VAPA and VAMP1

Number of citations of the paper that reports this interaction (PMID 9657962)
22

Data Source:
HPRD (in vitro)

		VAPA	VAMP1
Gene Name		VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa	vesicle-associated membrane protein 1 (synaptobrevin 1)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Tight Junction Microtubule Cytoskeleton Integral Component Of Membrane Vesicle Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Exit Site	Mitochondrial Outer Membrane Cytosol Integral Component Of Plasma Membrane Synaptic Vesicle Cell Surface Cell Junction Synaptic Vesicle Membrane SNARE Complex Azurophil Granule Membrane Specific Granule Membrane Neuron Projection Tertiary Granule Membrane
	Molecular Function	Signal Transducer Activity Protein Binding Microtubule Binding Protein Domain Specific Binding FFAT Motif Binding Protein Heterodimerization Activity	SNARE Binding SNAP Receptor Activity Protein Binding
	Biological Process	Sphingolipid Metabolic Process ER To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Signal Transduction Cell Death Sphingolipid Biosynthetic Process Neuron Projection Development Protein Folding In Endoplasmic Reticulum Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Small Molecule Metabolic Process Positive Regulation By Host Of Viral Release From Host Cell Negative Regulation By Host Of Viral Genome Replication Positive Regulation By Host Of Viral Genome Replication Membrane Fusion Protein Localization To Endoplasmic Reticulum COPII-coated Vesicle Budding	Exocytosis Vesicle Fusion Pathogenesis SNARE Complex Assembly
Pathways		Sphingolipid metabolism Metabolism of lipids and lipoproteins Sphingolipid de novo biosynthesis	Toxicity of botulinum toxin type G (BoNT/G) Uptake and actions of bacterial toxins Toxicity of botulinum toxin type D (BoNT/D) Toxicity of botulinum toxin type F (BoNT/F) Neurotoxicity of clostridium toxins
Drugs
Diseases
GWAS		Pulmonary function (interaction) ( 23284291)	Hip geometry ( 17903296)
Protein-Protein Interactions		15 interactors: ADRB2 APOD APP CACNG1 EGFR GPR128 NSF OPRM1 OSBP RMDN3 SIK1 VAMP1 VAMP2 VAPB ZBTB22	9 interactors: BCAP31 CCDC155 SNAP23 SNAP29 STX1A STX1B STX4 VAPA VAPB
Entrez ID		9218	6843
HPRD ID		09299	01716
Ensembl ID		ENSG00000101558	ENSG00000139190
Uniprot IDs		Q9P0L0	P23763
PDB IDs		2RR3
Enriched GO Terms of Interacting Partners?		Metal Ion Homeostasis Ion Homeostasis Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Cellular Localization Exocytosis Membrane Fusion Cellular Metal Ion Homeostasis Golgi To Plasma Membrane Protein Transport Establishment Of Localization In Cell Homeostatic Process Membrane Organization Cellular Cation Homeostasis Chemical Homeostasis Cellular Ion Homeostasis Vesicle-mediated Transport Transport Intracellular Transport Golgi To Plasma Membrane Transport Secretion By Cell Cellular Chemical Homeostasis Vesicle Organization Regulation Of Cellular Localization Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Vasodilation Establishment Of Protein Localization To Membrane Vesicle Fusion Regulation Of Ion Transport Regulation Of Protein Transport Secretion Regulation Of Intracellular Protein Transport Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Golgi Vesicle Transport Regulation Of Adenylate Cyclase Activity Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Establishment Of Protein Localization Negative Regulation Of Wnt Protein Secretion Alkanesulfonate Metabolic Process Negative Regulation Of T Cell Migration Negative Regulation Of Lipoprotein Lipid Oxidation Negative Regulation By Host Of Viral Release From Host Cell Cytoplasmic Transport Cellular Homeostasis Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Cyclase Activity Regulation Of Sodium Ion Transport Regulation Of Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway	Synaptic Vesicle Fusion To Presynaptic Membrane Vesicle Organization Membrane Fusion Vesicle Fusion Synaptic Vesicle Exocytosis Organelle Fusion Neurotransmitter Secretion Synaptic Vesicle Transport Establishment Of Localization In Cell Establishment Of Organelle Localization Regulation Of Neurotransmitter Levels Cellular Localization Vesicle-mediated Transport Neurotransmitter Transport Organelle Localization Membrane Organization Establishment Of Vesicle Localization Vesicle Localization Golgi Vesicle Transport Exocytosis Negative Regulation By Host Of Viral Genome Replication Positive Regulation By Host Of Viral Release From Host Cell Intracellular Transport Secretion By Cell Protein Localization Organelle Organization Synaptic Transmission Positive Regulation By Host Of Viral Genome Replication Positive Regulation By Host Of Viral Process Secretion Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Docking Positive Regulation Of Viral Release From Host Cell Protein Transport Vesicle Docking Establishment Of Protein Localization Membrane Docking Synaptic Vesicle Priming ER To Golgi Vesicle-mediated Transport Positive Regulation Of Synaptic Transmission Cell-cell Signaling Positive Regulation Of Neurotransmitter Secretion Regulation Of Exocytosis Transport Positive Regulation Of Viral Genome Replication COPII-coated Vesicle Budding Regulation Of Viral Release From Host Cell Cellular Protein Localization Interaction With Symbiont Regulation Of Synaptic Vesicle Exocytosis
Tagcloud ?		abolished acetate acidic akts473 beta1 canonical consistently disruption ffat homolog homology hyperphosphorylated integrin interacting mechanistic motif myristate orp3 oxysterol phenylalanines phorbol pleckstrin pm pma ras requirements selectively stimulate subcellular	adipocytes biol cellubrevin conjugate diaminobenzidine encompassing ethylmaleimide fill glut1 glut4 gould gst guanosine horseradish itinerant james livingstone localizes martin permeabilized postendocytic slot snares streptolysin tails tellam thio triphosphate vamp2
Tagcloud (Difference) ?		abolished acetate acidic akts473 beta1 canonical consistently disruption ffat homolog homology hyperphosphorylated integrin interacting mechanistic motif myristate orp3 oxysterol phenylalanines phorbol pleckstrin pm pma ras requirements selectively stimulate subcellular	adipocytes biol cellubrevin conjugate diaminobenzidine encompassing ethylmaleimide fill glut1 glut4 gould gst guanosine horseradish itinerant james livingstone localizes martin permeabilized postendocytic slot snares streptolysin tails tellam thio triphosphate vamp2
Tagcloud (Intersection) ?