ELK1 and ID1

Number of citations of the paper that reports this interaction (PMID 10022839)
29

Data Source:
HPRD (in vitro)

		ELK1	ID1
Gene Name		ELK1, member of ETS oncogene family	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Dendrite Neuronal Cell Body Axon Terminus	Nucleus Nucleoplasm Golgi Apparatus
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Core Promoter Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Dimerization Activity
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter Response To Light Stimulus Cell Differentiation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Innate Immune Response Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Stress-activated MAPK Cascade Cellular Response To Testosterone Stimulus Cellular Response To Gamma Radiation Positive Regulation Of Neuron Death	Negative Regulation Of Transcription From RNA Polymerase II Promoter Angiogenesis Endothelial Cell Morphogenesis Transcription, DNA-templated Transforming Growth Factor Beta Receptor Signaling Pathway Heart Development Circadian Rhythm Negative Regulation Of Transcription By Transcription Factor Localization BMP Signaling Pathway Protein Destabilization Collagen Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Regulation Of MAPK Cascade Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Blood Vessel Endothelial Cell Migration Negative Regulation Of Osteoblast Differentiation Regulation Of Angiogenesis Negative Regulation Of Transcription, DNA-templated Response To Antibiotic Blood Vessel Morphogenesis Lung Morphogenesis Lung Vasculature Development
Pathways		Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade ERK/MAPK targets Innate Immune System Signalling by NGF TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 3 (TLR3) Cascade ERK/MAPK targets Toll Like Receptor 4 (TLR4) Cascade MAPK targets/ Nuclear events mediated by MAP kinases Nuclear Events (kinase and transcription factor activation)	Cellular Senescence Oncogene Induced Senescence
Drugs
Diseases
GWAS
Protein-Protein Interactions		38 interactors: APP BRCA1 CDK6 CEBPB CREBBP EMX1 EP300 EWSR1 FBXO25 FLI1 FOS GRB10 GRB2 HDAC1 HOXB13 ID1 ID2 ID3 KLF4 MAD2L2 MAP2K1 MAP2K3 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9 MOB4 PIAS2 SNCA SRF STARD3NL STK16 TAOK2 UBC UBE2I	18 interactors: CASK COPB1 ELK1 ELK4 GATA4 HES1 IFI16 IKBKG MYF5 MYF6 MYOD1 MYOG PSMD4 RUNX1T1 SUV39H1 TCF12 TCF3 TCF4
Entrez ID		2002	3397
HPRD ID		02407	08980
Ensembl ID		ENSG00000126767	ENSG00000125968
Uniprot IDs		P19419 Q86SR6	P41134
PDB IDs		1DUX
Enriched GO Terms of Interacting Partners?		Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Stress-activated MAPK Cascade Positive Regulation Of Metabolic Process Stress-activated Protein Kinase Signaling Cascade Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Toll-like Receptor Signaling Pathway Regulation Of RNA Biosynthetic Process Cellular Response To Stress Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Macromolecule Biosynthetic Process MAPK Cascade Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Regulation Of Signaling Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Positive Regulation Of Innate Immune Response Signal Transduction By Phosphorylation Response To Growth Factor Innate Immune Response Response To Stress Immune System Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Innate Immune Response Cellular Response To Organic Substance Transcription, DNA-templated Immune Response Regulation Of Phosphorylation RNA Biosynthetic Process	Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Gene Expression Positive Regulation Of Skeletal Muscle Fiber Development Cell Fate Commitment Muscle Structure Development Muscle Cell Differentiation Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Striated Muscle Tissue Development Muscle Cell Fate Commitment Positive Regulation Of Myoblast Differentiation Positive Regulation Of Myoblast Fusion Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Striated Muscle Tissue Development Positive Regulation Of Muscle Tissue Development Regulation Of Gene Expression Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of Cell Development Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Regulation Of Myoblast Fusion Cell Differentiation Positive Regulation Of Metabolic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Myotube Differentiation Biosynthetic Process Regulation Of Myoblast Differentiation Regulation Of Metabolic Process Regulation Of Cell Development
Tagcloud ?		activate activated atf2 hearts hypertrophic ischemia jnk jun kd mapk mapkapk2 mapks mekk1 myocyte myocytes perfused reactivating reperfusion rk sapks sek1 speculate stimulates stresses subfamily superfamily transactivating transfection ventricular	accessory ae3 ae4 alphae1 alphae3 boxes counterparts deregulation differs dissect e47s endogenously enhancer enhancers exclusive heb helix hlh hpb igmicro leukemias lymphoblastic modify nih tal1 tcralpha tcralphabeta tcrdelta transactivate
Tagcloud (Difference) ?		activate activated atf2 hearts hypertrophic ischemia jnk jun kd mapk mapkapk2 mapks mekk1 myocyte myocytes perfused reactivating reperfusion rk sapks sek1 speculate stimulates stresses subfamily superfamily transactivating transfection ventricular	accessory ae3 ae4 alphae1 alphae3 boxes counterparts deregulation differs dissect e47s endogenously enhancer enhancers exclusive heb helix hlh hpb igmicro leukemias lymphoblastic modify nih tal1 tcralpha tcralphabeta tcrdelta transactivate
Tagcloud (Intersection) ?