ID1 and HES1

Number of citations of the paper that reports this interaction (PMID 11756408)
23

Data Source:
HPRD (two hybrid, in vivo)

		ID1	HES1
Gene Name		inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	hes family bHLH transcription factor 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Golgi Apparatus	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Dimerization Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Homodimerization Activity Histone Deacetylase Binding Sequence-specific DNA Binding Chaperone Binding N-box Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Angiogenesis Endothelial Cell Morphogenesis Transcription, DNA-templated Transforming Growth Factor Beta Receptor Signaling Pathway Heart Development Circadian Rhythm Negative Regulation Of Transcription By Transcription Factor Localization BMP Signaling Pathway Protein Destabilization Collagen Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Regulation Of MAPK Cascade Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Blood Vessel Endothelial Cell Migration Negative Regulation Of Osteoblast Differentiation Regulation Of Angiogenesis Negative Regulation Of Transcription, DNA-templated Response To Antibiotic Blood Vessel Morphogenesis Lung Morphogenesis Lung Vasculature Development	Negative Regulation Of Transcription From RNA Polymerase II Promoter Liver Development Embryonic Heart Tube Morphogenesis Outflow Tract Morphogenesis Regulation Of Secondary Heart Field Cardioblast Proliferation Ventricular Septum Development Transcription From RNA Polymerase II Promoter Protein Complex Assembly Cell Adhesion Notch Signaling Pathway Smoothened Signaling Pathway STAT Protein Import Into Nucleus Nervous System Development Positive Regulation Of Cell Proliferation Cell Migration Telencephalon Development Midbrain-hindbrain Boundary Morphogenesis Oculomotor Nerve Development Trochlear Nerve Development Hindbrain Morphogenesis Forebrain Radial Glial Cell Differentiation Adenohypophysis Development Lung Development Positive Regulation Of BMP Signaling Pathway Midbrain Development Endocrine Pancreas Development Somatic Stem Cell Maintenance Ascending Aorta Morphogenesis Positive Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Auditory Receptor Cell Fate Determination Positive Regulation Of DNA Binding Regulation Of Fat Cell Differentiation Negative Regulation Of Auditory Receptor Cell Differentiation Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Mitotic Cell Cycle, Embryonic Lateral Inhibition Positive Regulation Of JAK-STAT Cascade Cell Maturation Thymus Development Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Astrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Artery Morphogenesis Regulation Of Timing Of Neuron Differentiation Negative Regulation Of Glial Cell Proliferation Ventricular Septum Morphogenesis Ureteric Bud Morphogenesis Labyrinthine Layer Blood Vessel Development Common Bile Duct Development Negative Regulation Of Stomach Neuroendocrine Cell Differentiation Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Pharyngeal Arch Artery Morphogenesis Glomerulus Vasculature Development Comma-shaped Body Morphogenesis S-shaped Body Morphogenesis Renal Interstitial Fibroblast Development Metanephric Nephron Tubule Morphogenesis Cochlea Development Vascular Smooth Muscle Cell Development Neuronal Stem Cell Maintenance Negative Regulation Of Pancreatic A Cell Differentiation Negative Regulation Of Stem Cell Differentiation Negative Regulation Of Pro-B Cell Differentiation Negative Regulation Of Forebrain Neuron Differentiation
Pathways		Cellular Senescence Oncogene Induced Senescence	Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH NOTCH2 intracellular domain regulates transcription Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH2 Regulation of beta-cell development Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		18 interactors: CASK COPB1 ELK1 ELK4 GATA4 HES1 IFI16 IKBKG MYF5 MYF6 MYOD1 MYOG PSMD4 RUNX1T1 SUV39H1 TCF12 TCF3 TCF4	33 interactors: APCS APH1A ASGR2 CSNK1E FANCA FANCE FANCF FANCG FANCL FHL1 FOXG1 GAPDH HDAC6 HES6 HEY2 HMGB1 HMGCL ID1 ID2 ID3 ID4 JAK2 LTBR NR4A1 NUDT3 PRKCA PTK2 SIRT1 STAT3 TLE1 TLE2 UBQLN1 YWHAB
Entrez ID		3397	3280
HPRD ID		08980	00770
Ensembl ID		ENSG00000125968	ENSG00000114315
Uniprot IDs		P41134	Q14469
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Gene Expression Positive Regulation Of Skeletal Muscle Fiber Development Cell Fate Commitment Muscle Structure Development Muscle Cell Differentiation Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Striated Muscle Tissue Development Muscle Cell Fate Commitment Positive Regulation Of Myoblast Differentiation Positive Regulation Of Myoblast Fusion Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Striated Muscle Tissue Development Positive Regulation Of Muscle Tissue Development Regulation Of Gene Expression Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of Cell Development Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Regulation Of Myoblast Fusion Cell Differentiation Positive Regulation Of Metabolic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Myotube Differentiation Biosynthetic Process Regulation Of Myoblast Differentiation Regulation Of Metabolic Process Regulation Of Cell Development	System Development Organ Development Multicellular Organismal Development Response To Stress Anatomical Structure Development Regulation Of Cell Death Negative Regulation Of Biosynthetic Process Developmental Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Apoptotic Process Response To Stimulus Rhythmic Process Cellular Metabolic Process Cellular Response To Stimulus Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cell Differentiation Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Nitrogen Compound Metabolic Process Circadian Rhythm Regulation Of DNA Binding Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Cellular Response To Stress Negative Regulation Of Cell Differentiation Apoptotic Process Negative Regulation Of DNA Binding Regulation Of Cell Differentiation Programmed Cell Death Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Death Death Regulation Of Osteoblast Differentiation Positive Regulation Of Apoptotic Process DNA Repair Response To Growth Factor Anatomical Structure Morphogenesis Regulation Of Cell Proliferation Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Response To External Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Negative Regulation Of Cell Death
Tagcloud ?		accessory ae3 ae4 alphae1 alphae3 boxes counterparts deregulation differs dissect e47s endogenously enhancer enhancers exclusive heb helix hlh hpb igmicro leukemias lymphoblastic modify nih tal1 tcralpha tcralphabeta tcrdelta transactivate	alterations anatomic astrocytoma astrocytomas biology braf grade hey1 hey2 implicated inhibiting interference much needed neoplastic notch notch1 notch2 overexpressed pa pas pediatric pilocytic res186 res259 secretase tumorigenesis variable viable
Tagcloud (Difference) ?		accessory ae3 ae4 alphae1 alphae3 boxes counterparts deregulation differs dissect e47s endogenously enhancer enhancers exclusive heb helix hlh hpb igmicro leukemias lymphoblastic modify nih tal1 tcralpha tcralphabeta tcrdelta transactivate	alterations anatomic astrocytoma astrocytomas biology braf grade hey1 hey2 implicated inhibiting interference much needed neoplastic notch notch1 notch2 overexpressed pa pas pediatric pilocytic res186 res259 secretase tumorigenesis variable viable
Tagcloud (Intersection) ?