E2F6 and BMI1

Number of citations of the paper that reports this interaction (PMID 11171983)
70

Data Source:
HPRD (in vivo)

		E2F6	BMI1
Gene Name		E2F transcription factor 6	BMI1 proto-oncogene, polycomb ring finger
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex MLL1 Complex	Ubiquitin Ligase Complex Heterochromatin Nucleus Nucleoplasm Cytoplasm Nuclear Body PcG Protein Complex PRC1 Complex
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding RING-like Zinc Finger Domain Binding
	Biological Process	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development DNA Methylation Transcription, DNA-templated Humoral Immune Response Segment Specification Brain Development Regulation Of Gene Expression Histone Acetylation Histone Ubiquitination Rostrocaudal Neural Tube Patterning Hemopoiesis Positive Regulation Of B Cell Proliferation Positive Regulation Of Immature T Cell Proliferation In Thymus Somatic Stem Cell Division Positive Regulation Of Fibroblast Proliferation Embryonic Skeletal System Morphogenesis Positive Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Apoptotic Signaling Pathway
Pathways			Oxidative Stress Induced Senescence Cellular Senescence
Drugs
Diseases
GWAS		Sudden cardiac arrest ( 21658281)
Protein-Protein Interactions		14 interactors: APP ARAF BMI1 E2F1 EPC1 EZH1 EZH2 KRTAP10-7 PCGF6 RING1 RYBP TFDP1 TFDP2 ZMYND11	35 interactors: CBX6 CBX7 CBX8 CSNK2B E2F6 FOXS1 H2AFX HIST2H2AA3 HIST2H2AC HIST3H3 IMMT KAT5 KIAA1377 KMT2A LRIF1 MAPK14 NDEL1 PCGF3 PCGF6 PHC1 PHC2 PTN RING1 RNF114 RNF2 RRM1 SOCS2 TRIM27 TUSC3 UBE2D3 UBE2I USP11 USP7 VPS11 ZBTB16
Entrez ID		1876	648
HPRD ID		04251	01277
Ensembl ID		ENSG00000169016	ENSG00000168283
Uniprot IDs		G5E936 O75461 Q53YM3 Q6Q9Z5 Q6Q9Z6	P35226
PDB IDs			2H0D 3RPG
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Chromatin Modification Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Histone Modification Nucleobase-containing Compound Metabolic Process Chromatin Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Chromosome Organization Histone Ubiquitination Notch Signaling Pathway Biosynthetic Process Anoikis Peptidyl-lysine Modification Histone H3-K27 Methylation Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Histone H2A Monoubiquitination Histone H2A Ubiquitination Histone Monoubiquitination Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Cellular Protein Modification Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Cellular Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Transcription Elongation From RNA Polymerase II Promoter Regulation Of Gene Expression, Epigenetic	Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Ubiquitination Negative Regulation Of Transcription From RNA Polymerase II Promoter Protein Modification By Small Protein Conjugation Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Transcription, DNA-templated Chromatin Organization RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization Chromatin Modification Histone Ubiquitination Cellular Macromolecule Biosynthetic Process Cellular Protein Modification Process Negative Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Histone Modification Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Organelle Organization Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Metabolic Process Protein Monoubiquitination Proteasomal Protein Catabolic Process Biosynthetic Process Cellular Protein Metabolic Process Regulation Of Gene Expression Response To Ionizing Radiation Mitotic Cell Cycle Cell Cycle Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Histone H2A Monoubiquitination Histone H2A Ubiquitination Protein Metabolic Process Negative Regulation Of Interleukin-2 Production Histone Monoubiquitination
Tagcloud ?		193a accumulating alters attenuate bimodal cd117 cd44 chemoresistance competition complexity conjecture constitute dataset experimentally initiating kit mathematical microrna namely ocic ovarian persistence picture polycomb predicts switching tcga unravel ways	activators coimmunoprecipitate colocalize combs drosophila eed enhancer enx1 esc example extra ezh2 homolog homology hpc2 hybrid interacts melanogaster osteosarcoma pcg polycomb progeny repressors screen trithorax trxg unlike z zeste
Tagcloud (Difference) ?		193a accumulating alters attenuate bimodal cd117 cd44 chemoresistance competition complexity conjecture constitute dataset experimentally initiating kit mathematical microrna namely ocic ovarian persistence picture predicts switching tcga unravel ways	activators coimmunoprecipitate colocalize combs drosophila eed enhancer enx1 esc example extra ezh2 homolog homology hpc2 hybrid interacts melanogaster osteosarcoma pcg progeny repressors screen trithorax trxg unlike z zeste
Tagcloud (Intersection) ?		polycomb