S1PR3 and GNAI1

Number of citations of the paper that reports this interaction (PMID 10488065)
54

Data Source:
HPRD (in vitro)

		S1PR3	GNAI1
Gene Name		sphingosine-1-phosphate receptor 3	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Nucleus Cytoplasm Lysosomal Membrane Centrosome Heterotrimeric G-protein Complex Plasma Membrane Midbody Extracellular Vesicular Exosome
	Molecular Function	G-protein Coupled Receptor Activity Integrin Binding Lipid Binding Sphingosine-1-phosphate Receptor Activity	GTPase Activity Signal Transducer Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding G-protein Coupled Serotonin Receptor Binding Metal Ion Binding
	Biological Process	Cytokine Production Sphingosine-1-phosphate Signaling Pathway Inflammatory Response G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Proliferation Anatomical Structure Morphogenesis Regulation Of Interleukin-1 Beta Production Negative Regulation Of Establishment Of Endothelial Barrier	Cell Cycle G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Blood Coagulation Platelet Activation Response To Peptide Hormone Cell Division
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Lysosphingolipid and LPA receptors	Signaling by GPCR Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Signal amplification G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 GABA B receptor activation Adenylate cyclase inhibitory pathway GABA receptor activation PLC beta mediated events Opioid Signalling Regulation of insulin secretion G-protein mediated events Adrenaline,noradrenaline inhibits insulin secretion Inhibition of adenylate cyclase pathway Adenylate cyclase inhibitory pathway GPCR downstream signaling G-protein activation Platelet activation, signaling and aggregation Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Response to statin therapy (LDL-C) ( 22331829)
Protein-Protein Interactions		4 interactors: GNA13 GNAI1 GNAQ HTR1A	57 interactors: ADCY5 ADRA2A CCR5 CD47 CNR1 CRHR1 CXCR4 DRD3 EPOR ESR1 FFAR1 GNAO1 GNB2 GNB4 GPR1 GPR143 GPSM1 GPSM2 GPSM3 HRH4 HTR2A IGF1R KLHL3 MTNR1A MTNR1B NGB NUCB1 NUMA1 OPRD1 OPRM1 PDE6D PTPRU RANGAP1 RASD1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS20 RGS4 RGS7 RIC8A S1PR1 S1PR2 S1PR3 S1PR4 S1PR5 SSTR2 SSTR3 STRN THAP7 TSHR VIPR1 WASF1
Entrez ID		1903	2770
HPRD ID		03572	00756
Ensembl ID		ENSG00000213694	ENSG00000127955
Uniprot IDs		Q99500	P63096
PDB IDs			1KJY 1Y3A 2G83 2GTP 2IK8 2OM2 2PZ3 2XNS 3ONW 3QE0 3QI2 3UMR 3UMS 4G5Q
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Platelet Activation G-protein Coupled Receptor Signaling Pathway Blood Coagulation Hemostasis Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of Body Fluid Levels Positive Regulation Of Phospholipase Activity Wound Healing Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Cell Activation Response To Wounding Cell Surface Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Response To Stress Regulation Of Serotonin Secretion Phospholipase C-activating Dopamine Receptor Signaling Pathway Neuron Remodeling Regulation Of Melanocyte Differentiation Serotonin Metabolic Process Serotonin Receptor Signaling Pathway Signal Transduction Activation Of Phospholipase D Activity Maternal Behavior Regulation Of Dopamine Metabolic Process Signaling Cell Communication Behavior Regulation Of Catenin Import Into Nucleus Regulation Of Developmental Pigmentation Exploration Behavior Neuron Maturation Vasoconstriction Dopamine Receptor Signaling Pathway Behavioral Fear Response Cellular Response To Stimulus Forebrain Neuron Development Fear Response Cardiovascular System Development Patterning Of Blood Vessels Activation Of Phospholipase C Activity Vesicle Fusion Positive Regulation Of Phospholipase C Activity Rho Protein Signal Transduction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Forebrain Neuron Differentiation Glutamate Receptor Signaling Pathway	G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Surface Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Signal Transduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Signaling Cell Communication Regulation Of Catalytic Activity Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Cellular Response To Stimulus Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Response To Stimulus Regulation Of Signaling Positive Regulation Of Hydrolase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Sphingosine-1-phosphate Signaling Pathway Regulation Of Cellular Process Chemical Homeostasis Cell-cell Signaling Cytosolic Calcium Ion Homeostasis Positive Regulation Of GTPase Activity Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Synaptic Transmission Negative Regulation Of Signaling Behavior Cellular Metal Ion Homeostasis Neuropeptide Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Cellular Cation Homeostasis Ion Homeostasis Cellular Ion Homeostasis Homeostatic Process Metal Ion Homeostasis Negative Regulation Of Signal Transduction Cellular Chemical Homeostasis Locomotory Behavior Response To Ammonium Ion Negative Regulation Of Ion Transport Response To Cocaine Regulation Of Cell Proliferation Neurological System Process
Tagcloud ?		acetyl albumin alleviates ao bsa circulation equivalent excretion fty720 glucosaminidase gradually immunomodulatory infiltration ip killed mcp monocytes nephrectomy nephropathy overload reached s1pr1 saline sphingosine sphk1 synthesizing tubulointerstitium wistar	alkenes azotic constructions gnao1 heterocycle hm hms htr1b htr2a htr2b htr4 htr6 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkcd prkce prkcg prkd1 propertied pubchem rock2 rps6ka1 rps6ka3 tlr8 tradition
Tagcloud (Difference) ?		acetyl albumin alleviates ao bsa circulation equivalent excretion fty720 glucosaminidase gradually immunomodulatory infiltration ip killed mcp monocytes nephrectomy nephropathy overload reached s1pr1 saline sphingosine sphk1 synthesizing tubulointerstitium wistar	alkenes azotic constructions gnao1 heterocycle hm hms htr1b htr2a htr2b htr4 htr6 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkcd prkce prkcg prkd1 propertied pubchem rock2 rps6ka1 rps6ka3 tlr8 tradition
Tagcloud (Intersection) ?