EDN1 and ADM

Number of citations of the paper that reports this interaction (PMID 11410113)
0

Data Source:
HPRD (in vivo)

		EDN1	ADM
Gene Name		endothelin 1	adrenomedullin
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Weibel-Palade Body Basal Part Of Cell Rough Endoplasmic Reticulum Lumen	Extracellular Region Extracellular Space Cytoplasm
	Molecular Function	Cytokine Activity Hormone Activity Protein Binding Endothelin A Receptor Binding Endothelin B Receptor Binding	Receptor Binding Hormone Activity Protein Binding Adrenomedullin Receptor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Prostaglandin Biosynthetic Process Patterning Of Blood Vessels In Utero Embryonic Development Histamine Secretion Regulation Of Systemic Arterial Blood Pressure By Endothelin Regulation Of PH Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Heart Development Respiratory Gaseous Exchange Body Fluid Secretion Positive Regulation Of Cell Proliferation Dorsal/ventral Pattern Formation Response To Ozone Multicellular Organismal Aging Positive Regulation Of Heart Rate Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Receptor Biosynthetic Process Neural Crest Cell Development Phosphatidylinositol 3-kinase Signaling Response To Activity Artery Smooth Muscle Contraction Vein Smooth Muscle Contraction Glucose Transport Cell Growth Regulation Of Vasoconstriction Sensory Perception Of Pain Calcium-mediated Signaling Peptide Hormone Secretion Nitric Oxide Transport Negative Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Neutrophil Chemotaxis Negative Regulation Of CAMP Biosynthetic Process Phospholipase D-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Prostaglandin Secretion Response To Lipopolysaccharide Response To Testosterone Negative Regulation Of Smooth Muscle Cell Apoptotic Process Response To Prostaglandin F Response To Nicotine Cellular Response To Drug Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Response To Muscle Stretch Epithelial Fluid Transport Vasoconstriction Protein Kinase C Deactivation Middle Ear Morphogenesis Positive Regulation Of Odontogenesis Superoxide Anion Generation Rhythmic Excitation Response To Amino Acid Positive Regulation Of MAP Kinase Activity Positive Regulation Of JUN Kinase Activity Response To Leptin Leukocyte Activation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Cell Size Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Hormone Secretion Negative Regulation Of Hormone Secretion Inositol Phosphate-mediated Signaling Positive Regulation Of Smooth Muscle Cell Proliferation Cartilage Development Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process Membrane Depolarization Regulation Of Sensory Perception Of Pain Maternal Process Involved In Parturition Positive Regulation Of Sarcomere Organization Positive Regulation Of Prostaglandin-endoperoxide Synthase Activity Positive Regulation Of Chemokine-mediated Signaling Pathway Cellular Response To Calcium Ion Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Peptide Hormone Stimulus Cellular Response To Glucocorticoid Stimulus Cellular Response To Mineralocorticoid Stimulus Cellular Response To Fatty Acid Cellular Response To Hypoxia Response To Dexamethasone Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Neutrophil Chemotaxis Response To Salt	Vasculogenesis Response To Hypoxia Neural Tube Closure Regulation Of The Force Of Heart Contraction G-protein Coupled Receptor Internalization CAMP Biosynthetic Process Progesterone Biosynthetic Process Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Heart Development Female Pregnancy Aging Blood Circulation Androgen Metabolic Process Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Response To Cold Response To Wounding Positive Regulation Of Heart Rate CAMP-mediated Signaling Positive Regulation Of CAMP Biosynthetic Process Organ Regeneration Neuron Projection Regeneration Receptor Internalization Response To Lipopolysaccharide Response To Insulin Odontogenesis Of Dentin-containing Tooth Response To Starvation Positive Regulation Of Apoptotic Process Negative Regulation Of Vascular Permeability Positive Regulation Of Angiogenesis Negative Regulation Of Vasoconstriction Positive Regulation Of Vasodilation Hormone Secretion Developmental Growth Response To Glucocorticoid Branching Involved In Labyrinthine Layer Morphogenesis Spongiotrophoblast Layer Development Vascular Smooth Muscle Cell Development Positive Regulation Of Vasculogenesis
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Calcitonin-like ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Circulating vasoactive peptide levels ( 23381795)	Blood pressure ( 21909110) Circulating vasoactive peptide levels ( 23381795) Diastolic blood pressure ( 21909115) HDL cholesterol ( 20686565) Schizophrenia, bipolar disorder and depression (combined) ( 20713499) Systolic blood pressure ( 21909115)
