EIF4A2 and IPO11

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		EIF4A2	IPO11
Gene Name		eukaryotic translation initiation factor 4A2	importin 11
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 4F Complex Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm
	Molecular Function	Translation Initiation Factor Activity Helicase Activity Protein Binding ATP Binding ATPase Activity Poly(A) RNA Binding	Ran GTPase Binding Protein Transporter Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Viral Process Cytokine-mediated Signaling Pathway Cellular Protein Metabolic Process Negative Regulation Of RNA-directed RNA Polymerase Activity	Ribosomal Protein Import Into Nucleus
Pathways		Translation initiation complex formation Translation Deadenylation of mRNA ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system L13a-mediated translational silencing of Ceruloplasmin expression Antiviral mechanism by IFN-stimulated genes Deadenylation-dependent mRNA decay Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Cap-dependent Translation Initiation
Drugs
Diseases
GWAS			Alcohol and nictotine co-dependence ( 23216389)
Protein-Protein Interactions		17 interactors: BRCA1 CLNS1A DPPA4 ECT2 EIF4G1 EIF4G2 IPO11 MDFI NEK2 PDCD4 PFDN1 PIH1D2 SLC16A9 SSX2IP TK1 TRIM36 TRIM39	11 interactors: C1orf94 EIF4A2 KEAP1 NXF1 PLCD4 RAN RPL12 TRAF2 UBE2E1 UBE2E2 UBE2E3
Entrez ID		1974	51194
HPRD ID		03062	10003
Ensembl ID		ENSG00000156976	ENSG00000086200
Uniprot IDs		Q14240 Q9NZE6	Q9UI26
PDB IDs		3BOR
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Centrosome Organization Microtubule Organizing Center Organization Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Microtubule Cytoskeleton Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Microtubule-based Process Regulation Of Protein Metabolic Process Negative Regulation Of DNA Binding Cell Death Death Regulation Of Centrosome Cycle Centrosome Cycle Positive Regulation Of Histone H4-K20 Methylation Negative Regulation Of Centriole-centriole Cohesion Positive Regulation Of Histone H4-K16 Acetylation Fetal Process Involved In Parturition Regulation Of Translational Initiation Regulation Of JUN Kinase Activity Skeletal Muscle Cell Proliferation Positive Regulation Of Histone H3-K9 Acetylation Regulation Of Chromosome Segregation Cell Cycle Regulation Of DNA Binding Embryo Development Ending In Birth Or Egg Hatching Negative Regulation Of Binding Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Regulation Of Centriole-centriole Cohesion Microtubule Cytoskeleton Organization Negative Regulation Of Cell Cycle Apoptotic Process Cellular Response To Indole-3-methanol Regulation Of Mitotic Centrosome Separation Programmed Cell Death Regulation Of Cell Cycle Process Developmental Process Ribosomal Protein Import Into Nucleus Intraciliary Transport Involved In Cilium Morphogenesis Negative Regulation Of Centriole Replication Response To Cortisol Thymidine Metabolic Process Cell Cycle Process Regulation Of Cytoskeleton Organization Response To Ionizing Radiation Dosage Compensation By Inactivation Of X Chromosome Deoxyribonucleoside Monophosphate Biosynthetic Process Protein K6-linked Ubiquitination Regulation Of JNK Cascade Negative Regulation Of Cytoskeleton Organization	Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation ISG15-protein Conjugation Catabolic Process Protein K11-linked Ubiquitination Viral Process Cellular Response To Cytokine Stimulus Response To Cytokine Positive Regulation Of Proteolysis Cellular Macromolecule Catabolic Process Positive Regulation Of Protein Binding Negative Regulation Of RNA-directed RNA Polymerase Activity Cellular Protein Metabolic Process Cytokine-mediated Signaling Pathway Nuclear Export Positive Regulation Of Binding Ribosomal Small Subunit Export From Nucleus Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Proteasomal Ubiquitin-independent Protein Catabolic Process Regulation Of Protein Binding Nuclear-transcribed MRNA Catabolic Process Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process MRNA Catabolic Process Protein Metabolic Process Regulation Of Proteolysis Cytoplasmic Transport RNA Catabolic Process Negative Regulation Of Glial Cell Apoptotic Process Viral Life Cycle Cellular Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Ribosomal Large Subunit Export From Nucleus Histone H2B Ubiquitination Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Ribosomal Subunit Export From Nucleus Poly(A)+ MRNA Export From Nucleus Regulation Of Cell Cycle Phase Transition Translational Initiation Positive Regulation Of Protein Homodimerization Activity Metabolic Process Cellular Response To Nitric Oxide Nucleocytoplasmic Transport Proteasomal Protein Catabolic Process Regulation Of Binding
Tagcloud ?		4f adult biogenesis confer deprivation differed differs eif4f eif4g1 fetal gestation helicase hepatocyte insensitive liver nutrient oligopyrimidine preinitiation rapamycin refeeding ribosome sensing top tracts translation weights went
Tagcloud (Difference) ?		4f adult biogenesis confer deprivation differed differs eif4f eif4g1 fetal gestation helicase hepatocyte insensitive liver nutrient oligopyrimidine preinitiation rapamycin refeeding ribosome sensing top tracts translation weights went
Tagcloud (Intersection) ?