EIF4A2 and TK1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		EIF4A2	TK1
Gene Name		eukaryotic translation initiation factor 4A2	thymidine kinase 1, soluble
Image
Gene Ontology Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 4F Complex Perinuclear Region Of Cytoplasm	Cytosol
	Molecular Function	Translation Initiation Factor Activity Helicase Activity Protein Binding ATP Binding ATPase Activity Poly(A) RNA Binding	Thymidine Kinase Activity ATP Binding Zinc Ion Binding Nucleoside Kinase Activity Identical Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Viral Process Cytokine-mediated Signaling Pathway Cellular Protein Metabolic Process Negative Regulation Of RNA-directed RNA Polymerase Activity	Liver Development Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleobase Metabolic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Nucleotide Biosynthetic Process Response To Toxic Substance Skeletal Muscle Cell Proliferation Phosphorylation Response To Nutrient Levels Pyrimidine Nucleoside Salvage Small Molecule Metabolic Process Thymidine Metabolic Process Response To Copper Ion Digestive Tract Development Protein Homotetramerization Response To Cortisol Nucleobase-containing Small Molecule Metabolic Process Fetal Process Involved In Parturition DNA Biosynthetic Process
Pathways		Translation initiation complex formation Translation Deadenylation of mRNA ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system L13a-mediated translational silencing of Ceruloplasmin expression Antiviral mechanism by IFN-stimulated genes Deadenylation-dependent mRNA decay Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Cap-dependent Translation Initiation	Pyrimidine salvage reactions Pyrimidine metabolism Metabolism of nucleotides
Drugs			Dithioerythritol Thymidine-5\'-Triphosphate
Diseases
GWAS
Protein-Protein Interactions		17 interactors: BRCA1 CLNS1A DPPA4 ECT2 EIF4G1 EIF4G2 IPO11 MDFI NEK2 PDCD4 PFDN1 PIH1D2 SLC16A9 SSX2IP TK1 TRIM36 TRIM39	159 interactors: A1BG A2M AAMP ABHD4 ACTB ACTL6B ACTR1B ADAMTS10 ADD1 AGAP1 ALAS1 ALB APLP1 APP ARFGAP1 ASNA1 ATG16L2 ATP5B ATP6V1A ATXN3 BAG6 C14orf1 C19orf60 CARHSP1 CCDC115 CCDC90B CDC20 CDK1 CDK4 CDKN1A CENPB CHGB CLEC3B COL11A2 COL4A2 COL4A5 COPS6 CPNE6 CPSF3L CRIP2 CRMP1 CSAD DACT1 DALRD3 DCAF13 DDAH2 DEAF1 DMPK DOCK7 DRAP1 DUS2 DYNC1I1 EEF1A1 EIF3G EIF4A2 EIF6 EXT2 EZH2 F13A1 FAF1 FAM20C FBN3 FGB FLAD1 FST FZR1 GAPDH GDF9 GDI1 GLB1 GPCPD1 HADHB HERC3 HMGXB3 HSPBAP1 IER3IP1 IGHM IMMT INPP5K ITSN1 JADE1 JMJD1C KDM6B KIF21B KIF5A KLHL23 KLHL5 KMT2B LOC148413 LRIF1 MAGEA4 MAST2 MED31 METTL23 MKI67 MPP1 MPPED1 MRFAP1 MRPL37 MSH2 NEUROD2 NGFR NKIRAS2 NMT2 NRBP1 ODC1 PAAF1 PDE4DIP PKM PLD3 PLXNA3 PPP4C PROC PSME1 PTPN4 PTPRK QARS RBBP4 RBM48 RPA1 RPL13 RPS2 RUVBL1 RXRA SDF4 SEMA5B SEPT6 SETDB1 SEZ6L2 SMC5 SNX1 SP110 SULT1A3 SUMO3 TAF1C TCTEX1D2 THOC3 TIAM2 TLE1 TMSB4X TP53 TRIM46 TRMT2A TSC2 TTC38 TUBA1A TUBB2A TUBB3 TYK2 UNC119 UPF2 USP4 WDR18 WDR60 WDR73 WIZ ZBTB16 ZNF431 ZXDC
Entrez ID		1974	7083
HPRD ID		03062	01771
Ensembl ID		ENSG00000156976	ENSG00000167900
Uniprot IDs		Q14240 Q9NZE6	P04183
PDB IDs		3BOR	1W4R 1XBT 2ORV 2WVJ