Protein-Protein Interactions		10 interactors: ADM BAG6 CMA1 COPS6 ECE1 EDNRA EDNRB KEL MME UBQLN4	4 interactors: CALCRL CFH EDN1 MME
Entrez ID		1906	133
HPRD ID		07030	00061
Ensembl ID		ENSG00000078401
Uniprot IDs		P05305 Q6FH53	P35318
PDB IDs		1EDN 1EDP 1T7H 1V6R	2FLY 2L7S
Enriched GO Terms of Interacting Partners?		Blood Circulation Regulation Of Blood Pressure Regulation Of Angiotensin Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Endothelin Receptor Signaling Pathway Vasoconstriction Peptide Hormone Processing Hormone Metabolic Process Cellular Chemical Homeostasis Organ Development Regulation Of Hormone Levels Regulation Of Blood Vessel Size Regulation Of Tube Size Cellular Calcium Ion Homeostasis Cellular Homeostasis Calcium Ion Homeostasis Regulation Of Protein Metabolic Process Sensory Perception Of Pain Regulation Of CAMP Biosynthetic Process Aging Regulation Of Systemic Arterial Blood Pressure Angiotensin Maturation Regulation Of CAMP Metabolic Process Enteric Nervous System Development Chemical Homeostasis Vascular Smooth Muscle Contraction Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Peptide Metabolic Process Metal Ion Homeostasis System Development Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Homeostasis Ion Homeostasis Negative Regulation Of CAMP Biosynthetic Process Cyclic-nucleotide-mediated Signaling Negative Regulation Of CAMP Metabolic Process Multicellular Organismal Development Anatomical Structure Development Protein Processing Nervous System Development Negative Regulation Of Nucleotide Metabolic Process Homeostatic Process Cellular Amide Metabolic Process Tube Development Autonomic Nervous System Development Regulation Of Inflammatory Response Proteolysis	Positive Regulation Of Smooth Muscle Cell Proliferation Sensory Perception Of Pain Regulation Of CAMP Biosynthetic Process Regulation Of Systemic Arterial Blood Pressure Regulation Of CAMP Metabolic Process Regulation Of Smooth Muscle Cell Proliferation Phospholipase D-activating G-protein Coupled Receptor Signaling Pathway Cellular Response To Sucrose Stimulus Protein Kinase C Deactivation Regulation Of Muscle Contraction Cellular Response To Mineralocorticoid Stimulus Response To Salt Rhythmic Excitation Regulation Of Blood Pressure Cellular Response To UV-A Nitric Oxide Transport Response To Prostaglandin F Positive Regulation Of Chemokine-mediated Signaling Pathway Positive Regulation Of Prostaglandin-endoperoxide Synthase Activity Vein Smooth Muscle Contraction Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process Regulation Of Hormone Levels Regulation Of Systemic Arterial Blood Pressure By Endothelin Epithelial Fluid Transport Creatinine Metabolic Process Regulation Of Inflammatory Response Positive Regulation Of Sarcomere Organization Rhythmic Synaptic Transmission Response To UV-A Blood Circulation Response To Ozone Negative Regulation Of Smooth Muscle Cell Apoptotic Process Aging Angiogenesis Cellular Response To UV-B Artery Smooth Muscle Contraction Response To Muscle Stretch Tonic Smooth Muscle Contraction Maternal Process Involved In Parturition Positive Regulation Of Receptor Biosynthetic Process Positive Regulation Of Odontogenesis Angiotensin Maturation Cellular Response To Organic Substance Blood Vessel Morphogenesis Regulation Of Angiotensin Metabolic Process Complement Activation, Alternative Pathway Positive Regulation Of Renal Sodium Excretion Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Positive Regulation Of Prostaglandin Secretion
Tagcloud ?		19q13 6p23 ankyloglossia bcl3 causation cleft disequilibrium exemplify indictment inheritance lip malformation mendelian merely monogenic multigenic nurture orofacial palatal palate parametric pedigrees penetrance recognised rests syndromic tentative teratogenic teratogens	7mg adriamycin cap cddp clinic cpm cr cyclophosphamide d1 d10 divided home hrs infusion nausea nephrotoxicities ns outpatient ovarian pr remarkably saline schedule schedules side sqm suitable twenty vomiting
Tagcloud (Difference) ?		19q13 6p23 ankyloglossia bcl3 causation cleft disequilibrium exemplify indictment inheritance lip malformation mendelian merely monogenic multigenic nurture orofacial palatal palate parametric pedigrees penetrance recognised rests syndromic tentative teratogenic teratogens	7mg adriamycin cap cddp clinic cpm cr cyclophosphamide d1 d10 divided home hrs infusion nausea nephrotoxicities ns outpatient ovarian pr remarkably saline schedule schedules side sqm suitable twenty vomiting
Tagcloud (Intersection) ?