CRTC2 and PRKAA1

Number of citations of the paper that reports this interaction (PMID 22462548)
7

Data Source:
BioGRID (enzymatic study)

		CRTC2	PRKAA1
Gene Name		CREB regulated transcription coactivator 2	protein kinase, AMP-activated, alpha 1 catalytic subunit
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Extracellular Vesicular Exosome	Intracellular Nucleus Nucleoplasm Cytoplasm Cytosol Apical Plasma Membrane AMP-activated Protein Kinase Complex
	Molecular Function	Protein Binding CAMP Response Element Binding Protein Binding	Chromatin Binding Protein Kinase Activity AMP-activated Protein Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding Protein C-terminus Binding Kinase Binding Histone Serine Kinase Activity Metal Ion Binding [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Tau-protein Kinase Activity [acetyl-CoA Carboxylase] Kinase Activity
	Biological Process	Gluconeogenesis Transcription, DNA-templated Viral Process Positive Regulation Of CREB Transcription Factor Activity Glucose Homeostasis Histone H3-K9 Acetylation Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Homotetramerization Toxin Transport	Activation Of MAPK Activity Response To Hypoxia Glucose Metabolic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Fatty Acid Biosynthetic Process Cholesterol Biosynthetic Process Autophagy Cell Cycle Arrest Signal Transduction Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Lipid Biosynthetic Process Response To UV Cold Acclimation Response To Gamma Radiation Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Response To Activity Wnt Signaling Pathway Fatty Acid Oxidation Response To Caffeine Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling Histone-serine Phosphorylation Cellular Response To Glucose Starvation Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Glycolytic Process Negative Regulation Of Glucosylceramide Biosynthetic Process Rhythmic Process Negative Regulation Of Lipid Catabolic Process Protein Heterooligomerization Fatty Acid Homeostasis Regulation Of Vesicle-mediated Transport Cellular Response To Hydrogen Peroxide Cellular Response To Ethanol Cellular Response To Hypoxia Response To Camptothecin Regulation Of Energy Homeostasis Negative Regulation Of Glucose Import In Response To Insulin Stimulus
Pathways			Insulin receptor signalling cascade Regulation of AMPK activity via LKB1 IRS-mediated signalling Regulation of Rheb GTPase activity by AMPK mTOR signalling IRS-related events mTOR signalling IGF1R signaling cascade IRS-related events triggered by IGF1R IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade PKB-mediated events PI3K Cascade Signaling by Insulin receptor
Drugs			Adenosine monophosphate Adenosine triphosphate Phenformin
Diseases
GWAS			Gastric cancer ( 22037551)
Protein-Protein Interactions		9 interactors: PPP3CA PRKAA1 SIK1 SIK2 SIK3 UBC YWHAB YWHAG YWHAZ	58 interactors: ABI2 ACACA AES BHLHE40 CAB39 CDX4 CFTR CRTC2 CTBP1 EEF2K EPM2A FNIP1 GATA1 GOLGA2 GRIK2 HDAC5 HMBOX1 HOMEZ IKZF3 INO80E KRT40 L3MBTL3 MAP3K7 MDM4 MORC4 MTOR MTUS2 PFKFB2 PHC2 PLEKHA4 PNMA5 PPP2CA PRKAB1 PRKAB2 PRKAG1 PRKAG3 PSMD11 RAD54B RAF1 RBPMS RFX6 RIMBP3 ROPN1 RPTOR SRPK2 SSX2IP STK11 THAP1 TOMM34 TRIM27 TRIP6 TSC2 TSC22D4 TXNIP UBXN11 VPS37B VPS52 ZBED1
Entrez ID		200186	5562
HPRD ID		12347	04115
Ensembl ID		ENSG00000160741	ENSG00000132356
Uniprot IDs		Q53ET0	Q13131
PDB IDs		4HTM
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Phosphate-containing Compound Metabolic Process Phosphorylation Intracellular Signal Transduction Cellular Response To Insulin Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Mitochondrion Organization Positive Regulation Of Intracellular Transport Positive Regulation Of Cell Death Response To Insulin Cellular Response To Peptide Hormone Stimulus Regulation Of Apoptotic Process Cellular Response To Peptide Regulation Of Protein Localization Regulation Of Mitochondrion Organization Apoptotic Signaling Pathway Regulation Of Cell Death Response To Organonitrogen Compound Protein Targeting Regulation Of Intracellular Transport Response To Peptide Hormone Cellular Response To Organic Substance Cellular Response To Organonitrogen Compound Regulation Of Signaling Response To Peptide Insulin Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway Cellular Response To Hormone Stimulus Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Apoptotic Signaling Pathway Cell Cycle Fc-epsilon Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Establishment Of Protein Localization Signaling Cell Communication Response To Organic Substance Mitotic Cell Cycle Phase Transition Positive Regulation Of Transport Regulation Of Protein Kinase Activity Cell Cycle Phase Transition Intracellular Transport Fc Receptor Signaling Pathway Activation Of Protein Kinase Activity Negative Regulation Of Lipid Biosynthetic Process Regulation Of Kinase Activity	Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Response To Insulin Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Response To Peptide Hormone Cellular Response To Hormone Stimulus Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Response To Hormone Cell Cycle Arrest Regulation Of Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Kinase Activity Gene Expression Response To Organonitrogen Compound Transcription, DNA-templated Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Cycle Regulation Of Protein Kinase Activity Positive Regulation Of Protein Modification Process RNA Biosynthetic Process Regulation Of Cell Cycle Regulation Of Protein Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Ketone Metabolic Process Biosynthetic Process Cell Cycle Response To Organic Substance Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Phosphorylation Cellular Response To Organic Substance Protein Oligomerization RNA Metabolic Process Positive Regulation Of Protein Phosphorylation Protein Heterooligomerization Negative Regulation Of Transcription, DNA-templated Protein Phosphorylation
Tagcloud ?		autocrine calcitonin cgrp cofactor competes costimulatory creb crtc3 engagement enhancing exhibits glycoprotein herpesvirus hsv lymphotoxin macrophage macrophages mediator modulates nerves neuroimmunological neuropeptide shape sphingosine sphk1 stimulatory sustained tlr4	abeta anticipate atg7 autophagic autophagy catabolic clearance cultures degraded degrades enhancing extracellular fibrils inflammasome ingests interacts knockout lysosomal map1lc3b microglia microglial native nlr nlrp3 optineurin optn promising pyrin resultant
Tagcloud (Difference) ?		autocrine calcitonin cgrp cofactor competes costimulatory creb crtc3 engagement exhibits glycoprotein herpesvirus hsv lymphotoxin macrophage macrophages mediator modulates nerves neuroimmunological neuropeptide shape sphingosine sphk1 stimulatory sustained tlr4	abeta anticipate atg7 autophagic autophagy catabolic clearance cultures degraded degrades extracellular fibrils inflammasome ingests interacts knockout lysosomal map1lc3b microglia microglial native nlr nlrp3 optineurin optn promising pyrin resultant
Tagcloud (Intersection) ?		enhancing