ELK1 and TAOK2

Number of citations of the paper that reports this interaction (PMID 12665513)
9

Data Source:
HPRD (in vitro)

		ELK1	TAOK2
Gene Name		ELK1, member of ETS oncogene family	TAO kinase 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Dendrite Neuronal Cell Body Axon Terminus	Nucleus Nucleolus Cytoplasm Cytoskeleton Integral Component Of Membrane Cytoplasmic Membrane-bounded Vesicle Dendrite Cytoplasmic Vesicle Membrane Receptor Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Core Promoter Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity ATP Binding Mitogen-activated Protein Kinase Kinase Binding
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter Response To Light Stimulus Cell Differentiation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Innate Immune Response Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Stress-activated MAPK Cascade Cellular Response To Testosterone Stimulus Cellular Response To Gamma Radiation Positive Regulation Of Neuron Death	Activation Of MAPKK Activity Regulation Of Cell Growth Protein Phosphorylation Protein Targeting To Membrane Apoptotic Process Response To Stress Cellular Response To DNA Damage Stimulus Regulation Of Cell Shape Cell Migration Actin Cytoskeleton Organization G2 DNA Damage Checkpoint Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of JNK Cascade Focal Adhesion Assembly Stress-activated MAPK Cascade
Pathways		Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade ERK/MAPK targets Innate Immune System Signalling by NGF TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 3 (TLR3) Cascade ERK/MAPK targets Toll Like Receptor 4 (TLR4) Cascade MAPK targets/ Nuclear events mediated by MAP kinases Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS
Protein-Protein Interactions		38 interactors: APP BRCA1 CDK6 CEBPB CREBBP EMX1 EP300 EWSR1 FBXO25 FLI1 FOS GRB10 GRB2 HDAC1 HOXB13 ID1 ID2 ID3 KLF4 MAD2L2 MAP2K1 MAP2K3 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9 MOB4 PIAS2 SNCA SRF STARD3NL STK16 TAOK2 UBC UBE2I	9 interactors: ELK1 KLHL12 MAP2K3 MAP2K6 MEGF10 RCHY1 TUBA1A TUBA4A TUBB
Entrez ID		2002	9344
HPRD ID		02407	18147
Ensembl ID		ENSG00000126767	ENSG00000149930
Uniprot IDs		P19419 Q86SR6	Q9UL54
PDB IDs		1DUX
Enriched GO Terms of Interacting Partners?		Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Stress-activated MAPK Cascade Positive Regulation Of Metabolic Process Stress-activated Protein Kinase Signaling Cascade Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Toll-like Receptor Signaling Pathway Regulation Of RNA Biosynthetic Process Cellular Response To Stress Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Macromolecule Biosynthetic Process MAPK Cascade Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Regulation Of Signaling Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Positive Regulation Of Innate Immune Response Signal Transduction By Phosphorylation Response To Growth Factor Innate Immune Response Response To Stress Immune System Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Innate Immune Response Cellular Response To Organic Substance Transcription, DNA-templated Immune Response Regulation Of Phosphorylation RNA Biosynthetic Process	Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Protein Polymerization Toll-like Receptor Signaling Pathway Stress-activated MAPK Cascade G2/M Transition Of Mitotic Cell Cycle Stress-activated Protein Kinase Signaling Cascade Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response MAPK Cascade Regulation Of Innate Immune Response Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cellular Response To Interleukin-4 Signal Transduction By Phosphorylation Innate Immune Response Response To Interleukin-4 Cardiac Muscle Contraction 'de Novo' Posttranslational Protein Folding Cellular Protein Complex Assembly 'de Novo' Protein Folding Heart Contraction Protein Complex Assembly Cell Cycle Process Skeletal Muscle Satellite Cell Proliferation Striated Muscle Contraction Microtubule Cytoskeleton Organization Immune Response-regulating Signaling Pathway Cellular Response To Testosterone Stimulus Skeletal Muscle Cell Proliferation Skeletal Muscle Satellite Cell Activation Immune Response Defense Response Cell Cycle Cellular Response To Sorbitol Cytoskeleton-dependent Intracellular Transport Activation Of MAPK Activity Cellular Macromolecular Complex Assembly Positive Regulation Of Immune Response
Tagcloud ?		activate activated atf2 hearts hypertrophic ischemia jnk jun kd mapk mapkapk2 mapks mekk1 myocyte myocytes perfused reactivating reperfusion rk sapks sek1 speculate stimulates stresses subfamily superfamily transactivating transfection ventricular
Tagcloud (Difference) ?		activate activated atf2 hearts hypertrophic ischemia jnk jun kd mapk mapkapk2 mapks mekk1 myocyte myocytes perfused reactivating reperfusion rk sapks sek1 speculate stimulates stresses subfamily superfamily transactivating transfection ventricular
Tagcloud (Intersection) ?