VAPA and OSBP

Number of citations of the paper that reports this interaction (PMID 12023275)
54

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		VAPA	OSBP
Gene Name		VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa	oxysterol binding protein
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Tight Junction Microtubule Cytoskeleton Integral Component Of Membrane Vesicle Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Exit Site	Golgi Membrane Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cell Junction
	Molecular Function	Signal Transducer Activity Protein Binding Microtubule Binding Protein Domain Specific Binding FFAT Motif Binding Protein Heterodimerization Activity	Protein Binding Oxysterol Binding Protein Domain Specific Binding
	Biological Process	Sphingolipid Metabolic Process ER To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Signal Transduction Cell Death Sphingolipid Biosynthetic Process Neuron Projection Development Protein Folding In Endoplasmic Reticulum Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Small Molecule Metabolic Process Positive Regulation By Host Of Viral Release From Host Cell Negative Regulation By Host Of Viral Genome Replication Positive Regulation By Host Of Viral Genome Replication Membrane Fusion Protein Localization To Endoplasmic Reticulum COPII-coated Vesicle Budding	Lipid Transport
Pathways		Sphingolipid metabolism Metabolism of lipids and lipoproteins Sphingolipid de novo biosynthesis	Sphingolipid metabolism Metabolism of lipids and lipoproteins Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Pulmonary function (interaction) ( 23284291)
Protein-Protein Interactions		15 interactors: ADRB2 APOD APP CACNG1 EGFR GPR128 NSF OPRM1 OSBP RMDN3 SIK1 VAMP1 VAMP2 VAPB ZBTB22	2 interactors: CSNK2A1 VAPA
Entrez ID		9218	5007
HPRD ID		09299	01327
Ensembl ID		ENSG00000101558	ENSG00000110048
Uniprot IDs		Q9P0L0	P22059
PDB IDs		2RR3	2RR3
Enriched GO Terms of Interacting Partners?		Metal Ion Homeostasis Ion Homeostasis Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Cellular Localization Exocytosis Membrane Fusion Cellular Metal Ion Homeostasis Golgi To Plasma Membrane Protein Transport Establishment Of Localization In Cell Homeostatic Process Membrane Organization Cellular Cation Homeostasis Chemical Homeostasis Cellular Ion Homeostasis Vesicle-mediated Transport Transport Intracellular Transport Golgi To Plasma Membrane Transport Secretion By Cell Cellular Chemical Homeostasis Vesicle Organization Regulation Of Cellular Localization Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Vasodilation Establishment Of Protein Localization To Membrane Vesicle Fusion Regulation Of Ion Transport Regulation Of Protein Transport Secretion Regulation Of Intracellular Protein Transport Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Golgi Vesicle Transport Regulation Of Adenylate Cyclase Activity Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Establishment Of Protein Localization Negative Regulation Of Wnt Protein Secretion Alkanesulfonate Metabolic Process Negative Regulation Of T Cell Migration Negative Regulation Of Lipoprotein Lipid Oxidation Negative Regulation By Host Of Viral Release From Host Cell Cytoplasmic Transport Cellular Homeostasis Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Cyclase Activity Regulation Of Sodium Ion Transport Regulation Of Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway	Negative Regulation By Host Of Viral Genome Replication Positive Regulation By Host Of Viral Release From Host Cell Positive Regulation By Host Of Viral Genome Replication Positive Regulation By Host Of Viral Process Positive Regulation Of Viral Release From Host Cell Neuron Projection Development Neuron Development Positive Regulation Of Viral Genome Replication COPII-coated Vesicle Budding Regulation Of Viral Release From Host Cell Cell Death Death Neuron Differentiation Cell Projection Organization Interaction With Symbiont Positive Regulation Of Signal Transduction Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Localization Within Membrane Negative Regulation Of Viral Genome Replication Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition Generation Of Neurons Neurogenesis Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Chaperone-mediated Protein Folding Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Viral Genome Replication Cell Development Positive Regulation Of Viral Process Negative Regulation Of Viral Process Negative Regulation Of Cellular Protein Catabolic Process Sphingolipid Biosynthetic Process Membrane Budding Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Chromosome Organization ER To Golgi Vesicle-mediated Transport Nervous System Development Negative Regulation Of Protein Catabolic Process Positive Regulation Of Cell Growth Regulation Of Mitotic Nuclear Division Protein Localization To Endoplasmic Reticulum Membrane Fusion Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition
Tagcloud ?		abolished acetate acidic akts473 beta1 canonical consistently disruption ffat homolog homology hyperphosphorylated integrin interacting mechanistic motif myristate orp3 oxysterol phenylalanines phorbol pleckstrin pm pma ras requirements selectively stimulate subcellular	apoptosis coincided cytoplasmic explanation fas fasl hcc hepatoma hepg2 induces jurkat markedly mechanistic membrane mir offer orp8 overexpression plasma poorly provided putative relocation strongly translocation triggered underlying understood xenograft
Tagcloud (Difference) ?		abolished acetate acidic akts473 beta1 canonical consistently disruption ffat homolog homology hyperphosphorylated integrin interacting motif myristate orp3 oxysterol phenylalanines phorbol pleckstrin pm pma ras requirements selectively stimulate subcellular	apoptosis coincided cytoplasmic explanation fas fasl hcc hepatoma hepg2 induces jurkat markedly membrane mir offer orp8 overexpression plasma poorly provided putative relocation strongly translocation triggered underlying understood xenograft
Tagcloud (Intersection) ?		mechanistic