CRTC2 and SIK3

Number of citations of the paper that reports this interaction (PMID 16306228)
29

Data Source:
HPRD (in vivo, in vitro)

		CRTC2	SIK3
Gene Name		CREB regulated transcription coactivator 2	SIK family kinase 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Extracellular Vesicular Exosome	Cytoplasm
	Molecular Function	Protein Binding CAMP Response Element Binding Protein Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Gluconeogenesis Transcription, DNA-templated Viral Process Positive Regulation Of CREB Transcription Factor Activity Glucose Homeostasis Histone H3-K9 Acetylation Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Homotetramerization Toxin Transport	Endochondral Ossification Protein Phosphorylation Regulation Of Protein Localization Limb Morphogenesis Multicellular Organism Growth Cartilage Development Involved In Endochondral Bone Morphogenesis
Pathways
Drugs
Diseases
GWAS			Response to Vitamin E supplementation ( 22437554)
Protein-Protein Interactions		9 interactors: PPP3CA PRKAA1 SIK1 SIK2 SIK3 UBC YWHAB YWHAG YWHAZ	6 interactors: CRTC2 HDAC5 PRKACA TRAF1 TRIP6 YWHAZ
Entrez ID		200186	23387
HPRD ID		12347	11121
Ensembl ID		ENSG00000160741	ENSG00000160584
Uniprot IDs		Q53ET0	A1A5A8 A1A5A9 H0Y494 J3KPC8 Q9Y2K2
PDB IDs		4HTM
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Phosphate-containing Compound Metabolic Process Phosphorylation Intracellular Signal Transduction Cellular Response To Insulin Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Mitochondrion Organization Positive Regulation Of Intracellular Transport Positive Regulation Of Cell Death Response To Insulin Cellular Response To Peptide Hormone Stimulus Regulation Of Apoptotic Process Cellular Response To Peptide Regulation Of Protein Localization Regulation Of Mitochondrion Organization Apoptotic Signaling Pathway Regulation Of Cell Death Response To Organonitrogen Compound Protein Targeting Regulation Of Intracellular Transport Response To Peptide Hormone Cellular Response To Organic Substance Cellular Response To Organonitrogen Compound Regulation Of Signaling Response To Peptide Insulin Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway Cellular Response To Hormone Stimulus Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Apoptotic Signaling Pathway Cell Cycle Fc-epsilon Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Establishment Of Protein Localization Signaling Cell Communication Response To Organic Substance Mitotic Cell Cycle Phase Transition Positive Regulation Of Transport Regulation Of Protein Kinase Activity Cell Cycle Phase Transition Intracellular Transport Fc Receptor Signaling Pathway Activation Of Protein Kinase Activity Negative Regulation Of Lipid Biosynthetic Process Regulation Of Kinase Activity	Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Component Assembly Positive Regulation Of Intracellular Transport Histone H3-K9 Modification Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Blood Vessel Endothelial Cell Migration Gluconeogenesis Histone Modification Hexose Biosynthetic Process Regulation Of Intracellular Transport Positive Regulation Of Dense Core Granule Biogenesis Regulation Of Cell Migration Regulation Of Endothelial Cell Migration Positive Regulation Of Nucleocytoplasmic Transport Chromatin Modification Regulation Of Cell Motility Gene Expression Regulation Of Osteoblast Differentiation Regulation Of Establishment Of Protein Localization Cell Activation Regulation Of Locomotion Regulation Of Cellular Component Movement Histone H3-K9 Acetylation Histone H3-T6 Phosphorylation Chromatin Organization Glucose Metabolic Process Regulation Of Epithelial Cell Migration Positive Regulation Of Transport Regulation Of Protein Binding Carbohydrate Biosynthetic Process Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Localization Intrinsic Apoptotic Signaling Pathway Golgi Reassembly Platelet Activation Regulation Of Ossification Cell Junction Assembly Glucose Homeostasis Hexose Metabolic Process Cell-cell Junction Organization Regulation Of Nucleocytoplasmic Transport Release Of Cytoplasmic Sequestered NF-kappaB Apoptotic Process Regulation Of Angiogenesis Programmed Cell Death Histamine Secretion By Mast Cell Chromosome Organization Regulation Of Cellular Localization Cell Death Death
Tagcloud ?		autocrine calcitonin cgrp cofactor competes costimulatory creb crtc3 engagement enhancing exhibits glycoprotein herpesvirus hsv lymphotoxin macrophage macrophages mediator modulates nerves neuroimmunological neuropeptide shape sphingosine sphk1 stimulatory sustained tlr4	aicar ampk ampkbeta blunted brsk1 brsk2 c433s caax cys433 farnesylated farnesylation fertile imidazolecarboxamide knockin lkb1 lkb1c433s lkb1s431a mark4 mimetic myristoylation nuak nuak1 phenformin prenylated raises riboside s431a ser431 snf1
Tagcloud (Difference) ?		autocrine calcitonin cgrp cofactor competes costimulatory creb crtc3 engagement enhancing exhibits glycoprotein herpesvirus hsv lymphotoxin macrophage macrophages mediator modulates nerves neuroimmunological neuropeptide shape sphingosine sphk1 stimulatory sustained tlr4	aicar ampk ampkbeta blunted brsk1 brsk2 c433s caax cys433 farnesylated farnesylation fertile imidazolecarboxamide knockin lkb1 lkb1c433s lkb1s431a mark4 mimetic myristoylation nuak nuak1 phenformin prenylated raises riboside s431a ser431 snf1
Tagcloud (Intersection) ?