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Centrosome Organization Microtubule Organizing Center Organization Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Microtubule Cytoskeleton Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Microtubule-based Process Regulation Of Protein Metabolic Process Negative Regulation Of DNA Binding Cell Death Death Regulation Of Centrosome Cycle Centrosome Cycle Positive Regulation Of Histone H4-K20 Methylation Negative Regulation Of Centriole-centriole Cohesion Positive Regulation Of Histone H4-K16 Acetylation Fetal Process Involved In Parturition Regulation Of Translational Initiation Regulation Of JUN Kinase Activity Skeletal Muscle Cell Proliferation Positive Regulation Of Histone H3-K9 Acetylation Regulation Of Chromosome Segregation Cell Cycle Regulation Of DNA Binding Embryo Development Ending In Birth Or Egg Hatching Negative Regulation Of Binding Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Regulation Of Centriole-centriole Cohesion Microtubule Cytoskeleton Organization Negative Regulation Of Cell Cycle Apoptotic Process Cellular Response To Indole-3-methanol Regulation Of Mitotic Centrosome Separation Programmed Cell Death Regulation Of Cell Cycle Process Developmental Process Ribosomal Protein Import Into Nucleus Intraciliary Transport Involved In Cilium Morphogenesis Negative Regulation Of Centriole Replication Response To Cortisol Thymidine Metabolic Process Cell Cycle Process Regulation Of Cytoskeleton Organization Response To Ionizing Radiation Dosage Compensation By Inactivation Of X Chromosome Deoxyribonucleoside Monophosphate Biosynthetic Process Protein K6-linked Ubiquitination Regulation Of JNK Cascade Negative Regulation Of Cytoskeleton Organization	Cellular Metabolic Process Regulation Of Protein Metabolic Process Cellular Protein Metabolic Process Developmental Process Anatomical Structure Development System Development Regulation Of Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Multicellular Organismal Development Cellular Localization Metabolic Process Regulation Of Metabolic Process Organelle Organization Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Protein Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Catabolic Process RNA Metabolic Process Negative Regulation Of Cell Cycle Posttranscriptional Regulation Of Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Cell Differentiation Platelet Degranulation Gene Expression Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Cellular Process Biosynthetic Process Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Cell Cycle Process Mitotic Cell Cycle Process Axon Guidance Chromatin Organization Viral Process Programmed Cell Death Negative Regulation Of Mitotic Cell Cycle Phase Transition Chromosome Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Organic Substance Mitotic Cell Cycle Cellular Response To Growth Factor Stimulus
Tagcloud ?		4f adult biogenesis confer deprivation differed differs eif4f eif4g1 fetal gestation helicase hepatocyte insensitive liver nutrient oligopyrimidine preinitiation rapamycin refeeding ribosome sensing top tracts translation weights went	american artiodactyla assigned block blot cattle chr conservative conserved cow electrophoresis erbb2 hybrid hybridization localization localized means mink nf1 pepa pig prkca rara representatives sheep southern swine synteny umph2
Tagcloud (Difference) ?		4f adult biogenesis confer deprivation differed differs eif4f eif4g1 fetal gestation helicase hepatocyte insensitive liver nutrient oligopyrimidine preinitiation rapamycin refeeding ribosome sensing top tracts translation weights went	american artiodactyla assigned block blot cattle chr conservative conserved cow electrophoresis erbb2 hybrid hybridization localization localized means mink nf1 pepa pig prkca rara representatives sheep southern swine synteny umph2
Tagcloud (Intersection) ?