ELK1 and STK16

Number of citations of the paper that reports this interaction (PMID 10947953)
2

Data Source:
HPRD (in vitro, in vivo)

		ELK1	STK16
Gene Name		ELK1, member of ETS oncogene family	serine/threonine kinase 16
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Dendrite Neuronal Cell Body Axon Terminus	Cytoplasm Golgi-associated Vesicle Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Core Promoter Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Protein Serine/threonine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter Response To Light Stimulus Cell Differentiation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Innate Immune Response Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Stress-activated MAPK Cascade Cellular Response To Testosterone Stimulus Cellular Response To Gamma Radiation Positive Regulation Of Neuron Death	Regulation Of Signal Transduction Peptidyl-tyrosine Phosphorylation Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Autophosphorylation Cellular Response To Transforming Growth Factor Beta Stimulus
Pathways		Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade ERK/MAPK targets Innate Immune System Signalling by NGF TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 3 (TLR3) Cascade ERK/MAPK targets Toll Like Receptor 4 (TLR4) Cascade MAPK targets/ Nuclear events mediated by MAP kinases Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS
Protein-Protein Interactions		38 interactors: APP BRCA1 CDK6 CEBPB CREBBP EMX1 EP300 EWSR1 FBXO25 FLI1 FOS GRB10 GRB2 HDAC1 HOXB13 ID1 ID2 ID3 KLF4 MAD2L2 MAP2K1 MAP2K3 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9 MOB4 PIAS2 SNCA SRF STARD3NL STK16 TAOK2 UBC UBE2I	47 interactors: ADAMTSL4 AES ALS2CR12 CALCOCO2 CCDC33 CRX CSNK2B DNAJA3 DRG1 EFEMP2 EFHC2 ELK1 FAM154A IKZF3 INCA1 KCTD14 KCTD17 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP13-1 KRTAP26-1 MBP MEOX2 MGAT5B MIIP MTUS2 NAGK NIF3L1 NOTCH2NL PCSK5 PLSCR1 PLSCR3 REL RFX6 RPIA SKIL SPRY2 TCF12 TCF4 TNFAIP1 TRAF3IP2 TRIM27 TRIM42 TRIP6
Entrez ID		2002	8576
HPRD ID		02407	05281
Ensembl ID		ENSG00000126767	ENSG00000115661
Uniprot IDs		P19419 Q86SR6	O75716
PDB IDs		1DUX	2BUJ
Enriched GO Terms of Interacting Partners?		Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Stress-activated MAPK Cascade Positive Regulation Of Metabolic Process Stress-activated Protein Kinase Signaling Cascade Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Toll-like Receptor Signaling Pathway Regulation Of RNA Biosynthetic Process Cellular Response To Stress Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Macromolecule Biosynthetic Process MAPK Cascade Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Regulation Of Signaling Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Positive Regulation Of Innate Immune Response Signal Transduction By Phosphorylation Response To Growth Factor Innate Immune Response Response To Stress Immune System Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Innate Immune Response Cellular Response To Organic Substance Transcription, DNA-templated Immune Response Regulation Of Phosphorylation RNA Biosynthetic Process	Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Immune System Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Cytokine Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Response To Organic Substance Positive Regulation Of Cell Death Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Cell Death Positive Regulation Of Cellular Biosynthetic Process RNA Metabolic Process Immune Response Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Phospholipid Scrambling Regulation Of Nitrogen Compound Metabolic Process Gene Expression Positive Regulation Of Apoptotic Process Regulation Of Signaling Positive Regulation Of Programmed Cell Death Negative Regulation Of Protein Kinase Activity Regulation Of Signal Transduction Response To Stimulus Positive Regulation Of Signal Transduction Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Oligomerization Regulation Of Transcription, DNA-templated Negative Regulation Of Kinase Activity Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Metabolic Process Protein Homooligomerization Developmental Process Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of RNA Metabolic Process Cell Death Death
Tagcloud ?		activate activated atf2 hearts hypertrophic ischemia jnk jun kd mapk mapkapk2 mapks mekk1 myocyte myocytes perfused reactivating reperfusion rk sapks sek1 speculate stimulates stresses subfamily superfamily transactivating transfection ventricular
Tagcloud (Difference) ?		activate activated atf2 hearts hypertrophic ischemia jnk jun kd mapk mapkapk2 mapks mekk1 myocyte myocytes perfused reactivating reperfusion rk sapks sek1 speculate stimulates stresses subfamily superfamily transactivating transfection ventricular
Tagcloud (Intersection) ?