SIK1 and VAPA

Number of citations of the paper that reports this interaction (PMID 9920726)
31

Data Source:
HPRD (in vitro)

		SIK1	VAPA
Gene Name		salt-inducible kinase 1	VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Tight Junction Microtubule Cytoskeleton Integral Component Of Membrane Vesicle Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Exit Site
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding CAMP Response Element Binding Protein Binding Protein Kinase Binding 14-3-3 Protein Binding	Signal Transducer Activity Protein Binding Microtubule Binding Protein Domain Specific Binding FFAT Motif Binding Protein Heterodimerization Activity
	Biological Process	Regulation Of Sodium Ion Transport Protein Phosphorylation Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Myotube Differentiation Negative Regulation Of Triglyceride Biosynthetic Process Negative Regulation Of CREB Transcription Factor Activity Intracellular Signal Transduction Entrainment Of Circadian Clock By Photoperiod Regulation Of Cell Differentiation Negative Regulation Of Gluconeogenesis Protein Autophosphorylation Rhythmic Process Cardiac Muscle Cell Differentiation Positive Regulation Of Anoikis	Sphingolipid Metabolic Process ER To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Signal Transduction Cell Death Sphingolipid Biosynthetic Process Neuron Projection Development Protein Folding In Endoplasmic Reticulum Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Small Molecule Metabolic Process Positive Regulation By Host Of Viral Release From Host Cell Negative Regulation By Host Of Viral Genome Replication Positive Regulation By Host Of Viral Genome Replication Membrane Fusion Protein Localization To Endoplasmic Reticulum COPII-coated Vesicle Budding
Pathways			Sphingolipid metabolism Metabolism of lipids and lipoproteins Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS			Pulmonary function (interaction) ( 23284291)
Protein-Protein Interactions		9 interactors: CRTC2 HDAC5 NMNAT1 PRKACA RPL3 STK11 SUPT5H VAPA YWHAZ	15 interactors: ADRB2 APOD APP CACNG1 EGFR GPR128 NSF OPRM1 OSBP RMDN3 SIK1 VAMP1 VAMP2 VAPB ZBTB22
Entrez ID		150094	9218
HPRD ID		09301	09299
Ensembl ID		ENSG00000142178	ENSG00000101558
Uniprot IDs		P57059	Q9P0L0
PDB IDs			2RR3
Enriched GO Terms of Interacting Partners?		Golgi Localization Intrinsic Apoptotic Signaling Pathway Chromatin Modification Glucose Homeostasis Cell Activation Histone H3-K9 Modification Chromatin Organization Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Peptide Hormone Stimulus Membrane Organization Response To Glucagon Gluconeogenesis Cellular Response To Peptide Apoptotic Signaling Pathway Hexose Biosynthetic Process Organelle Organization Positive Regulation Of Viral Process Histone Modification Biosynthetic Process Chromosome Organization Positive Regulation Of Dense Core Granule Biogenesis TCR Signalosome Assembly Cell Death Death Cellular Metabolic Process Gene Expression Response To Peptide Hormone Cellular Response To Light Stimulus Cellular Response To Organonitrogen Compound Leukocyte Activation Response To Peptide Regulation Of Endothelial Cell Migration Protein Localization To Organelle Histone H3-K9 Acetylation Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Histone H3-T6 Phosphorylation Negative Regulation By Host Of Viral Genome Replication Positive Regulation By Host Of Viral Release From Host Cell Positive Regulation Of Signal Transduction Viral Process Protein Localization To Endoplasmic Reticulum Regulation Of Osteoblast Differentiation Cellular Response To Hormone Stimulus Response To Organic Substance Energy Reserve Metabolic Process Spermatid Development Cellular Response To Radiation Positive Regulation Of Cellular Metabolic Process Glucose Metabolic Process	Metal Ion Homeostasis Ion Homeostasis Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Cellular Localization Exocytosis Membrane Fusion Cellular Metal Ion Homeostasis Golgi To Plasma Membrane Protein Transport Establishment Of Localization In Cell Homeostatic Process Membrane Organization Cellular Cation Homeostasis Chemical Homeostasis Cellular Ion Homeostasis Vesicle-mediated Transport Transport Intracellular Transport Golgi To Plasma Membrane Transport Secretion By Cell Cellular Chemical Homeostasis Vesicle Organization Regulation Of Cellular Localization Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Vasodilation Establishment Of Protein Localization To Membrane Vesicle Fusion Regulation Of Ion Transport Regulation Of Protein Transport Secretion Regulation Of Intracellular Protein Transport Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Golgi Vesicle Transport Regulation Of Adenylate Cyclase Activity Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Establishment Of Protein Localization Negative Regulation Of Wnt Protein Secretion Alkanesulfonate Metabolic Process Negative Regulation Of T Cell Migration Negative Regulation Of Lipoprotein Lipid Oxidation Negative Regulation By Host Of Viral Release From Host Cell Cytoplasmic Transport Cellular Homeostasis Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Cyclase Activity Regulation Of Sodium Ion Transport Regulation Of Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Tagcloud ?		angptl4 api5 asap1 cebpb cpp ctbbd1 homer1 itgb6 jam2 letm1 methylphenidate mitochondrion nfkbia notch3 nsbp1 overrepresented pcdh10 per3 perp pfc prps18c reinforcer s100a9 shrs stimulant taf1 ube2d2 uqcrc2 usp27x	abolished acetate acidic akts473 beta1 canonical consistently disruption ffat homolog homology hyperphosphorylated integrin interacting mechanistic motif myristate orp3 oxysterol phenylalanines phorbol pleckstrin pm pma ras requirements selectively stimulate subcellular
Tagcloud (Difference) ?		angptl4 api5 asap1 cebpb cpp ctbbd1 homer1 itgb6 jam2 letm1 methylphenidate mitochondrion nfkbia notch3 nsbp1 overrepresented pcdh10 per3 perp pfc prps18c reinforcer s100a9 shrs stimulant taf1 ube2d2 uqcrc2 usp27x	abolished acetate acidic akts473 beta1 canonical consistently disruption ffat homolog homology hyperphosphorylated integrin interacting mechanistic motif myristate orp3 oxysterol phenylalanines phorbol pleckstrin pm pma ras requirements selectively stimulate subcellular
Tagcloud (Intersection) ?