EFNA3 and EPHA7

Number of citations of the paper that reports this interaction (PMID 10366629)
16

Data Source:
HPRD (in vivo)

		EFNA3	EPHA7
Gene Name		ephrin-A3	EPH receptor A7
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Anchored Component Of Membrane	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Neuromuscular Junction Neuronal Cell Body Postsynaptic Membrane
	Molecular Function	Transmembrane-ephrin Receptor Activity Ephrin Receptor Binding	Protein Tyrosine Kinase Activity GPI-linked Ephrin Receptor Activity Protein Binding ATP Binding Axon Guidance Receptor Activity Chemorepellent Activity Ephrin Receptor Binding
	Biological Process	Cell-cell Signaling Axon Guidance Ephrin Receptor Signaling Pathway	Axon Guidance Brain Development Phosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of Cell-cell Adhesion Retinal Ganglion Cell Axon Guidance Regulation Of Protein Autophosphorylation Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Ephrin Receptor Signaling Pathway Branching Morphogenesis Of A Nerve Regulation Of Peptidyl-tyrosine Phosphorylation Negative Chemotaxis Regulation Of ERK1 And ERK2 Cascade
Pathways		EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling	EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)	Dialysis-related mortality ( 21546767) Response to hepatitis C treatment ( 22095909)
Protein-Protein Interactions		9 interactors: EPHA2 EPHA3 EPHA4 EPHA5 EPHA7 KRTAP10-3 MEOX2 NOTCH2NL PRSS23	8 interactors: EFNA1 EFNA3 EFNA4 EFNA5 GNB1 MAP1LC3A MLLT4 ZNF267
Entrez ID		1944	2045
HPRD ID		03225	03721
Ensembl ID		ENSG00000143590	ENSG00000135333
Uniprot IDs		B7ZAD3 P52797	Q15375
PDB IDs			2REI 3DKO 3H8M 3NRU
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Axon Guidance Fasciculation Of Motor Neuron Axon Fasciculation Of Sensory Neuron Axon Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Rho GTPase Activity Cell Morphogenesis Involved In Differentiation Neuron Projection Development Regulation Of Rho Protein Signal Transduction Cell Projection Morphogenesis Cell Part Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-amino Acid Modification Neuron Development Cell Morphogenesis Neuron Differentiation Cell Projection Organization Regulation Of Rac GTPase Activity Regulation Of Ras GTPase Activity Locomotion Axonal Fasciculation Protein Phosphorylation Anatomical Structure Morphogenesis Regulation Of Ras Protein Signal Transduction Movement Of Cell Or Subcellular Component Regulation Of Rac Protein Signal Transduction Neuron Recognition Generation Of Neurons Regulation Of Small GTPase Mediated Signal Transduction Regulation Of GTPase Activity Neurogenesis Multicellular Organismal Development Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Cell Development Response To External Stimulus Phosphorylation Cell Differentiation Developmental Process Positive Regulation Of Rho Guanyl-nucleotide Exchange Factor Activity Notochord Cell Development Nervous System Development Regulation Of Cell Projection Organization Regulation Of Catalytic Activity	Ephrin Receptor Signaling Pathway Cell-cell Signaling Axon Guidance Response To External Stimulus Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Cell Development Enzyme Linked Receptor Protein Signaling Pathway Neuron Development Developmental Process Cell Morphogenesis Neuron Differentiation Cell Communication Cell Projection Organization Locomotion Cellular Response To Stimulus Movement Of Cell Or Subcellular Component Negative Regulation Of Dendritic Spine Morphogenesis Generation Of Neurons Positive Regulation Of Peptidyl-tyrosine Phosphorylation Multicellular Organismal Development Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Neurogenesis Anatomical Structure Development Cell Surface Receptor Signaling Pathway Aortic Valve Morphogenesis Endocardial Cushion To Mesenchymal Transition Notochord Formation Mitral Valve Morphogenesis Negative Regulation Of Dendritic Spine Development Signal Transduction Regulation Of Peptidyl-tyrosine Phosphorylation Mitral Valve Development Establishment Of Endothelial Intestinal Barrier Cardiac Muscle Cell Apoptotic Process Cell Differentiation Muscle Cell Apoptotic Process Negative Regulation Of Dendrite Morphogenesis Signaling Response To Stimulus Peptidyl-tyrosine Phosphorylation Notochord Morphogenesis
Tagcloud ?		a2780 a2780mtp53 adamts1 affymetrix angiogenesis angiogenic angiopoietin arrays b4 confirmation constituents ecm efnb2 endoglin ephrin exploratory fgf20 hypoxic integral ionizing metalloproteinase microenvironment mmp10 mtp53 tp53 u133a upregulated vegfa wttp53	aberrations additional advances approaches biological closely contribute crebbp ep300 expected ezh2 fl follicular genetic hallmark hand individuals lymphoma mef2b microenvironment mll2 pathogenesis recognized recurrent technology tnfrsf14 translocation understanding unique
Tagcloud (Difference) ?		a2780 a2780mtp53 adamts1 affymetrix angiogenesis angiogenic angiopoietin arrays b4 confirmation constituents ecm efnb2 endoglin ephrin exploratory fgf20 hypoxic integral ionizing metalloproteinase mmp10 mtp53 tp53 u133a upregulated vegfa wttp53	aberrations additional advances approaches biological closely contribute crebbp ep300 expected ezh2 fl follicular genetic hallmark hand individuals lymphoma mef2b mll2 pathogenesis recognized recurrent technology tnfrsf14 translocation understanding unique
Tagcloud (Intersection) ?		microenvironment