positive Regulation Of Cytokine Production Regulation Of Proteolysis Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Positive Regulation Of Interleukin-6 Production Response To External Stimulus Immune Response Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Cellular Protein Metabolic Process Response To Bacterium Regulation Of Cytokine Production Negative Regulation Of Protein Secretion Regulation Of Interleukin-6 Production Positive Regulation Of NF-kappaB Transcription Factor Activity Leukocyte Cell-cell Adhesion Positive Regulation Of Protein Transport Cell Activation Response To Stress Positive Regulation Of Calcidiol 1-monooxygenase Activity Positive Regulation Of Vitamin D Biosynthetic Process Sequestering Of Triglyceride Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Lipopolysaccharide Positive Regulation Of Transcription Factor Import Into Nucleus Cellular Response To Molecule Of Bacterial Origin Negative Regulation Of Secretion By Cell Regulation Of Phosphorylation Negative Regulation Of Secretion Positive Regulation Of Phagocytosis Negative Regulation Of Protein Transport Response To Lipid Negative Regulation Of Cellular Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Immune Response Regulation Of Chemokine Production Negative Regulation Of Protein Metabolic Process Regulation Of Renin Secretion Into Blood Stream Immune System Process
Tagcloud ?		additive amounts bioactive compound cosmetics curcuma curcumin detroit elastic elastin enhance extract fbn1 fibers fibrillin fibroblast food foods generally herbal longa medicine mum polyphenol promoters rhizome spice tropoelastin yellow	aspartic cathepsin cited2 colonies compromised elastase elementbinding embryogenesis eosinophil fetal gata2 glutamic kit lef lethality lin lineages livers lymphoid manifesting modulator mpo notch1 peroxidase reconstitution sca transactivators uncovers wnt5a
Tagcloud (Difference) ?		additive amounts bioactive compound cosmetics curcuma curcumin detroit elastic elastin enhance extract fbn1 fibers fibrillin fibroblast food foods generally herbal longa medicine mum polyphenol promoters rhizome spice tropoelastin yellow	aspartic cathepsin cited2 colonies compromised elastase elementbinding embryogenesis eosinophil fetal gata2 glutamic kit lef lethality lin lineages livers lymphoid manifesting modulator mpo notch1 peroxidase reconstitution sca transactivators uncovers wnt5a
Tagcloud (Intersection) ?