VAPA and RMDN3

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		VAPA	RMDN3
Gene Name		VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa	regulator of microtubule dynamics 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Tight Junction Microtubule Cytoskeleton Integral Component Of Membrane Vesicle Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Exit Site	Spindle Pole Nucleus Mitochondrion Mitochondrial Outer Membrane Microtubule Integral Component Of Membrane
	Molecular Function	Signal Transducer Activity Protein Binding Microtubule Binding Protein Domain Specific Binding FFAT Motif Binding Protein Heterodimerization Activity	Protein Binding
	Biological Process	Sphingolipid Metabolic Process ER To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Signal Transduction Cell Death Sphingolipid Biosynthetic Process Neuron Projection Development Protein Folding In Endoplasmic Reticulum Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Small Molecule Metabolic Process Positive Regulation By Host Of Viral Release From Host Cell Negative Regulation By Host Of Viral Genome Replication Positive Regulation By Host Of Viral Genome Replication Membrane Fusion Protein Localization To Endoplasmic Reticulum COPII-coated Vesicle Budding	Cellular Calcium Ion Homeostasis Apoptotic Process Cell Differentiation
Pathways		Sphingolipid metabolism Metabolism of lipids and lipoproteins Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Pulmonary function (interaction) ( 23284291)
Protein-Protein Interactions		15 interactors: ADRB2 APOD APP CACNG1 EGFR GPR128 NSF OPRM1 OSBP RMDN3 SIK1 VAMP1 VAMP2 VAPB ZBTB22	6 interactors: EGFL8 PSEN1 VAPA YWHAB YWHAG YWHAZ
Entrez ID		9218	55177
HPRD ID		09299	07687
Ensembl ID		ENSG00000101558	ENSG00000137824
Uniprot IDs		Q9P0L0	Q96TC7
PDB IDs		2RR3
Enriched GO Terms of Interacting Partners?		Metal Ion Homeostasis Ion Homeostasis Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Cellular Localization Exocytosis Membrane Fusion Cellular Metal Ion Homeostasis Golgi To Plasma Membrane Protein Transport Establishment Of Localization In Cell Homeostatic Process Membrane Organization Cellular Cation Homeostasis Chemical Homeostasis Cellular Ion Homeostasis Vesicle-mediated Transport Transport Intracellular Transport Golgi To Plasma Membrane Transport Secretion By Cell Cellular Chemical Homeostasis Vesicle Organization Regulation Of Cellular Localization Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Vasodilation Establishment Of Protein Localization To Membrane Vesicle Fusion Regulation Of Ion Transport Regulation Of Protein Transport Secretion Regulation Of Intracellular Protein Transport Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Golgi Vesicle Transport Regulation Of Adenylate Cyclase Activity Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Establishment Of Protein Localization Negative Regulation Of Wnt Protein Secretion Alkanesulfonate Metabolic Process Negative Regulation Of T Cell Migration Negative Regulation Of Lipoprotein Lipid Oxidation Negative Regulation By Host Of Viral Release From Host Cell Cytoplasmic Transport Cellular Homeostasis Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Cyclase Activity Regulation Of Sodium Ion Transport Regulation Of Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway	Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Cell Death Death Positive Regulation Of Signal Transduction Regulation Of Mitochondrion Organization Intracellular Transport Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Protein Localization Establishment Of Localization In Cell Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Membrane Organization Positive Regulation Of Intracellular Transport Cellular Localization Apoptotic Process Programmed Cell Death Regulation Of Signal Transduction Apoptotic Signaling Pathway Regulation Of Signaling Positive Regulation Of Organelle Organization Cellular Protein Localization Protein Targeting Protein Transport Regulation Of Intracellular Transport Ammonium Transport Activation Of MAPKK Activity Regulation Of Apoptotic Process Establishment Of Protein Localization Regulation Of Cell Death Generation Of Neurons Neurogenesis Intracellular Signal Transduction Cajal-Retzius Cell Differentiation Beta-amyloid Formation Regulation Of Cellular Component Organization Regulation Of Establishment Of Protein Localization Regulation Of Protein Kinase Activity Positive Regulation Of Transport Regulation Of Kinase Activity Regulation Of Protein Localization Mitochondrial Transport Positive Regulation Of Intracellular Signal Transduction Leukocyte Activation Involved In Immune Response Negative Regulation Of Cellular Protein Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Tagcloud ?		abolished acetate acidic akts473 beta1 canonical consistently disruption ffat homolog homology hyperphosphorylated integrin interacting mechanistic motif myristate orp3 oxysterol phenylalanines phorbol pleckstrin pm pma ras requirements selectively stimulate subcellular
Tagcloud (Difference) ?		abolished acetate acidic akts473 beta1 canonical consistently disruption ffat homolog homology hyperphosphorylated integrin interacting mechanistic motif myristate orp3 oxysterol phenylalanines phorbol pleckstrin pm pma ras requirements selectively stimulate subcellular
Tagcloud (Intersection) ?