E2F6 and PCGF6

Number of citations of the paper that reports this interaction (PMID 11171983)
70

Data Source:
HPRD (in vitro)

		E2F6	PCGF6
Gene Name		E2F transcription factor 6	polycomb group ring finger 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex MLL1 Complex	Nucleus PcG Protein Complex PRC1 Complex
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Zinc Ion Binding
	Biological Process	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated
Pathways
Drugs
Diseases
GWAS		Sudden cardiac arrest ( 21658281)
Protein-Protein Interactions		14 interactors: APP ARAF BMI1 E2F1 EPC1 EZH1 EZH2 KRTAP10-7 PCGF6 RING1 RYBP TFDP1 TFDP2 ZMYND11	16 interactors: BMI1 CBX6 CBX7 CBX8 CDK7 E2F6 HIST3H3 KDM5D PEX10 RAD18 RING1 RNF2 SS18L1 UBE2U USP2 USP21
Entrez ID		1876	84108
HPRD ID		04251	07427
Ensembl ID		ENSG00000169016	ENSG00000156374
Uniprot IDs		G5E936 O75461 Q53YM3 Q6Q9Z5 Q6Q9Z6	Q9BYE7
PDB IDs			2DJB
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Chromatin Modification Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Histone Modification Nucleobase-containing Compound Metabolic Process Chromatin Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Chromosome Organization Histone Ubiquitination Notch Signaling Pathway Biosynthetic Process Anoikis Peptidyl-lysine Modification Histone H3-K27 Methylation Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Histone H2A Monoubiquitination Histone H2A Ubiquitination Histone Monoubiquitination Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Cellular Protein Modification Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Cellular Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Transcription Elongation From RNA Polymerase II Promoter Regulation Of Gene Expression, Epigenetic	Chromatin Modification Chromosome Organization Chromatin Organization Histone Ubiquitination Histone Modification Organelle Organization Negative Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Protein Ubiquitination Nitrogen Compound Metabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Cellular Protein Modification Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Histone H2A Monoubiquitination Macromolecule Biosynthetic Process Cellular Metabolic Process Histone H2A Ubiquitination Regulation Of Gene Expression Histone Monoubiquitination Cellular Protein Metabolic Process Biosynthetic Process Protein Monoubiquitination Regulation Of Metabolic Process DNA Metabolic Process Anterior/posterior Pattern Specification Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Metabolic Process Histone H2A-K119 Monoubiquitination Metabolic Process Positive Regulation Of Immature T Cell Proliferation In Thymus
Tagcloud ?		193a accumulating alters attenuate bimodal cd117 cd44 chemoresistance competition complexity conjecture constitute dataset experimentally initiating kit mathematical microrna namely ocic ovarian persistence picture polycomb predicts switching tcga unravel ways	attains cbx3 collaboration compacted copresence e2f6 e2fs entailing h2a hp1gamma integral l3mbtl1 l3mbtl2 marks mblr mbt monoubiquitination necessitated overlap polycomb prc1 prc1l4 rb1 repression repressive ring1 ring2 rnai
Tagcloud (Difference) ?		193a accumulating alters attenuate bimodal cd117 cd44 chemoresistance competition complexity conjecture constitute dataset experimentally initiating kit mathematical microrna namely ocic ovarian persistence picture predicts switching tcga unravel ways	attains cbx3 collaboration compacted copresence e2fs entailing h2a hp1gamma integral l3mbtl1 l3mbtl2 marks mblr mbt monoubiquitination necessitated overlap prc1 prc1l4 rb1 repression repressive ring1 ring2 rnai
Tagcloud (Intersection) ?		e2f6 polycomb