EFNA3 and EPHA3

Number of citations of the paper that reports this interaction (PMID 9195962)
16

Data Source:
BioGRID (pull down)

		EFNA3	EPHA3
Gene Name		ephrin-A3	EPH receptor A3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Anchored Component Of Membrane	Extracellular Region Early Endosome Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Transmembrane-ephrin Receptor Activity Ephrin Receptor Binding	GPI-linked Ephrin Receptor Activity Protein Binding ATP Binding
	Biological Process	Cell-cell Signaling Axon Guidance Ephrin Receptor Signaling Pathway	Cell Adhesion Axon Guidance Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Neuron Projection Development Cell Migration Peptidyl-tyrosine Phosphorylation Regulation Of Rho GTPase Activity Regulation Of Actin Cytoskeleton Organization Ephrin Receptor Signaling Pathway Regulation Of Focal Adhesion Assembly Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Retinoic Acid Fasciculation Of Sensory Neuron Axon Fasciculation Of Motor Neuron Axon
Pathways		EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling	EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)	Orofacial clefts ( 22863734)
Protein-Protein Interactions		9 interactors: EPHA2 EPHA3 EPHA4 EPHA5 EPHA7 KRTAP10-3 MEOX2 NOTCH2NL PRSS23	20 interactors: ABL1 ADAM10 CDKN2A CRK EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EFNB1 EFNB2 FYN PIM1 RBM18 RUFY1 RUFY2 SRC SRPK1 STAT3 TP53
Entrez ID		1944	2042
HPRD ID		03225	01555
Ensembl ID		ENSG00000143590	ENSG00000044524
Uniprot IDs		B7ZAD3 P52797	C9JXA2 P29320 Q6P4R6
PDB IDs			2GSF 2QO2 2QO7 2QO9 2QOB 2QOC 2QOD 2QOF 2QOI 2QOK 2QOL 2QON 2QOO 2QOQ 3DZQ 3FXX 3FY2 4G2F 4GK2 4GK3 4GK4
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Axon Guidance Fasciculation Of Motor Neuron Axon Fasciculation Of Sensory Neuron Axon Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Rho GTPase Activity Cell Morphogenesis Involved In Differentiation Neuron Projection Development Regulation Of Rho Protein Signal Transduction Cell Projection Morphogenesis Cell Part Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-amino Acid Modification Neuron Development Cell Morphogenesis Neuron Differentiation Cell Projection Organization Regulation Of Rac GTPase Activity Regulation Of Ras GTPase Activity Locomotion Axonal Fasciculation Protein Phosphorylation Anatomical Structure Morphogenesis Regulation Of Ras Protein Signal Transduction Movement Of Cell Or Subcellular Component Regulation Of Rac Protein Signal Transduction Neuron Recognition Generation Of Neurons Regulation Of Small GTPase Mediated Signal Transduction Regulation Of GTPase Activity Neurogenesis Multicellular Organismal Development Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Cell Development Response To External Stimulus Phosphorylation Cell Differentiation Developmental Process Positive Regulation Of Rho Guanyl-nucleotide Exchange Factor Activity Notochord Cell Development Nervous System Development Regulation Of Cell Projection Organization Regulation Of Catalytic Activity	Ephrin Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuron Differentiation Neuron Projection Development Cell Projection Morphogenesis Generation Of Neurons Cell Part Morphogenesis Neurogenesis Neuron Development Cell Development Cell Morphogenesis Movement Of Cell Or Subcellular Component Cell Projection Organization Locomotion Nervous System Development Response To External Stimulus Anatomical Structure Morphogenesis Cell Surface Receptor Signaling Pathway Cell Differentiation Signal Transduction Developmental Process Regulation Of Cell Adhesion Signaling Cell Communication Cellular Response To Stimulus Positive Regulation Of Protein Modification Process Phosphorylation Multicellular Organismal Development Regulation Of Cell-cell Adhesion Regulation Of Cellular Component Organization Anatomical Structure Development Regulation Of Cell Proliferation Regulation Of Protein Phosphorylation System Development Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Peptidyl-tyrosine Phosphorylation Positive Regulation Of Signal Transduction Positive Regulation Of Cell Cycle Positive Regulation Of Phosphorylation
Tagcloud ?		a2780 a2780mtp53 adamts1 affymetrix angiogenesis angiogenic angiopoietin arrays b4 confirmation constituents ecm efnb2 endoglin ephrin exploratory fgf20 hypoxic integral ionizing metalloproteinase microenvironment mmp10 mtp53 tp53 u133a upregulated vegfa wttp53	arid2 asxl3 cdkn2a clonal clone dipyrimidine driver extension founding geographic hypermutator lacked mel9 melanoma mll2 nras phosphatases ptprb ptprd ptprt rb1 signature strikingly subclonal subclones suppressors transitions truncation wgs
Tagcloud (Difference) ?		a2780 a2780mtp53 adamts1 affymetrix angiogenesis angiogenic angiopoietin arrays b4 confirmation constituents ecm efnb2 endoglin ephrin exploratory fgf20 hypoxic integral ionizing metalloproteinase microenvironment mmp10 mtp53 tp53 u133a upregulated vegfa wttp53	arid2 asxl3 cdkn2a clonal clone dipyrimidine driver extension founding geographic hypermutator lacked mel9 melanoma mll2 nras phosphatases ptprb ptprd ptprt rb1 signature strikingly subclonal subclones suppressors transitions truncation wgs
Tagcloud (Intersection) ?