EIF4A2 and PDCD4

Number of citations of the paper that reports this interaction (PMID 17353931)
246

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		EIF4A2	PDCD4
Gene Name		eukaryotic translation initiation factor 4A2	programmed cell death 4 (neoplastic transformation inhibitor)
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Gene Ontology Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 4F Complex Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Translation Initiation Factor Activity Helicase Activity Protein Binding ATP Binding ATPase Activity Poly(A) RNA Binding	RNA Binding Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Viral Process Cytokine-mediated Signaling Pathway Cellular Protein Metabolic Process Negative Regulation Of RNA-directed RNA Polymerase Activity	Apoptotic Process Cell Aging Negative Regulation Of JUN Kinase Activity Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated
Pathways		Translation initiation complex formation Translation Deadenylation of mRNA ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system L13a-mediated translational silencing of Ceruloplasmin expression Antiviral mechanism by IFN-stimulated genes Deadenylation-dependent mRNA decay Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Cap-dependent Translation Initiation
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: BRCA1 CLNS1A DPPA4 ECT2 EIF4G1 EIF4G2 IPO11 MDFI NEK2 PDCD4 PFDN1 PIH1D2 SLC16A9 SSX2IP TK1 TRIM36 TRIM39	12 interactors: APOE BTRC CSNK2A1 EIF4A2 EIF4A3 EIF4G1 PSEN1 PSEN2 RPL5 RPLP1 RPS13 RPS6KA1
Entrez ID		1974	27250
HPRD ID		03062	10549
Ensembl ID		ENSG00000156976	ENSG00000150593
Uniprot IDs		Q14240 Q9NZE6	B4DKX4 Q53EL6
PDB IDs		3BOR	2GGF 2KZT 2RG8 2ZU6 3EIJ
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Centrosome Organization Microtubule Organizing Center Organization Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Microtubule Cytoskeleton Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Microtubule-based Process Regulation Of Protein Metabolic Process Negative Regulation Of DNA Binding Cell Death Death Regulation Of Centrosome Cycle Centrosome Cycle Positive Regulation Of Histone H4-K20 Methylation Negative Regulation Of Centriole-centriole Cohesion Positive Regulation Of Histone H4-K16 Acetylation Fetal Process Involved In Parturition Regulation Of Translational Initiation Regulation Of JUN Kinase Activity Skeletal Muscle Cell Proliferation Positive Regulation Of Histone H3-K9 Acetylation Regulation Of Chromosome Segregation Cell Cycle Regulation Of DNA Binding Embryo Development Ending In Birth Or Egg Hatching Negative Regulation Of Binding Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Regulation Of Centriole-centriole Cohesion Microtubule Cytoskeleton Organization Negative Regulation Of Cell Cycle Apoptotic Process Cellular Response To Indole-3-methanol Regulation Of Mitotic Centrosome Separation Programmed Cell Death Regulation Of Cell Cycle Process Developmental Process Ribosomal Protein Import Into Nucleus Intraciliary Transport Involved In Cilium Morphogenesis Negative Regulation Of Centriole Replication Response To Cortisol Thymidine Metabolic Process Cell Cycle Process Regulation Of Cytoskeleton Organization Response To Ionizing Radiation Dosage Compensation By Inactivation Of X Chromosome Deoxyribonucleoside Monophosphate Biosynthetic Process Protein K6-linked Ubiquitination Regulation Of JNK Cascade Negative Regulation Of Cytoskeleton Organization	Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Catabolic Process Regulation Of Cellular Protein Metabolic Process Aromatic Compound Catabolic Process Cellular Macromolecule Catabolic Process Negative Regulation Of Cellular Metabolic Process Translational Initiation Regulation Of Protein Metabolic Process MRNA Metabolic Process Viral Process Nuclear-transcribed MRNA Poly(A) Tail Shortening Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Posttranscriptional Regulation Of Gene Expression Cell Surface Receptor Signaling Pathway Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Protein Catabolic Process Amyloid Precursor Protein Catabolic Process Regulation Of Translation MRNA 3'-end Processing Cellular Response To Organic Substance Viral Transcription Regulation Of Proteolysis Translation SRP-dependent Cotranslational Protein Targeting To Membrane Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum RNA 3'-end Processing Negative Regulation Of Catalytic Activity Protein Localization To Membrane Positive Regulation Of Cell Growth Beta-amyloid Metabolic Process Amyloid Precursor Protein Metabolic Process Protein Transport Regulation Of Protein Catabolic Process Protein Localization To Endoplasmic Reticulum Establishment Of Protein Localization Cellular Metabolic Process Membrane Protein Ectodomain Proteolysis Notch Receptor Processing Translational Termination Negative Regulation Of Apoptotic Process Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Catabolic Process
Tagcloud ?		4f adult biogenesis confer deprivation differed differs eif4f eif4g1 fetal gestation helicase hepatocyte insensitive liver nutrient oligopyrimidine preinitiation rapamycin refeeding ribosome sensing top tracts translation weights went	classes constituents cycling cyclins dexd dysregulation eif4a eif4a1 eif4b eif4e helicase helicases impede mcf7 microrna motors oncogenic otherwise pcdc4 polysome preferential quadruplexes ribosome structured translatome ubiquitous unwind unwinding utrs
Tagcloud (Difference) ?		4f adult biogenesis confer deprivation differed differs eif4f eif4g1 fetal gestation hepatocyte insensitive liver nutrient oligopyrimidine preinitiation rapamycin refeeding sensing top tracts translation weights went	classes constituents cycling cyclins dexd dysregulation eif4b eif4e helicases impede mcf7 microrna motors oncogenic otherwise pcdc4 polysome preferential quadruplexes structured translatome ubiquitous unwind unwinding utrs
Tagcloud (Intersection) ?		eif4a eif4a1 helicase ribosome