DYNC1I1 and DYNLRB1

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DYNC1I1	DYNLRB1
Gene Name		dynein, cytoplasmic 1, intermediate chain 1	dynein, light chain, roadblock-type 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Spindle Pole Cytosol Cytoplasmic Dynein Complex Microtubule Vesicle Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm Recycling Endosome	Cytoplasm Centrosome Cytoplasmic Dynein Complex Microtubule Membrane Primary Cilium Ciliary Tip
	Molecular Function	Motor Activity Microtubule Motor Activity Protein Binding Microtubule Binding Spectrin Binding	Microtubule Motor Activity
	Biological Process	Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Vesicle Transport Along Microtubule	Transport Organelle Organization Microtubule-based Movement Visual Behavior Metabolic Process
Pathways		MHC class II antigen presentation Adaptive Immune System	Organelle biogenesis and maintenance Assembly of the primary cilium Intraflagellar transport
Drugs
Diseases
GWAS		Immune reponse to smallpox (secreted IL-10) ( 22610502) Obesity-related traits ( 23251661)
Protein-Protein Interactions		31 interactors: ANXA7 BICD1 C2orf44 CADM4 CDKN1A DNM2 DYNLL1 DYNLL2 DYNLRB1 DYNLT1 DYNLT3 EMILIN1 FAM110A FAM83D FBP1 GRB7 GSK3B KAT7 MCC NAGK NUDT21 PIN1 RAP1GAP RCC1 RUNDC3B SMN1 STAU1 TAOK1 TK1 TRIM58 UBC	6 interactors: CPEB1 DYNC1I1 DYNC1I2 HSPH1 MPHOSPH6 MPP6
Entrez ID		1780	83658
HPRD ID		04798	06203
Ensembl ID		ENSG00000158560	ENSG00000125971
Uniprot IDs		A4D1I7 B4DME3 F5H050 G5E9K1 O14576 Q8N542 Q8TBF7	B4DFR2 Q9NP97
PDB IDs			1Z09 2B95 2E8J 2HZ5
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Mitotic Cell Cycle Cell Cycle Process Cell Cycle Mitotic Cell Cycle Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Signal Transduction Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Signaling Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Mitochondrion Organization Apoptotic Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of Programmed Cell Death Intracellular MRNA Localization Positive Regulation Of Cell Death Regulation Of Organelle Organization Regulation Of Ras Protein Signal Transduction Regulation Of Mitotic Cell Cycle Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Stress Granule Assembly Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Regulation Of Mitochondrion Organization Regulation Of Small GTPase Mediated Signal Transduction Microtubule-based Process Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Protein Tetramerization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Antigen Processing And Presentation Regulation Of Ras GTPase Activity Viral Process Mitotic Nuclear Division Intracellular Transport Of Virus Response To Metal Ion Positive Regulation Of Apoptotic Process Regulation Of Cell Growth Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Intracellular Signal Transduction DNA Damage Checkpoint Apoptotic Process G1/S Transition Of Mitotic Cell Cycle Fibroblast Growth Factor Receptor Signaling Pathway Programmed Cell Death Ribonucleoprotein Complex Assembly Negative Regulation Of Phosphorylation	Maturation Of 5.8S RRNA Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II RRNA Processing RRNA Metabolic Process Ribosome Biogenesis Positive Regulation Of NK T Cell Activation Positive Regulation Of MHC Class I Biosynthetic Process Negative Regulation Of Cytoplasmic Translation Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Microtubule-based Movement Regulation Of Cytoplasmic Translation Ribonucleoprotein Complex Biogenesis Regulation Of MHC Class I Biosynthetic Process Synaptonemal Complex Assembly NcRNA Metabolic Process Synaptonemal Complex Organization Chaperone Mediated Protein Folding Requiring Cofactor
Tagcloud ?		10q24 17p13 cgh cnvs congenital deletions dlx5 duplications eexons encompassing enhancer enhancers exonic exons families foot fourth hearing hs1642 kb malformation microdeletions shfm shfm1 split syndromic telomeric tp63 unrelated	associates bicd2 bona chains cilia ciliopathies ciliopathy define dynactin dynein dynll2 dynlt3 encoded fide ift intraflagellar lc8 lis1 nudcd3 pafah1b1 retrograde roadblock tctex tctex1d2 wdr34 wdr60
Tagcloud (Difference) ?		10q24 17p13 cgh cnvs congenital deletions dlx5 duplications eexons encompassing enhancer enhancers exonic exons families foot fourth hearing hs1642 kb malformation microdeletions shfm shfm1 split syndromic telomeric tp63 unrelated	associates bicd2 bona chains cilia ciliopathies ciliopathy define dynactin dynein dynll2 dynlt3 encoded fide ift intraflagellar lc8 lis1 nudcd3 pafah1b1 retrograde roadblock tctex tctex1d2 wdr34 wdr60
Tagcloud (Intersection) ?