EIF4A2 and MDFI

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		EIF4A2	MDFI
Gene Name		eukaryotic translation initiation factor 4A2	MyoD family inhibitor
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 4F Complex Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm
	Molecular Function	Translation Initiation Factor Activity Helicase Activity Protein Binding ATP Binding ATPase Activity Poly(A) RNA Binding	Protein Binding Transcription Factor Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Viral Process Cytokine-mediated Signaling Pathway Cellular Protein Metabolic Process Negative Regulation Of RNA-directed RNA Polymerase Activity	Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of JUN Kinase Activity Embryo Development Dorsal/ventral Axis Specification Negative Regulation Of Wnt Signaling Pathway Cytoplasmic Sequestering Of Transcription Factor Negative Regulation Of DNA Binding Embryonic Skeletal System Morphogenesis Trophoblast Giant Cell Differentiation
Pathways		Translation initiation complex formation Translation Deadenylation of mRNA ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system L13a-mediated translational silencing of Ceruloplasmin expression Antiviral mechanism by IFN-stimulated genes Deadenylation-dependent mRNA decay Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Cap-dependent Translation Initiation
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: BRCA1 CLNS1A DPPA4 ECT2 EIF4G1 EIF4G2 IPO11 MDFI NEK2 PDCD4 PFDN1 PIH1D2 SLC16A9 SSX2IP TK1 TRIM36 TRIM39	225 interactors: AANAT AASDHPPT ADAMTSL3 AKAP17A AP5Z1 APLN AQP1 AQP5 ARHGAP32 ARID5A ATG12 ATN1 ATXN7L2 AVPI1 B3GNT9 BAALC BAHD1 BBS2 BEX1 C10orf62 C14orf105 C17orf70 C19orf60 C19orf66 C20orf195 C22orf39 C4orf26 C5orf30 C6orf165 C8orf33 C8orf48 CATSPER1 CBFA2T2 CBX2 CC2D1B CCDC116 CCDC120 CCDC185 CCDC33 CCER1 CDC42EP1 CDCA7L CDKL3 CEP57L1 CHIC2 CLPB CNNM3 CPSF3L CREB5 CRX CRY1 CSNK1G2-AS1 CXCL16 CYBA DAAM2 DBF4B DCAF8 DCANP1 DDX19A DHRS1 DKK1 DMRT3 DNPEP DOCK2 DUSP6 EBI3 EIF4A2 EIF4E2 ENKD1 ETNK2 EWSR1 FAM124B FAM161A FAM27E3 FASTK FBXL18 FBXO34 FBXW5 FES FOXD4L6 FZD9 GATA2 GDF15 GLIDR GNAI2 GNG5 GPATCH2L GPRIN2 GTF3C5 HEYL HNRNPLL HOXA1 HOXB9 HTR1B ILF3 IQUB KAT5 KIAA0040 KIAA0408 KIF1A KPNA2 KRAS LASP1 LCE1B LCE3E LCE4A LIMS2 LINC00636 LINC01588 LMO3 LOC148413 LOC149950 LRCH4 LRRN4 MAGED1 MAGEF1 MAPKBP1 MCM5 METTL17 MFSD3 MGAT5B MVP MYF5 MYOD1 MYOG NAB2 NDUFA7 NEU4 NPDC1 NR1H2 NR1H3 OLIG3 OTX1 PARP11 PBXIP1 PDGFB PDIA5 PGLS PHLDA1 PID1 PIDD1 PIH1D2 PIN1 PLEKHG4 POM121L8P PRKAB2 PTPMT1 PVRL2 RABL6 REG3A RFX2 RIPPLY1 RTP5 SERF2 SFI1 SIX1 SLC25A10 SLC35A2 SLC9A1 SPATA3 SPATA8 SPG7 SPRY1 SPRY2 TAP1 TCEB3 TCF3 TGIF1 THAP7 THEG TIE1 TINAGL1 TMEM241 TNNI1 TNP2 TRAF3IP2 TRPC1 TRPV6 TSC2 TTC23 TTLL10 TUSC2 TYMSOS TYRO3 UBC USP20 USP6 VHL VPS72 WDYHV1 WNT11 ZBTB24 ZBTB25 ZBTB9 ZFYVE26 ZNF101 ZNF124 ZNF136 ZNF138 ZNF155 ZNF205 ZNF223 ZNF230 ZNF264 ZNF266 ZNF408 ZNF417 ZNF426 ZNF433 ZNF439 ZNF440 ZNF490 ZNF559 ZNF564 ZNF578 ZNF581 ZNF587 ZNF607 ZNF646 ZNF670 ZNF679 ZNF707 ZNF764 ZNF79 ZNF844
Entrez ID		1974	4188
HPRD ID		03062	07280
Ensembl ID		ENSG00000156976	ENSG00000112559
Uniprot IDs		Q14240 Q9NZE6	B1AKB6 Q99750
PDB IDs		3BOR
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Centrosome Organization Microtubule Organizing Center Organization Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Microtubule Cytoskeleton Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Microtubule-based Process Regulation Of Protein Metabolic Process Negative Regulation Of DNA Binding Cell Death Death Regulation Of Centrosome Cycle Centrosome Cycle Positive Regulation Of Histone H4-K20 Methylation Negative Regulation Of Centriole-centriole Cohesion Positive Regulation Of Histone H4-K16 Acetylation Fetal Process Involved In Parturition Regulation Of Translational Initiation Regulation Of JUN Kinase Activity Skeletal Muscle Cell Proliferation Positive Regulation Of Histone H3-K9 Acetylation Regulation Of Chromosome Segregation Cell Cycle Regulation Of DNA Binding Embryo Development Ending In Birth Or Egg Hatching Negative Regulation Of Binding Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Regulation Of Centriole-centriole Cohesion Microtubule Cytoskeleton Organization Negative Regulation Of Cell Cycle Apoptotic Process Cellular Response To Indole-3-methanol Regulation Of Mitotic Centrosome Separation Programmed Cell Death Regulation Of Cell Cycle Process Developmental Process Ribosomal Protein Import Into Nucleus Intraciliary Transport Involved In Cilium Morphogenesis Negative Regulation Of Centriole Replication Response To Cortisol Thymidine Metabolic Process Cell Cycle Process Regulation Of Cytoskeleton Organization Response To Ionizing Radiation Dosage Compensation By Inactivation Of X Chromosome Deoxyribonucleoside Monophosphate Biosynthetic Process Protein K6-linked Ubiquitination Regulation Of JNK Cascade Negative Regulation Of Cytoskeleton Organization	Transcription, DNA-templated RNA Biosynthetic Process Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Gene Expression Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Biosynthetic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Cellular Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Cellular Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Cellular Metabolic Process Negative Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Developmental Process Cellular Response To Organic Substance Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Multicellular Organismal Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Differentiation Positive Regulation Of Myoblast Fusion Cell Fate Commitment Positive Regulation Of Skeletal Muscle Fiber Development Anatomical Structure Development Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Regulation Of Myoblast Fusion Transcription From RNA Polymerase II Promoter Organ Development Metabolic Process
Tagcloud ?		4f adult biogenesis confer deprivation differed differs eif4f eif4g1 fetal gestation helicase hepatocyte insensitive liver nutrient oligopyrimidine preinitiation rapamycin refeeding ribosome sensing top tracts translation weights went
Tagcloud (Difference) ?		4f adult biogenesis confer deprivation differed differs eif4f eif4g1 fetal gestation helicase hepatocyte insensitive liver nutrient oligopyrimidine preinitiation rapamycin refeeding ribosome sensing top tracts translation weights went
Tagcloud (Intersection) ?