CRTC2 and SIK1

Number of citations of the paper that reports this interaction (PMID 16306228)
29

Data Source:
HPRD (in vitro, in vivo)

		CRTC2	SIK1
Gene Name		CREB regulated transcription coactivator 2	salt-inducible kinase 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Extracellular Vesicular Exosome	Nucleus Cytoplasm
	Molecular Function	Protein Binding CAMP Response Element Binding Protein Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding CAMP Response Element Binding Protein Binding Protein Kinase Binding 14-3-3 Protein Binding
	Biological Process	Gluconeogenesis Transcription, DNA-templated Viral Process Positive Regulation Of CREB Transcription Factor Activity Glucose Homeostasis Histone H3-K9 Acetylation Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Homotetramerization Toxin Transport	Regulation Of Sodium Ion Transport Protein Phosphorylation Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Myotube Differentiation Negative Regulation Of Triglyceride Biosynthetic Process Negative Regulation Of CREB Transcription Factor Activity Intracellular Signal Transduction Entrainment Of Circadian Clock By Photoperiod Regulation Of Cell Differentiation Negative Regulation Of Gluconeogenesis Protein Autophosphorylation Rhythmic Process Cardiac Muscle Cell Differentiation Positive Regulation Of Anoikis
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: PPP3CA PRKAA1 SIK1 SIK2 SIK3 UBC YWHAB YWHAG YWHAZ	9 interactors: CRTC2 HDAC5 NMNAT1 PRKACA RPL3 STK11 SUPT5H VAPA YWHAZ
Entrez ID		200186	150094
HPRD ID		12347	09301
Ensembl ID		ENSG00000160741	ENSG00000142178
Uniprot IDs		Q53ET0	P57059
PDB IDs		4HTM
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Phosphate-containing Compound Metabolic Process Phosphorylation Intracellular Signal Transduction Cellular Response To Insulin Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Mitochondrion Organization Positive Regulation Of Intracellular Transport Positive Regulation Of Cell Death Response To Insulin Cellular Response To Peptide Hormone Stimulus Regulation Of Apoptotic Process Cellular Response To Peptide Regulation Of Protein Localization Regulation Of Mitochondrion Organization Apoptotic Signaling Pathway Regulation Of Cell Death Response To Organonitrogen Compound Protein Targeting Regulation Of Intracellular Transport Response To Peptide Hormone Cellular Response To Organic Substance Cellular Response To Organonitrogen Compound Regulation Of Signaling Response To Peptide Insulin Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway Cellular Response To Hormone Stimulus Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Apoptotic Signaling Pathway Cell Cycle Fc-epsilon Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Establishment Of Protein Localization Signaling Cell Communication Response To Organic Substance Mitotic Cell Cycle Phase Transition Positive Regulation Of Transport Regulation Of Protein Kinase Activity Cell Cycle Phase Transition Intracellular Transport Fc Receptor Signaling Pathway Activation Of Protein Kinase Activity Negative Regulation Of Lipid Biosynthetic Process Regulation Of Kinase Activity	Golgi Localization Intrinsic Apoptotic Signaling Pathway Chromatin Modification Glucose Homeostasis Cell Activation Histone H3-K9 Modification Chromatin Organization Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Peptide Hormone Stimulus Membrane Organization Response To Glucagon Gluconeogenesis Cellular Response To Peptide Apoptotic Signaling Pathway Hexose Biosynthetic Process Organelle Organization Positive Regulation Of Viral Process Histone Modification Biosynthetic Process Chromosome Organization Positive Regulation Of Dense Core Granule Biogenesis TCR Signalosome Assembly Cell Death Death Cellular Metabolic Process Gene Expression Response To Peptide Hormone Cellular Response To Light Stimulus Cellular Response To Organonitrogen Compound Leukocyte Activation Response To Peptide Regulation Of Endothelial Cell Migration Protein Localization To Organelle Histone H3-K9 Acetylation Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Histone H3-T6 Phosphorylation Negative Regulation By Host Of Viral Genome Replication Positive Regulation By Host Of Viral Release From Host Cell Positive Regulation Of Signal Transduction Viral Process Protein Localization To Endoplasmic Reticulum Regulation Of Osteoblast Differentiation Cellular Response To Hormone Stimulus Response To Organic Substance Energy Reserve Metabolic Process Spermatid Development Cellular Response To Radiation Positive Regulation Of Cellular Metabolic Process Glucose Metabolic Process
Tagcloud ?		autocrine calcitonin cgrp cofactor competes costimulatory creb crtc3 engagement enhancing exhibits glycoprotein herpesvirus hsv lymphotoxin macrophage macrophages mediator modulates nerves neuroimmunological neuropeptide shape sphingosine sphk1 stimulatory sustained tlr4	angptl4 api5 asap1 cebpb cpp ctbbd1 homer1 itgb6 jam2 letm1 methylphenidate mitochondrion nfkbia notch3 nsbp1 overrepresented pcdh10 per3 perp pfc prps18c reinforcer s100a9 shrs stimulant taf1 ube2d2 uqcrc2 usp27x
Tagcloud (Difference) ?		autocrine calcitonin cgrp cofactor competes costimulatory creb crtc3 engagement enhancing exhibits glycoprotein herpesvirus hsv lymphotoxin macrophage macrophages mediator modulates nerves neuroimmunological neuropeptide shape sphingosine sphk1 stimulatory sustained tlr4	angptl4 api5 asap1 cebpb cpp ctbbd1 homer1 itgb6 jam2 letm1 methylphenidate mitochondrion nfkbia notch3 nsbp1 overrepresented pcdh10 per3 perp pfc prps18c reinforcer s100a9 shrs stimulant taf1 ube2d2 uqcrc2 usp27x
Tagcloud (Intersection) ?